2017 Fiscal Year Final Research Report
Functional analysis of BIG3 on triple-negative breast cancer progression
| Project/Area Number |
16K19052
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Pathological medical chemistry
|
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| Research Institution | Kindai University (2017)
The University of Tokushima (2016) |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 乳癌 / ゲノム / シグナル伝達 / プロテオーム / 発現制御 |
|---|
| Outline of Final Research Achievements |
We identified novel BIG3-interacting factors including microtubule-regulated molecule in ER-negative breast cancer. We further analyzed BIG3-these factors interactions and colocalization by immunoprecipitation and immunostaining. On the other hand, knockdown of BIG3 expression with small-interfering RNA reduced E2F1 expression and cellular growth of ER-negative breast cancer. These results suggest that BIG3 directly regulates cellular survival and growth of ER-negative breast cancer through regulation of microtubule or cell cycle.
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| Free Research Field |
腫瘍学
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