2017 Fiscal Year Final Research Report
Development of domino doublespiro cyclization
| Project/Area Number |
16K18853
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Chemical pharmacy
|
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| Research Institution | Hoshi University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | ドミノ反応 / スピロ環化 / 薬剤耐性克服効果 / ジアステレオ選択的 / 全合成 |
|---|
| Outline of Final Research Achievements |
We have developed a method for the synthesis of doublespirocycles in high yield and high diastereoselective manner. In addition, we have also established a simple and rapid method for the synthesis of the cyclization precursor. The reaction we developed here was applied to the synthetic study on the grandilodine C with drug-resistant reversing effect.
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| Free Research Field |
有機化学
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