A research on a type of motor control by the cerebellum

2009 Fiscal Year Final Research Report

• Project/Area Number: 17022033
• Research Category: Grant-in-Aid for Scientific Research on Priority Areas
• Allocation Type: Single-year Grants
• Review Section: Biological Sciences
• Research Institution: Juntendo University
• Principal Investigator: KITAZAWA Shigeru Juntendo University, 医学部, 教授 (00251231)
• Co-Investigator(Kenkyū-buntansha): TAKAHASHI Toshimitsu 順天堂大学, 医学部, 助教 (00250704) ; LU Xiao-fan 順天堂大学, 医学部, 客員准教授 (20360703) ; TAKASHIMA Ichiro 産業技術総合研究所, 脳神経情報研究部門, 研究員 (90357351) ; NISHIMORI Yasunori 産業技術総合研究所, 脳神経情報研究部門, 研究員 (00357724) ; INOUE Masato 順天堂大学, 医学部, 助教 (10423047)
• Project Period (FY): 2005 – 2009
• Keywords: 小脳 / 運動制御 / 最適化 / プルキンエ細胞 / 単純スパイク / サッカード

Research Abstract

We investigated how the cerebellum contributes to the generation of smooth motor commands. For this purpose, we carried out experiments in arm and eye movements. As a result, we showed that simple spike activities recorded from Purkinje cells in the cerebellum encoded dynamics of the arm movements. The results support the hypothesis that the cerebellum optimizes dynamics of the movements. As for eye movements, we estimated onset times, directions and amplitudes of saccadic eye movements from the neural activities recorded from cerebral cortices. We were successful in calculating optimized motor commands to achieve the estimated eye movements.

Research Products

• [Journal Article] Neuronal activity related to anticipated and elapsed time in macaque supplementary eye field. (2008)
  • Author(s): Ohmae, S., Lu, X., Takahashi, T., Uchida, Y., Kitazawa, S.
  • Journal Title: Exp. Brain Res. 184 Pages: 593-598
• [Journal Article] Neuronal activity related to reward size and rewarded target position in primate supplementary eye field. (2007)
  • Author(s): Uchida, Y., Lu, X., Ohmae, S., Takahashi, T., Kitazawa, S.
  • Journal Title: J. Neurosci. 27 Pages: 13750-13755
• [Journal Article] Encoding of movement dynamics by purkinje cell simple spike activity during fast arm movements under resistive and assistive force fields. (2007)
  • Author(s): Yamamoto, K., Kawato, M., Kotosaka, S. Kitazawa, S.
  • Journal Title: J. Neurophysiol. 97 Pages: 1588-1599
• [Journal Article] randomness and synchrony in climbing fiber signals. (2005)
  • Author(s): Kitazawa, S., Wolpert, D.M. Rhythmicity
  • Journal Title: Trends Neurosci. 28 Pages: 611-619
• [Presentation] Consolidation of after-effects in prism adaptation triggered by a one-hour break. (2008)
  • Author(s): Ochiai, T., Kitazawa, S.
  • Organizer: 38th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-17
• [Presentation] Estimating saccade timing and targets from neural activity: Comparison of the macaque frontal eye field and the supplementary eye field. (2008)
  • Author(s): Ohmae, S., Lu, X., Uchida, Y., Takahashi, T., Nishimori, Y., Kodaka, Y., Takashima, I., Kitazawa S.
  • Organizer: 38th Annual meeting of the Society for Neuroscience
  • Place of Presentation: Washington DC, USA
  • Year and Date: 2008-11-17
• [Presentation] 到達運動における小脳プルキンエ細胞の情報表現. (2007)
  • Author(s): 北澤茂
  • Organizer: 玉川大学脳科学研究所設立記念シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2007-05-19
• [Book] Lecture Notes In Computer Science(Natural conjugate gradient on complex flag manifolds for complex independent subspace analysis., 5163) (2008)
  • Author(s): Nishimori, Y., Akaho, S., Plumbley, M.D.
  • Total Pages: 165-174
• [Remarks] ホームページ等
  • URL: http://square.umin.ac.jp/physio-1/