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2018 Fiscal Year Final Research Report

Research on the pathophysiology of attention deficit based on glial cell line-derived neurotrophic factor

Research Project

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Project/Area Number 16K19750
Research Category

Grant-in-Aid for Young Scientists (B)

Allocation TypeMulti-year Fund
Research Field Psychiatric science
Research InstitutionChiba University

Principal Investigator

Niitsu Tomihisa  千葉大学, 大学院医学研究院, 講師 (90456054)

Research Collaborator Iyo Masaomi  
Hashimoto Kenji  
Hashimoto Tasuku  
Sasaki Tsuyoshi  
Oda Yasunori  
Kimura Atsushi  
Hata Tatsuki  
Idemoto Keita  
Project Period (FY) 2016-04-01 – 2019-03-31
Keywordsグリア細胞株由来神経栄養因子 / 注意欠陥多動性障害 / 気分障害 / うつ病 / 双極性障害
Outline of Final Research Achievements

Serum levels of glial cell line-derived neurotrophic factor (GDNF) were associated with severity of attention deficits in adult patients with attention deficits/hyperactivity disorder (ADHD). Decreased serum levels of GDNF were associated with severity of mood disorders, major depressive disorder and bipolar disorder. Serum levels of GDNF may be a potential biomarker for ADHD and mood disorders.

Free Research Field

精神医学

Academic Significance and Societal Importance of the Research Achievements

注意障害は多くの精神疾患に共通して認められる。そのため、注意障害は精神疾患患者の日常生活や就労に大きな影響を与えており、社会経済的影響も大きい障害といえる。今回の研究成果は、グリア細胞株由来神経栄養因子(GDNF)が注意欠陥多動性障害(ADHD)や気分障害の病態に関連していることを見出した。今後、GDNFに基づいたADHDや気分障害の病態解明および治療法の開発へつながることが期待される。

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Published: 2020-03-30  

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