2017 Fiscal Year Final Research Report
The effect of duodenal-jejunal bypass on DM and NASH regarding gut immunosystem via FXR.
| Project/Area Number |
16K19896
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
General surgery
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| Research Institution | The University of Tokushima |
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Principal Investigator |
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | Metabolic surgery / DJ / microbiota / gut inflammtion |
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| Outline of Final Research Achievements |
12 obese and diabetic rats were divided into three groups; DJB (D group, n=4), Sham (S group, n=4) and Liraglutide injection group (L group, n=4). In postoperative 8 weeks, Blood, gut, liver and stool were harvested.
Blood glucose in D and L group were lower than that in S group. D and L group improved insulin resistance. Furthermore, AST and hyaluronic acids in D group were significantly low and D group showed mild score in NASH grading/staging compared with other two groups. D group changed gut microbiota and increased the proportion of Proteobacteria. However, FXR expression in DJB group was not higher than other two group. Therefore, FXR did not affect improvement of DM and NASH in bypass surgery. In addition, D group showed decrease of IFNγ, IL1β and TNFα and strong expression of claudin-1. So, DJB might maintain the gut barrier function.DJB might improve insulin resistance by change of gut microbiota, suppression of gut inflammation and maintenance of gut barrier function.
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| Free Research Field |
医歯薬学
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