2017 Fiscal Year Final Research Report
Elucidation of pathology caused by heterolysis and development of its visualization method using MRI
| Project/Area Number |
16K15231
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| Research Category |
Grant-in-Aid for Challenging Exploratory Research
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kanazawa University |
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Principal Investigator |
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| Research Collaborator |
MIYATAKE Yuji 大阪大学, 医学系, 大学院生
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 他者融解 / リソソーム |
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| Outline of Final Research Achievements |
Secretion of lysosomal enzymes from macrophages or neutrophils is called heterolysis, but what kind of physiological phenomena or pathological condition can be induced by heterolysis remains elusive. We recently identified a candidate molecule that regulates this process and confirmed that this molecule actually promotes heterolysis. When cardiovascular inflammation was induced in mice deficient in this molecule, the onset of cardiovascular inflammation was reduced as compared with the wild type mice. Furthermore, in order to clarify what type of lysosomal enzyme is actually released to cause organ and tissue damage in vivo by using MRI, we developed a new smart probe using 19F nanoparticles and a gadolinium complex.
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| Free Research Field |
免疫学
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