2018 Fiscal Year Final Research Report
Deciphering aging mechanism
Project/Area Number |
16K15415
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Research Category |
Grant-in-Aid for Challenging Exploratory Research
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Allocation Type | Multi-year Fund |
Research Field |
General internal medicine(including psychosomatic medicine)
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Research Institution | Keio University |
Principal Investigator |
Yuasa Shinsuke 慶應義塾大学, 医学部(信濃町), 講師 (90398628)
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Project Period (FY) |
2016-04-01 – 2019-03-31
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Keywords | 老化 / 細胞 |
Outline of Final Research Achievements |
Aging is the basis of various human diseases. In order to develop the medical approach to control aging, it is necessary to understand the molecular basis of aging. Aging research is conducted by cellular model in vitro, short-lived experimental organisms such as nematodes, genetically modified mice, long-term intervention studies using large animals such as monkeys, genetic analysis studies on hereditary aging syndrome, and iPS cells derived from patients with aging syndrome. All experimental models have strengths and weaknesses, and have been studied complementarily. In this study, we used a variety of models to search for aging mechanisms.
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Free Research Field |
循環器内科
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Academic Significance and Societal Importance of the Research Achievements |
本研究により、老化の進展に関わる分子を特定している。同分子に介入することにより、老化モデルにおける老化の制御に成功している。今後は、さらなる老化モデルでの検証を行い、詳細な分子機序の探索を継続する。将来は、老化を制御する薬剤の開発へ役立つ可能性がある。
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