An analysis of SIRT1 in the pathophysiology of pregnancy associated breast cancer

2017 Fiscal Year Final Research Report

• Project/Area Number: 16K20212
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Obstetrics and gynecology
• Research Institution: Teikyo University
• Principal Investigator: Hiraike Haruko 帝京大学, 公私立大学の部局等, 講師 (30771258)
• Research Collaborator: KANDA Ranka 帝京大学, 産婦人科学講座, 助手
• Project Period (FY): 2016-04-01 – 2018-03-31
• Keywords: 子宮 / 糖代謝 / オートファジー / インクレチン / GLP-1受容体

Outline of Final Research Achievements

The pathophysiological role of glucagon-like peptide-1 receptor (GLP-1R) in endometrial cancer has not been fully elucidated. Here, we investigated the effects of the GLP-1R agonist liraglutide in endometrial cancer cells and examined the association between GLP-1R expression and clinicopathological characteristics in endometrial cancer patients. Liraglutide dose dependently suppressed the cellular growth of Ishikawa endometrial cancer cells and the effect was turned out to be the induction of autophagy and subsequent cell death. Immunohistochemical analysis revealed that GLP-1R expression was associated with positive estrogen and progesterone receptor status, and higher GLP-1R expression was significantly correlated with better progression-free survival. The use of liraglutide to target autophagy in endometrial cancer cells may be a novel potential treatment for endometrial cancer, and higher GLP-1R expression may be associated with better prognosis in endometrial cancer patients.

Free Research Field

産婦人科学