Common marmoset as a primate model for gerontology in dentistry

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K15852
• Research Category: Grant-in-Aid for Challenging Exploratory Research
• Allocation Type: Multi-year Fund
• Research Field: Social dentistry
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: KUMEI Yasuhiro 東京医科歯科大学, 大学院医歯学総合研究科, 講師 (30161714)
• Co-Investigator(Kenkyū-buntansha): 水口 俊介 東京医科歯科大学, 大学院医歯学総合研究科, 教授 (30219688) ; 馬場 麻人 徳島大学, 大学院医歯薬学研究部(歯学系), 教授 (90251545)
• Research Collaborator: MINAKUCHI Shunsuke 東京医科歯科大学, 大学院医歯学総合研究科, 教授 ; TAKEHARA Sachiko 東京女子医科大学, 医学部衛生学, 特任助教 ; ZEREDO Jorge 国立ブラジリア大学, 健康科学部, 教授
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 霊長類モデル / コモンマーモセット / 口腔細菌 / X線動画診断 / 加齢 / 咀嚼嚥下 / 呼吸機能 / メタゲノム解析

Outline of Final Research Achievements

In the common marmoset, the problems associated with aging such as jaw and cranium, periodontal tissue, jaw movement, chewing / swallowing, respiratory function, etc. were clarified. Then, the utility of common marmoset as a human elderly model was evaluated. Three-dimensional X-ray motion pictures (cineradiograph) were taken with the elderly common marmosets in unconstrained state, and comparative analyzes of functions such as jaw movement, chewing / swallowing, respiration were conducted with reference to juvenile controls. In results, anatomical and functional changes was confirmed, and metagenome analysis of oral bacterial flora, bacteria common to humans and marmosets and the species-specific bacteria were clarified. Changes in the oral flora with aging were also observed. Common marmoset was confirmed to be highly useful as an oral disease model of human elderly.

Free Research Field

硬組織病態生化学