2009 Fiscal Year Final Research Report
Molecular level clarification of the mechanism for animal skin pattern formation
| Project/Area Number |
17017017
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| Research Category |
Grant-in-Aid for Scientific Research on Priority Areas
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| Allocation Type | Single-year Grants |
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| Review Section |
Biological Sciences
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| Research Institution | Nagoya University |
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Principal Investigator |
KONDO Shigeru Nagoya University, 大学院・生命機能研究科, 教授 (10252503)
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| Co-Investigator(Kenkyū-buntansha) |
WATANABE Masakatsu 大阪大学, 大学院・生命機能研究科, 准教授 (90323807)
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| Project Period (FY) |
2005 – 2009
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| Keywords | ゼブラフィッシュ / 反応拡散 / チューリング / パターン形成 / 色素細胞 |
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| Research Abstract |
We analyzed the mechanism of skin pattern formation in zebrafish in order to have the substantial evidence to prove the hypothesis, "the basic mechanism of biological pattern formation is the Turing wave". We found,(1)the skin pattern of zebrafish has the specific dynamics of Turing wave, (2)the interactions among the pigment cells satisfies the required conditions for the Turing pattern formation, and (3)the key molecules those critical to the wave formation are gap-junction, Notch-Delta and Kir channels. About 90% of the aim of this project is completed. Now our final goal, the detailed identification of the molecular network of Turing wave, should be very close.
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