2017 Fiscal Year Final Research Report
Pharmacokinetic analysis for TDM of anti-HIV drug dolutegravir.
| Project/Area Number |
16K18938
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Medical pharmacy
|
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| Research Institution | Kyoto University |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | 抗HIV薬 / TDM / 薬物動態 / 個別化医療 / エイズ / LC/MS/MS / アドヒアランス / トランスポータ |
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| Outline of Final Research Achievements |
In current study, we tried to identify pharmacokinetic regulatory factors of the integrase inhibitor dolutegravir with the aim of accumulating basic information for Therapeutic Drug Monitoring (TDM) of anti-HIV drugs. As a result, it became clear that dolutegravir will serve as a substrate for BCRP, an efflux transporter. It was suggested that BCRP is involved as one of pharmacokinetic regulators of dolutegravir, and obtained a useful finding for the development to clinical studies using the human blood sample in the future.
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| Free Research Field |
医療薬剤学
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