Investigation of serum Vitamin D levels and first immunoglobulin reactivity in Kawasaki disease patients

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K19647
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Pediatrics
• Research Institution: Yamaguchi University
• Principal Investigator: SUZUKI Yasuo 山口大学, 大学院医学系研究科, 講師(特命) (00593302)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 川崎病 / 血清ビタミンD濃度 / ガンマグロブリン治療反応性 / 冠動脈障害 / 血清ビタミンD結合蛋白濃度

Outline of Final Research Achievements

Kawasaki disease is an acute inflammatory illness in early childhood. Coronary artery lesion is a serious complication of kawasaki disease. Vitamin D is a hormone that maintains calcium homeostasis and participates in bone metabolism. Another effect have anti-inflammatory effect. We measured serum 25(OH)D levels at acute phase of KD patients. The number of patients with high Gunma score (≧ 5 points) was significantly higher in the initial IVIG non-responders than the responders. Serum 25(OH)D levels in initial IVIG non-responders was lower than that of initial IVIG responders. Vitamin D might decresed IVIG non-responders.

Free Research Field

小児科

Academic Significance and Societal Importance of the Research Achievements

川崎病発症には, 地域人種差があり世界的にも日本の発症率は高い. 環境因子について検討し川崎病初期治療における反応性にビタミンD濃度が関与している可能性がある. 現代は子供のビタミンD濃度が低いことが多く, ビタミンD補充を行うことで川崎病の治療成績が向上し冠動脈障害発症が低下し医療費削減に貢献する可能性がある.