Promotion and support for a wide range of integrative brain research

2009 Fiscal Year Final Research Report

• Project/Area Number: 17021036
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Tamagawa University
• Principal Investigator: TSUKADA Minoru Tamagawa University, 脳科学研究所, 教授 (80074392)
• Project Period (FY): 2005 – 2009
• Keywords: 遺伝子組み換えラット / マルチユニット・レコーディング / ブレインバンク / プロテオーム解析

Research Abstract

To promote and achieve efficiently and effectively a wide range of integrative brain research, a total of twelve bases has been established for developing and supplying research resources : (1) human brain banks ; (2) transgenic model animals and a test battery for their behavioral analyses ; (3) leading techniques for analyzing brain functions and hard/soft wares for measuring brain dynamics ; (4) leading techniques for analyzing functional brain molecules (for example, proteomics) ; (5) high-quality materials useful for brain research (for example, viral vectors).

Research Products

• [Journal Article] A code for spatial alternation during fixation in rat hippocampal CA1 neurons (2009)
  • Author(s): Takahashi M, Lauwereyns J, Sakurai Y, Tsukada M
  • Journal Title: Journal of Neurophysiology 102 Pages: 556-567
  • Peer Reviewed
• [Journal Article] Mice with altered myelin proteolipid protein gene expression display cognitive deficits accompanied by abnormal neuron-glia interactions and decreased conduction velocities (2009)
  • Author(s): Tanaka H, Isa T, Miyagawa T, et al
  • Journal Title: Journal of Neuroscience 29(26) Pages: 8363-8371
  • Peer Reviewed
• [Journal Article] Identification of functional marker proteins in the mammalian growth cone (2009)
  • Author(s): Nozumi M, Togano T, Takahashi-Niki K, Lu J, Honda A, Taoka M, Shinkawa T, Koga H, Takeuchi K, Isobe T, Igarashi M
  • Journal Title: Proc Natl Acad Sci USA 106(40) Pages: 17210-17215
  • Peer Reviewed
• [Journal Article] Abnormal behavior in a chromosomeengineered mouse model for human 15q11-13 duplication seen in autism (2009)
  • Author(s): Nakatani J, Tamada K, Hatanaka F, Ise S, Ohta H, Inoue K, Tomonaga S, Watanabe Y, Chung YJ, Banerjee R, Iwamoto K, Kato T, Okazawa M, Yamauchi K, Tanda K, Takao K, Miyagawa T, Bradley A, Takumi T
  • Journal Title: Cell 137(7) Pages: 1235-46
  • Peer Reviewed
• [Journal Article] Cannula-aided penetration a simple method to insert structurally weak electrodes into brain through the dura mater (2009)
  • Author(s): Matsuzaka Y, Sakamoto K, Tanaka T, Furusawa Y, Mushiake H
  • Journal Title: Neuroscience Res 65(1) Pages: 126-129
  • Peer Reviewed
• [Journal Article] NMDA receptor GluN2B (GluR epsilon 2/NR2B) subunit is crucial for channel function, postsynaptic macromolecular organization, and actin cytoskeleton at hippocampal CA3 synapses (2009)
  • Author(s): Akashi K, Kakizaki T, Kamiya H, Fukaya M, Yamasaki M, Abe M, Natsume R, Watanabe M, Sakimura K
  • Journal Title: J Neurosci 29 Pages: 10869-82
  • Peer Reviewed
• [Journal Article] Reward prediction based on stimulus categorization in primate lateral prefrontal cortex (2008)
  • Author(s): Pan X, Sawa K, Tsuda I, Tsukada M, Sakagami M
  • Journal Title: Nature Neuroscience 11(6) Pages: 703-712
  • Peer Reviewed
• [Journal Article] Neural correlates of true memory, false memory, and deception (2008)
  • Author(s): Abe N, Okuda J, Suzuki M, Sasaki H, Matsuda T, Mori E, Tsukada M, Fujii T
  • Journal Title: Cerebral Cortex 18 Pages: 2811-2819
  • Peer Reviewed
• [Journal Article] Roles of continuous neurogenesis in the structural and functional integrity of the adult forebrain (2008)
  • Author(s): Imayoshi I, Miyagawa T, et al
  • Journal Title: Nature Neuroscience 11(10) Pages: 1153-61
  • Peer Reviewed
• [Journal Article] Lewy body pathology involves cutaneous nerves (2008)
  • Author(s): Ikemura M, Saito Y, Sengoku R, Sakiyama Y, Hatsuta H, Kanemaru K, Sawabe M, Arai T, Ito G, Iwatsubo T, Fukayama M, Murayama S
  • Journal Title: J Neuropath Exp Neurol 67 Pages: 945-953
  • Peer Reviewed
• [Journal Article] Phosphorylated TDP-43 in frontotemporal lobar degeneration and amyotrophic lateral sclerosis (2008)
  • Author(s): Hasegawa M, Arai T, Nonaka T, Kametani F, Yoshida M, Hashizume Y, Beach T.G., Buratti E, Baralle F, Morita M, Nakano I, Oda T, Tsuchiya K, Akiyama, H
  • Journal Title: Ann. Neurol 64(1) Pages: 60-70
  • Peer Reviewed
• [Journal Article] The relation between spike-timing dependent plasticity and Ca2+ dynamics in the hippocampal CA1 network (2007)
  • Author(s): Aihara T, Abiru Y, Yamazaki Y, Watanabe H, Fukushima Y, Tsukada M
  • Journal Title: Neuroscience 145 Pages: 80-87
  • Peer Reviewed
• [Journal Article] Interaction between the Spatio-Temporal Learning Rule (STLR) and Hebb type (HEBB) in single pyramidal cells in the hippocampal CA1 Area (2007)
  • Author(s): Tsukada M, Yamazaki Y, Kojima H
  • Journal Title: Cognitive Neurodyn 1(2) Pages: 157-167
  • Peer Reviewed
• [Journal Article] Regulation of long-term depression and climbing fiber territory by glutamate receptorδ2 at parallel fiber synapses through its C-terminal domain in cerebellar Purkinje cells (2007)
  • Author(s): Uemura T, Kakizawa S, Yamasaki M, Sakimura K, Watanabe M, Iino M, Mishina M
  • Journal Title: J. Neurosci 27 Pages: 12096-12108
  • Peer Reviewed
• [Journal Article] Glia Nax channels control lactate signaling to neurons for brain [Na+] sensing (2007)
  • Author(s): Shimizu H, Watanabe E, Hiyama T. Y, Nagakura A, Fujisawa A, Okado H, Yanagawa Y, Noda M
  • Journal Title: Neuron 54(1) Pages: 59-72
  • Peer Reviewed
• [Journal Article] Conditional gene targeting on the pure C57BL/6 genetic background (2007)
  • Author(s): Mishina M, Sakimura K
  • Journal Title: Neuroscience Res 58 Pages: 105-112
  • Peer Reviewed
• [Journal Article] Controlled cell targeting system to study the brain neural circuitry (2007)
  • Author(s): Kobayashi K
  • Journal Title: Neuroscience Res 58 Pages: 118-123
  • Peer Reviewed
• [Journal Article] Ca2+-permeable AMAP receptors regulate growth of human glioblastoma via Akt activation (2007)
  • Author(s): Ishiuchi S, Yoshida Y, Sugawara K, Aihara M, Ohtani T, Watanaba T, Saito N, Tsuzuki K, Okado H, Miwa A, Nakazata Y, Ozawa S
  • Journal Title: J. Neurosci 25(30) Pages: 7987-8001
  • Peer Reviewed
• [Journal Article] a component of presynaptic scaffold and Lewy bodies, is required for the suppression of alpha-synuclein neurotoxicity (2007)
  • Author(s): Ihara M, et al
  • Journal Title: Neuron 53(4) Pages: 519-533
  • Peer Reviewed
• [Journal Article] Phase shift of subthreshold theta oscillation in hippocampal CA1 pyramidal cell membrane by excitatory synaptic inputs (2006)
  • Author(s): Watanabe H, Aihara T, Tsukada M
  • Journal Title: Neuroscience 140(4) Pages: 1189-1199
  • Peer Reviewed
• [Journal Article] Multiple candidate gene analysis identifies a-synuclein as a susceptibility gene for sporadic Parkinson's disease (2006)
  • Author(s): Mizuta I, Satake W, Nakabayashi Y, Ito C, Suzuki S, Momose Y, Nagai Y, Oka A, Inoko H, Fukae J, Saito Y, Sawabe M, Murayama S, Yamamoto M, Hattori N, Murata M, Toda T
  • Journal Title: Hum Mol Gen 15 Pages: 1151-1158
  • Peer Reviewed
• [Journal Article] Spatial analisis of spiketiming- dependent LTP and LTD in the CA1 area of hippocampal slices using optional imaging (2005)
  • Author(s): Tsukada M, Aihara T, Kobayashi Y, Shimazaki H
  • Journal Title: Hippocampus 15 Pages: 104-109
  • Peer Reviewed
• [Journal Article] GSK-3βRegulates Phosphorylation of CRMP-2 and Neuronal Polarity (2005)
  • Author(s): Yoshimura T, Kawano Y, Arimura N, Kawabata S, Kikuchi A, Kaibuchi K
  • Journal Title: Cell 120(1) Pages: 137-149
  • Peer Reviewed
• [Remarks]
  • URL: http://www.togo-nou.nips.ac.jp/