2017 Fiscal Year Final Research Report
Efficient synthesis of nitrogen-containing compounds with yanamides
| Project/Area Number |
16K18842
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | イナミド / 酸 / 中員環合成 / 生物活性物質 / インドリン |
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| Outline of Final Research Achievements |
We have developed an efficient cyclization reaction with the formation of keteneiminium as a key intermediate by acid to ynamide. Succeeded in constructing a spiroindoline skeleton at once by a continuous cyclization reaction using an ynamide containing enamide with an external nucleophile. In addition, it was possible to synthesize medium heterocyclic ring, which is generally difficult to synthesize, by using ynamide.
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| Free Research Field |
有機化学
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