Development of new therapeutic agents targeting IL-8/CXCR2 network for esophageal squamous cell carcinoma

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K19954
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Digestive surgery
• Research Institution: Keio University
• Principal Investigator: INOUE MASAZUMI 慶應義塾大学, 医学部(信濃町), 助教 (10627136)
• Research Collaborator: TAKEUCHI Hiroya ; MATSUDA Sachiko
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 食道扁平上皮癌 / ケモカイン / IL-8 / CXCR2

Outline of Final Research Achievements

In this study, we demonstrated that a positive IL-8 and CXCR2 expression correlates significantly with a lower recurrence-free survival rate and overall survival rate in our esophageal squamous cell carcinoma (ESCC) patient population. These results suggest that IL-8/CXCR2 expression in ESCC has a direct impact on the cellular kinetics of ESCC. In vivo, Both internal and external stimulation or inhibition of the IL-8/CXCR2 network resulted in significant enhancement or suppression of cell proliferation in ESCC cell line. In vivo, stimulation or inhibition of the IL-8/CXCR2 network also resulted in enhancement or suppression of ESCC tumor proliferation. Our results demonstrated that stimulation of the IL-8/CXCR2 network clearly enhanced ESCC cell proliferation, while its inhibition obviously suppressed ESCC cell proliferation in vitro. These results indicate that control of IL-8/CXCR2 network signaling may be a new therapeutic strategy for ESCC.

Free Research Field

消化器外科学