Serum insulin-like growth factor-1 levels in neurodegenerative diseases

2018 Fiscal Year Annual Research Report

• Project/Area Number: 16K21319
• Research Institution: Dokkyo Medical University
• Principal Investigator: 鈴木 圭輔 獨協医科大学, 医学部, 准教授 (50458379)
• Project Period (FY): 2016-04-01 – 2019-03-31
• Keywords: インスリン様成長因子1 / パーキンソン病関連疾患 / 認知症疾患

Outline of Annual Research Achievements

インスリン様成長因子(IGF-1)は脳の成長，可塑性や生存に関与し，神経変性疾患の病態への関与が示唆されている．我々は様々な神経変性疾患患者156例を対象に血清インスリン様成長因子（IGF-1）値と臨床症候との関連を調査した．
結果，血清IGF-1値はパーキンソン病 (73例) 112.1±5.1 ng/mL，進行性核上性麻痺 (15例) 102.9±8.3 ng/mL，多系統萎縮症 (22例) 103.1±37.6 ng/mL，アルツハイマー病 (18例) 102.2±9.4 ng/mL，筋萎縮性側索硬化症 (6例) 105.5±27.4 ng/mL，レビー小体型認知症 (14例）82.4±7.4 ng/mL, 前頭側頭型認知症 (6例) 90.0±17.0 ng/mL, 大脳皮質基底核変性症 (n=2) 118.0±14.0 ng/mLであり，各疾患の間には血清IGF-1値の有意差はみられなかった．パーキンソン病患者では血清IGF-1値は年齢および日常生活動作の障害（modified Rankin scale）と負の相関を示し，線条体におけるドパミントランスポータースキャンの集積および前頭葉機能（frontal assessment battery score）と正の相関を示した．またアルツハイマー病患者では血清IGF-1値は年齢，罹病期間，modified Rankin scaleと負の相関を示した．
本研究によりパーキンソン病やアルツハイマー病などの神経変性疾患における血清IGF-1値の測定が疾患進行の評価に有用である可能性が示唆された．

Research Products

• [Journal Article] Serum insulin-like growth factor-1 levels in neurodegenerative diseases (2019)
  • Author(s): Suzuki K, Suzuki S, Ishii Y, Fujita H, Matsubara T, Okamura M, Sakuramoto H, Hirata K.
  • Journal Title: Acta Neurol Scand Volume: - Pages: -
  • DOI: 10.1111/ane.13091.
  • Peer Reviewed
• [Journal Article] Restless legs syndrome, leg motor restlessness and their variants in patients with Parkinson's disease and related disorders. (2018)
  • Author(s): Matsubara T, Suzuki K, Fujita H, Watanabe Y, Sakuramoto H, Matsubara M, Hirata K.
  • Journal Title: J Neurol Sci Volume: 393 Pages: 51-57
  • DOI: 10.1016/j.jns.2018.08.007.
  • Peer Reviewed
• [Journal Article] Autonomic Symptoms Correlate with Non-Autonomic Non-Motor Symptoms and Sleep Problems in Patients with Parkinson's Disease. (2018)
  • Author(s): Matsubara T, Suzuki K, Fujita H, Watanabe Y, Sakuramoto H, Matsubara M, Hirata K.
  • Journal Title: Eur Neurol Volume: 80 Pages: 193-199
  • DOI: 10.1159/000495797
  • Peer Reviewed
• [Presentation] Serum insulin-like growth factor-1 levels in patients with dementia disorders (2019)
  • Author(s): Suzuki K, Suzuki S, Ishii Y, Matsubara T, Okamura M, Kadowaki T, Fujita H, Watanabe Y, Sakuramoto H, Hirata K
  • Organizer: AD/PD 2019, Lisbon, Portugal
  • Int'l Joint Research
• [Presentation] Clinical correlation of serum insulin-like growth factor-1 levels in patients with Parkinson’s disease and related disorders. (2018)
  • Author(s): Suzuki K, Kadowaki T, Fujita H, Watanabe Y, Matsubara T, Suzuki S, Ishii Y, Okamura M, Shiina T, Sakuramoto H, Hamaguchi M, Matsubara M, Hirata K
  • Organizer: XXIII World Congress on Parkinson’s Disease and Related Disorders, Lyon, France,
  • Int'l Joint Research
• [Presentation] Serum insulin-like growth factor-1 levels in parkinsonism or dementia disorders. (2018)
  • Author(s): Suzuki K, Suzuki S, Ishii Y, Matsubara T, Fujita H, Watanabe Y, Okamura M, Kadowaki T, Sakuramoto H, Hirata K
  • Organizer: International Congress of Parkinson’s Disease and Movement Disorders, Hong Kong
  • Int'l Joint Research