2017 Fiscal Year Final Research Report
Identification of genes associated with resistance to chronic kidney disease
| Project/Area Number |
16K16606
|
|---|
| Research Category |
Grant-in-Aid for Young Scientists (B)
|
| Allocation Type | Multi-year Fund |
|---|
| Research Field |
Applied health science
|
|---|
| Research Institution | Kitasato University |
|---|
Principal Investigator |
|
|---|
| Research Collaborator |
Takahashi YUKI
Okawara SHIORI
|
|---|
| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 慢性腎臓病 / ポドサイト傷害 / 糸球体傷害 / 尿細管間質傷害 |
|---|
| Outline of Final Research Achievements |
Increasing numbers of patients with chronic kidney disease has emerged as a social problem. Using mouse genetic method, I have identified two genetic loci resistant to podocyte injury and tubulointerstitial injury, respectively. In this study, a genome-wide linkage analysis of backcrosses between susceptible FVB/NJ- and resistant C57BL/6J-derived mouse strains to podocyte injury detected a novel major modifier locus on chromosome 10. To identify candidate genes for these genetic loci, I performed exome and transcriptome analyses comparing susceptible and resistant mouse strains. The identification of these responsible genes could lead to the development of new treatment strategies for chronic kidney disease.
|
| Free Research Field |
実験動物学
|
