2017 Fiscal Year Final Research Report
Assessment of Stereotactic Micro beam Radiation Therapy
| Project/Area Number |
16K19818
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Radiation science
|
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| Research Institution | Kobe University |
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Principal Investigator |
|
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| Project Period (FY) |
2016-04-01 – 2018-03-31
|
| Keywords | マイクロビーム / 放射光 / SPring-8 |
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| Outline of Final Research Achievements |
Synchrotron X-ray beams permit the delivery of very high radiation doses to tumors in short period of time with a single fraction using arrays of micro-slit beam radiation therapy. In this study, we have challenged to treat multiple metastatic lung tumors by applying MRT to mouse tumor-bearing right lung with comparing to the broad beam treatment from the same radiation source.
According to microscopic observations, the areas of tumor on the slides were reduced to one-third compared to the unirradiated region in the slides of 120 Gy MRT while the total lung area was not collapsed and maintained its original size.
Such high doses of MRT can diminish the tumor volumes without breaching of lung tissue scaffoldings. There is a good possibility that MRT would control the growth of metastatic lung tumors.
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| Free Research Field |
医学物理学
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