Establishment of novel bone regeneration therapy utilizing combination of multiple growth factors not susceptible to inflammatory mediator

2018 Fiscal Year Final Research Report

• Project/Area Number: 16K21308
• Research Category: Grant-in-Aid for Young Scientists (B)
• Allocation Type: Multi-year Fund
• Research Field: Dental engineering/Regenerative dentistry; Prosthodontics/ Dental materials science and
• Research Institution: Iwate Medical University
• Principal Investigator: Yokota Jun 岩手医科大学, 歯学部, 助教 (60733730)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: 骨再生法 / サイトカイン / BMP-2 / 炎症性刺激

Outline of Final Research Achievements

Bone morphogenic proteins (BMPs) is reported that the most effective factor for promoting proliferation and differentiation for osteoblast when assuming bone regeneration therapy. However, it has been clarified that BMP is not expected a satisfactory bone formation reaction, because of inflammatory reaction with surgical treatment in vivo.
Therefore, we attempt to establish novel bone regeneration therapy utilizing combination of multiple growth factors which having an acting mechanism different from BMP signal pathway.

Free Research Field

再生医療

Academic Significance and Societal Importance of the Research Achievements

BMP-2は細胞内シグナル系を介して顕著に骨芽細胞へと分化させるが、実際の骨欠損部や外科的侵襲を受けた組織には一時的な炎症反応が起き、様々な炎症性サイトカイン産生が誘導されることで、局所の細胞増殖、分化に関わり、創傷治癒ならびに骨形成に重大な影響を及ぼす。とくにこれらの炎症性刺激はBMP-2に関係するシグナル系の活性化を阻害して骨芽細胞分化ならびに骨形成を抑制することがわかっている。本研究で着目しているBMP以外の複数の成長因子を組み合わせて用いた炎症反応に影響されない骨再生技術確立の試みについては未だ報告がなく、臨床応用可能で画期的な骨再生技術の確立に繋がる可能性が高い。