2017 Fiscal Year Final Research Report
Development of novel oligonucleotide therapeutics using functional liposomes for atrophic muscular disorder
| Project/Area Number |
16K20646
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| Research Category |
Grant-in-Aid for Young Scientists (B)
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| Allocation Type | Multi-year Fund |
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| Research Field |
Orthodontics/Pediatric dentistry
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| Research Institution | The University of Tokushima |
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Principal Investigator |
MORI Hiroyo 徳島大学, 病院, 助教 (80733914)
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| Project Period (FY) |
2016-04-01 – 2018-03-31
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| Keywords | 筋萎縮性疾患 / myostatin |
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| Outline of Final Research Achievements |
The present study was designed to assess the effectiveness of the co-delivery of myostatin-targeting siRNA (Mstn-siRNA) and ActRIIB-Fc into skeletal muscle. Inhibition of myostatin function by the combination of Mstn-siRNA and ActRIIB-Fc increased muscle weight and myofibril size in murine masseter muscle. Furthermore, myogenin mRNA expression was upregulated in the combination treatment group, while MuRF-1 and Atrogin-1 mRNA expression was downregulated compared to administration of each compound alone.
These findings suggest that co-administratioin of Mstn-siRNA and ActRIIB-Fc could be a useful treatment of atrophic muscular disease.
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| Free Research Field |
歯科矯正学
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