Central pathways mediating autonomic cardiovascular adjustments to fear

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15190
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: Tottori University
• Principal Investigator: Koba Satoshi 鳥取大学, 医学部, 准教授 (40565743)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 恐怖 / 徐脈 / 自律神経

Outline of Final Research Achievements

This project aimed to identify central circuitries underlying fear bradycardia. The neural tracing experiments combined with immunofluorescence found several central cardiovascular multisynaptic pathways throughout the rat whole brain. In vivo observations of cardiovascular parameters during fear in rats combined with optogenetics or DREADDs were further conducted to determine functional roles a cardiovascular pathway identified by neural tracing experiments plays in fear bradycardia. Selective inhibition of neuronal excitation by the cardiovascular pathway did not affect fear bradycardia in conscious rats.

Free Research Field

自律神経生理学