Search for factors inducing radioresistance using lentivirus libraries

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15577
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Radiation science
• Research Institution: Kyoto University
• Principal Investigator: Kobayashi Minoru 京都大学, 放射線生物研究センター, 特定研究員 (40644894)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 放射線抵抗性 / 遺伝子スクリーニング

Outline of Final Research Achievements

Overcoming the radioresistance of cancer is an important issue. However, regulatory factor for radiosensitivity of cells are still unclear. That is a major problem in radiation therapy. Therefore, we screened the genes involved in the regulation of radiation resistance of cancer cells and analyzed their mechanisms.
One of candidate genes induce radioresistance by the increase in antioxidant property through changing intracellular redox status. Cancer cells acquire antioxidant phenotypes through metabolic reprogramming including acceleration of pentose-phosphate pathway in a HIF-1 dependent manner. We expected that inhibitors targeting this gene will be used to overcome the radioresistance of cancer.

Free Research Field

放射線腫瘍学