Strategy for regulating the gut microbiota for nutritional approach of next generation

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15191
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Environmental physiology(including physical medicine and nutritional physiology)
• Research Institution: The University of Tokushima
• Principal Investigator: UEBANSO Takashi 徳島大学, 大学院医歯薬学研究部(医学系), 特任助教 (10581829)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 栄養学

Outline of Final Research Achievements

In this study, we focused on vitamins among the nutrients whose deficiency is pointed out in Japanese national health nutrition survey etc., and comprehensively analyzed metabolites concentration on B-vitamins (B2, B6, B9, B12) deficient diet fed mice. We found a metabolite whose concentration rises when vitamin deficiency occurs. Since this metabolite is not produced in a state where the intestinal bacterial flora is destroyed, it is considered that at least a part of it is synthesized by intestinal bacteria. In addition, abnormal responsiveness to nutrient deficiency was observed in mice that broke the intestinal bacterial flora.　Based on these findings, analyzing metabolic substances of meal components by intestinal bacterial flora likely to not only estimate the dietary ingredients intake, but it is lead to the development of a method of evaluating the host's intestinal environment.

Free Research Field

栄養学