Changes in cerebellar network at resting period and investigation of cognitive dysfunction

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20018
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Neurosurgery
• Research Institution: University of the Ryukyus
• Principal Investigator: Shiroma Ayano 琉球大学, 医学(系)研究科(研究院), 非常勤講師 (50751567)
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 安静時脳活動 / 認知機能 / 小脳腫瘍

Outline of Final Research Achievements

Neuropsychological assessments were carried out on 5 patients with benign cerebellar tumors, as well as on a control group consisting of 10 healthy controls. Executive function score before operation was markedly decreased in cerebellar tumor patients compared with healthy controls. As a result of correlation analysis of the BOLD waveform on functional binding between brain regions in resting brain activity, each module of frontal lobe, hippocampus and cerebellar were independent in healthy controls. On the contrary, patients increased cortical association of cerebrum to cerebrum and cerebrum to cerebellum.

Free Research Field

臨床心理学