Evolution of Drug Discovery Targeting for G-protein Coupled Receptors

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 17209004
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Kyoto University
• Principal Investigator: FUJII Nobutaka Kyoto University, Graduate School of Pharmaceutical Sciences, Professor (60109014)
• Co-Investigator(Kenkyū-buntansha): OISHI Shinya Kyoto University, Graduate School of Pharmaceutical Sciences, Assistant Professor (80381739) ; 渡部 毅 京都大学, 薬学研究科, 研究員 (00397788)
• Project Period (FY): 2005 – 2007
• Keywords: Seven transmembrane protein / chemical proteomics / CXCR4 / T140 / G-protein coupled receptor

Research Abstract

In recent drug discovery researches, rational drug design is one of principal approaches to develop pharmaceutical agents. Recent progressive structural analyses of enzyme-substrate or receptor-ligand complex by X-ray crystallography have practically contributed to the inhibitor or antagonist designs. With increase in numbers of disclosed natural and unnatural peptide ligands from genome/proteome researches, this technique is increasingly expected to be an attractive methodology to find out lead compounds rationally, as well as random screening. Meanwhile, in the case of membrane protein ligands, it is much more difficult to assume what functional groups could be the pharmacophore, because exact structure analyses of these complexes are not available. In this program, we have engaged in evolutional development of technology for G-protein-coupled receptors, which are one of the major targets for recent drug discovery, including (1) establishment of chemical synthetic methodology for membrane proteins; (2) development of specific GPR54 ligands and the rational down-sizing; (3) development of efficient strategy for the preparation of non-peptide ligands.

Research Products

• [Journal Article] Stromal-derived factor l signalling regulates radial and tangential migration in the developing cerebral cortex. (2008)
  • Author(s): Liapi A., et al.
  • Journal Title: Dev. Neurosci. 30 Pages: 117-131
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Heplad repeal-derived peptides block prolease-medialcd direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway pathway. (2008)
  • Author(s): Ujike M., et al.
  • Journal Title: J. Virol. 80 Pages: 588-592
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Design of a novel HIV-1 fusion inhibitor that displays a minimal interface for binding affinity. (2008)
  • Author(s): Oishi S., et al.
  • Journal Title: J. Med. Chem. 51 Pages: 388-391
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptideisosteres by palladium-calalyzed carbonylation of amino acid-derived allylic carbonates. (2008)
  • Author(s): Inokuchi E., et al.
  • Journal Title: J. Org. Chem. 73 Pages: 3942-3945
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation. (2008)
  • Author(s): Ohta Y., et al.
  • Journal Title: Chem. Commun. 7 Pages: 835-837
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Synthesis and application of fluorescein- and botin-labeled molecular probes for chemokine receptor CXCR4. (2008)
  • Author(s): Oishi S., et al.
  • Journal Title: ChemBioChem 9 Pages: 1154-1158
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides. (2008)
  • Author(s): Ohno H., et al.
  • Journal Title: Org. Lett. 10 Pages: 1171-1174
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Diastereoseleclive synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to fmoc-based solid phase synthesis of a cyclic pentapeptide mimetic. (2008)
  • Author(s): Narumi T., et al.
  • Journal Title: Tetrahedron 64 Pages: 4332-4346
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Palladium-catalyzed sp3 C-H activation of simple alkyl groups : directpreparation of indoline derivatives from N-alkyl-2-bromoanilines. (2008)
  • Author(s): Watanabe T., et al.
  • Journal Title: Org. Lett. 10 Pages: 1756-1762
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating endothelial cells. (2008)
  • Author(s): Driessen W. H., et al.
  • Journal Title: Mol. Ther. 16 Pages: 516-524
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Stromal-derived factor 1 signalling regulates radial and tangential migration in the developing cerebral cortex. (2008)
  • Author(s): Liapi A., Pritchett J., Jones O., Fujii N., Parnavelas J. G., Nadarajah B.
  • Journal Title: Dev. Neurosci. 30 Pages: 117-131
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway pathway. (2008)
  • Author(s): Ujike M., Nishikawa H., Otaka A., Yamamoto N., Yamamoto N., Matsuoka M., Kodama E., Fujii N., Taguchi F.
  • Journal Title: J. Virol. 82 Pages: 588-592
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Design of a novel HIV-1fusion inhibitor that displays a minimal interface for binding affinity. (2008)
  • Author(s): Oishi S., Ito S., Nishikawa H., Watanabe K., Tanaka M., Ohno H., Izumi K., Sakagami Y., Kodama E., Matsuoka M., Fujii N.
  • Journal Title: J. Med. Chem. 51 Pages: 388-391
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Efficient synthesis of trifluoromethyl and related trisubstituted alkene dipeptide isosteres by palladium-catalyzed carbonylation of amino acid-derived allylic carbonates. (2008)
  • Author(s): Inokuchi E., Narumi T., Niida A., Kobayashi K., Tomita K., Oishi S., Ohno H., Fujii N.
  • Journal Title: J. Org. Chem. 73 Pages: 3942-3945
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Facile synthesis of 3-(aminomethyl)isoquinolines by copper-catalysed domino four-component coupling and cyclisation. (2008)
  • Author(s): Ohta Y., Oishi S., Fujii N., Ohno H.
  • Journal Title: Chem. Commun. 7 Pages: 835-837
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis and application of fluorescein- and botin-labeled molecular probes for chemokine receptor CXCR4. (2008)
  • Author(s): Oishi S., Masuda R., Evans B., Ueda S., Goto Y., Ohno H., Hirasawa A., Tsujimoto G., Wang Z., Peiper S. C., Naito T., Kodama E., Matsuoka M., Fujii N.
  • Journal Title: Chem BioChem 9 Pages: 1154-1158
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Direct construction of bicyclic heterocycles by palladium-catalyzed domino cyclization of propargyl bromides. (2008)
  • Author(s): Ohno H., Okano A., Kosaka S., Tsukamoto K., Ohata M., Ishihara K., Maeda H., Tanaka T., Fujii N.
  • Journal Title: Org. Lett. 10 Pages: 1171-1174
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Diastereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres and its application to fmoc-based solid phase synthesis of a cyclic pentapeptide mimetic. (2008)
  • Author(s): Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
  • Journal Title: Tetrahedron 64 Pages: 4332-4346
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Palladium-catalyzed sp3 C-H activation of simple alkyl groups: direct preparation of indoline derivatives from N-alkyl-2-bromoanilines. (2008)
  • Author(s): Watanabe T., Oishi S., Fujii N., Ohno H.
  • Journal Title: Org. Lett. 10 Pages: 1759-1762
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of peptide-targeted lipoplexes to CXCR4-expressing rat glioma cells and rat proliferating, endothelial cells. (2008)
  • Author(s): Driessen W. H., Fujii N., Tamamura H., Sullivan S. M.
  • Journal Title: Mol. Ther. 16 Pages: 516-524
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activily relationships of cyclic peplide-based chemokine receptor CXCR4antagonists : disclosing the importance of side-chain and backbone functionalities. (2007)
  • Author(s): Ueda S., et al.
  • Journal Title: J. Med. Chem. 50 Pages: 192-198
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra-and pentapeptide-scaffolds towards the treatment of HIV infection. cancer metastasis and rheumatoid arthritis. (2007)
  • Author(s): Tamamura H., et al.
  • Journal Title: Curr. Med. Chem. 14 Pages: 93-102
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Bromoallenes as allyl dicalion equivalents in the presence or absence of palladium(0) : direct construction of bicyclic sulfamides containing live- to eight-membered rings by tandem cyclization of bromoallenes. (2007)
  • Author(s): Hamaguchi H., et al.
  • Journal Title: Chem-Eur. J. 18 Pages: 1692-1708
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Inhibitors of the chemokine receptor CXCR4 : chemotherapy of AIDS, metastatic cancer, leukemia and rheumatoid arthritis. (2007)
  • Author(s): Tsutsumi H., et al.
  • Journal Title: Lett. Drug Design Discov. 4 Pages: 20-26
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Direct assessment of CXCE4 mutant conformations reveals complex link between receptor structure and Gαi activation. (2007)
  • Author(s): Berchiche Y. A., et al.
  • Journal Title: J. Biol. Chem. 282 Pages: 5111-5115
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Direct synthesis of 2-(aminomethyl) indoles through copper(I)-catalyzed domino three-component coupling and cyclization reactions. (2007)
  • Author(s): Ohno H., et al.
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 2295-2298
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The therapeutic potential of the chemokine receptor CXCR4 antagonists as multi-functional agents. (2007)
  • Author(s): Tsutsumi H., et al.
  • Journal Title: Biopolymers 88 Pages: 279-289
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres. (2007)
  • Author(s): Tomita K., et al.
  • Journal Title: Biopolymers 88 Pages: 272-278
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Synthesis of (Z)-alkene-containing cis-proline dipeptide mimetics using samarium (II) diiodide (SmI2)-mediated reductive-alkylation reaction. (2007)
  • Author(s): Sasaki Y., et al.
  • Journal Title: Tetrahedron 63 Pages: 2000-2008
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment. (2007)
  • Author(s): Juarez J., et al.
  • Journal Title: Leukemia 21 Pages: 1249-1257
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel oxazolidine linker for the synthesis of peptide aldehydes. (2007)
  • Author(s): Tanaka M., et al.
  • Journal Title: Int. J. Pep. Res. Ther. 13 Pages: 271-279
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A highly regio- and slereoselective formation of bicyclo [4.2.0] oct-5-ene derivatives through thermal intramolecular [2+2] cycloaddition of allenes. (2007)
  • Author(s): Ohno H., et al.
  • Journal Title: J. Org. Chem. 72 Pages: 4378-4389
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] SAR and QSAE studies on the N-terminally acylated pentapeptide agonists for GPR54. (2007)
  • Author(s): Tomita K., et al.
  • Journal Title: J. Med. Chem. 50 Pages: 3222-3228
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Rapid hematopoietic progenitor mobilization by sulfated colominic acid. (2007)
  • Author(s): Arenzana-Seisdedos F., et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 355 Pages: 970-975
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of copper-mediated allylation of γ-activated-α, β-unsaturated lactam toward peptide mimetic synthesis. (2007)
  • Author(s): Sasaki Y., et al.
  • Journal Title: Tetrahedron Lett. 48 Pages: 3221-3224
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Establishment and clinical application of enzyme immunoassays for determination of luteinizing hormone releasing hormone and metastin. (2007)
  • Author(s): Katagiri F., et al.
  • Journal Title: J. Pept. Sci. 13 Pages: 422-429
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists. (2007)
  • Author(s): Cluzeau J., et al.
  • Journal Title: Org. Biomol. Chem. 5 Pages: 1915-1923
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Systematic solution-phase parallel synthesis of active vitamin D3 analogs with elongated side chains and their cell differentiation activities. (2007)
  • Author(s): Ono Y., et al.
  • Journal Title: J. Comb. Chem. 9 Pages: 711-716
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Synthesis and biological evaluation of L-cysteint derivatives as mitotic kinesin Eg5 inhibitors. (2007)
  • Author(s): Ogo N., et al.
  • Journal Title: Bioorg. Med. Chem. Lett. 17 Pages: 3921-3934
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells. (2007)
  • Author(s): Kabashima K., et al.
  • Journal Title: Am. J. Pathol. 171 Pages: 1249-1257
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis. (2007)
  • Author(s): Zhang W., et al.
  • Journal Title: Mol. Pharmacol. 72 Pages: 1310-1321
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling. (2007)
  • Author(s): Kohara H., et al.
  • Journal Title: Blood 110 Pages: 4153-4160
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Versatile use of acid-catalyzed. ring-opening of β-aziridinyl-α β enoates to stereoselective synthesis of peptidomimetics. (2007)
  • Author(s): Tamamura H., et al.
  • Journal Title: Tetrahedron 63 Pages: 9243-9254
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Heck-type cyclization of oxime ethers : stereoselective carbon-carbon bondformation with aryl halides to produce heterocyclic oximes. (2007)
  • Author(s): Ohno H., et al.
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 6325-6328
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Modulation of network-driven, GABA-mediated giant depolarizing potentials by SDF-1α in the developing hippocampus. (2007)
  • Author(s): Kasiyanov A., et al.
  • Journal Title: Dev. Neurosci. 30 Pages: 285-292
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling. (2007)
  • Author(s): Watanabe T., et al.
  • Journal Title: Chem. Commun. Pages: 4516-4518
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Facile synthesis of fluoroalkenes by palladium-catalyzed reductive defluorination of allylic gem-difluorides. (2007)
  • Author(s): Karumi T., et al.
  • Journal Title: Org. Lett. 9 Pages: 3465-3468
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] CXCR4 engagement promotes dendritic cell survival and maturation. (2007)
  • Author(s): Kabashima K., et al.
  • Journal Title: Biochem. Biophys. Res. Commun. 361 Pages: 1012-1016
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Zipper-mode double C-H activation : palladium-catalyzed direct construction of highly-fused heterocyclic systems. (2007)
  • Author(s): Ohno H., et al.
  • Journal Title: Org. Lett. 9 Pages: 4813-4815
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Gold-catalyzed hydroarylation of allenes : a highly regioselective carbon-carbon bond formation producing six-membered rings. (2007)
  • Author(s): Watanabe T., et al.
  • Journal Title: Org. Lett. 9 Pages: 4821-4824
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structureactivity relationships of cyclic peptide-based chemokine receptor CXCR4 antagonists : disclosing the importance of side-chain and hackbone (2007)
  • Author(s): Ueda S., Oishi S., Wang Z. X., Araki T., Tamamura H., Cluzeau J., Ohno H. Kusano S., Nakashima H., Trent J. O., Peiper S. C., Fujii N.
  • Journal Title: J. Med. Chem. 50 Pages: 192-198
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of low molecular weight CXCR4 antagonists by exploratory structural tuning of cyclic tetra- and pentapeptide-scaffolds towards the treatment of HIV infection, cancer metastasis and rheumatoid arthritis. (2007)
  • Author(s): Tamamura H., Tsutsumi H., Masuno H., Fujii N.
  • Journal Title: Curr. Med. Chem. 14 Pages: 93-102
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bromoallenes as allyl dication equivalents in the presence or absence of palladium(O) : direct construction of bicyclic sulfamides containing five- to eight-membered rings by tandem cyclization of bromoallenes. (2007)
  • Author(s): Hamaguchi H., Kosaka S., Ohno H., Fujii N., Tanaka T.
  • Journal Title: Chem-Eur. J. 13 Pages: 1692-1708
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Inhibitors of the chemokine receptor CXCE4 : chemotherapy of AIDS, metastatic cancer, leukemia and rheumatoid arthritis. (2007)
  • Author(s): Tsutsumi H., Tamamura H., Fujii N.
  • Journal Title: Lett. Drug Design Discov. 4 Pages: 20-26
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Direct assessment of CXCR4 mutant conformations reveals complex link between receptor structure and Gai activation. (2007)
  • Author(s): Berchiche Y. A., Chow K. Y., Lagane B., Leduc M., Percherancier Y., Fujii N., Tamamura H., Bachelerie F., Heveker N.
  • Journal Title: J. Biol. Chem. 282 Pages: 5111-5115
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Direct synthesis of 2-(aminomethyl)indoles through copper(I)-catalyzed domino three-component coupling and cyclization reactions. (2007)
  • Author(s): Ohno H., Ohta Y., Oishi S., Fujii N.
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 2295-2298
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The therapeutic potential of the chemokine receptor CXCR4 antagonists as multi-functional agents. (2007)
  • Author(s): Tsutsumi H., Tanaka T., Ohashi N., Masuno H., Tamamura H., Hiramatsu K., Araki T., Ueda S., Oishi S., Fujii N.
  • Journal Title: Biopolymers 88 Pages: 279-289
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Fmoc-based solid-phase synthesis of GPR54-agonistic pentapeptide derivatives containing alkene- and fluoroalkene-dipeptide isosteres. (2007)
  • Author(s): Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
  • Journal Title: Biopolymers 88 Pages: 272-278
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of (Z)-alkenecontaining cis-proline dipeptide mimetics using samarium (II) diiodide (SmI2)-mediated reductive-alkylation reaction. (2007)
  • Author(s): Sasaki Y., Shigenaga A., Fujii N., Otaka A.
  • Journal Title: Tetrahedron 63 Pages: 2000-2008
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CXCR4 antagonists mobilize childhood acute lymphoblastic leukemia cells into the peripheral blood and inhibit engraftment. (2007)
  • Author(s): Juarez J., Dela Pena A., Baraz R., Hewson J., Khoo M., Cisterne A., Frickei S., Fujii N., Bradstock K. F., Bendall L. J.
  • Journal Title: Leukemia 21 Pages: 1249-1257
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel oxazolidine linker for the synthesis of peptide aldehydes. (2007)
  • Author(s): Tanaka M., Oishi S., Ohno H., Fujii N.
  • Journal Title: Int. J. Pep. Res. Ther. 13 Pages: 271-279
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A highly regio- and stereoselective formation of bicyclo[4.2.0]oct-5-ene derivatives through thermal intramolecular [2 + 2] cycloaddition of allenes. (2007)
  • Author(s): Ohno H., Mizutani T., Kadoh Y., Aso A., Miyamura K, Fujii N., Tanaka T.
  • Journal Title: J. Org. Chem. 72 Pages: 4378-4389
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] SAR and QSAR studies on the N-terminally acylated pentapeptide agonists for GPR54. (2007)
  • Author(s): Tomita K., Oishi S., Cluzeau J., Ohno H., Navenot J. M., Wang Z. X., Peiper S. C., Akamatsu M., Fujii N.
  • Journal Title: J. Med. Chem. 50 Pages: 3222-3228
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Rapid hematopoietic progenitor mobilization by sulfated colominic acid. (2007)
  • Author(s): Kubonishi S., Kikuchi T., Yamaguchi S., Tamamura H., Fujii N., Watanabe T., Arenzana-Seisdedos F., Ikeda K., Matsui T., Tanimoto M., Katayama Y.
  • Journal Title: Biochem. Biophys. Res. Commun. 355 Pages: 970-975
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of copper-mediated allylation of y-activated-a, B-unsaturated lactam toward peptide mimetic synthesis. (2007)
  • Author(s): Sasaki Y., Fujii N., Otaka A.
  • Journal Title: Tetrahedron Lett. 48 Pages: 3221-3224
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Establishment and clinical application of enzyme immunoassays for determination of luteinizing hormone releasing hormone and metastin. (2007)
  • Author(s): Katagiri F., Tomita K., Oishi S., Takeyama M., Fujii N.
  • Journal Title: J. Pept. Sci. 13 Pages: 422-429
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Design and synthesis of all diastereomers of cyclic pseudo-dipeptides as mimics of cyclic CXCR4 pentapeptide antagonists. (2007)
  • Author(s): Cluzeau J., Oishi S., Ohno H., Wang Z., Evans B., Peiper S. C., Fujii N.
  • Journal Title: Org. Biomol. Chem. 5 Pages: 1915-1923
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Systematc solution-phase parallel synthesis of active vitamin D3 analogs with elongated side chains and their cell differentiation activities. (2007)
  • Author(s): Ono Y., Kashiwagi H., Esaki T., Tadakatsu T., Sato H., Fujii N.
  • Journal Title: J. Comb. Chem. 9 Pages: 711-716
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis and biological evaluation of L-cysteine derivatives as mitotic kinesin Eg5 inhibitors. (2007)
  • Author(s): Ogo N., Oishi S., Matsuno K., Sawada J., Fujii N., Asai A.
  • Journal Title: Bioorg. Med. Chem. Lett. 17 Pages: 3921-3924
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CXCL12-CXCR4 engagement is required for migration of cutaneous dendritic cells (2007)
  • Author(s): Kabashima K., Shiraishi N., Sugita K., Mori T., Onoue A., Kobayashi M., Sakabe J., Yoshiki R., Tamamura H., Fujii N., Inaba K., Tokura Y.
  • Journal Title: Am. J. Pathol. 171 Pages: 1249-1257
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association of nucleophosmin negatively regulates CXCR4-mediated G protein activation and chemotaxis. (2007)
  • Author(s): Zhang W., Navenot J. M., Frilot N. M., Fujii N., Peiper S. C.
  • Journal Title: Mol. Pharmacol. 72 Pages: 1310-1321
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of plasmacytoid dendritic cells in bone marrow stromal cell niches requires CXCL12-CXCR4 chemokine signaling. (2007)
  • Author(s): Kohara H., Omatsu Y., Sugiyama T., Noda M., Fujii N., Nagasawa T.
  • Journal Title: Blood 110 Pages: 4153-4160
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Versatile use of acid-catalyzed ring-opening of □-aziridinyl-□, □ enoates to stereoselective synthesis of peptidomimetics. (2007)
  • Author(s): Tamamura H., Tanaka T., Tsutsumi H., Nemoto K., Mizokami S., Ohashi N., Oishi S., Fujii N.
  • Journal Title: Tetrahedron 63 Pages: 9243-9254
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Heck-type cyclization of oxime ethers : stereoselective carbon-carbon bond formation with aryl halides to produce heterocyclic oximes. (2007)
  • Author(s): Ohno H., Aso A., Kadoh Y., Fujii N., Tanaka T.
  • Journal Title: Angew. Chem. Int. Ed. 46 Pages: 6325-6328
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Modulation of networkdriven, GABA-mediated giant depolarizing potentials by SDF-1a in the developing hippocampus. (2007)
  • Author(s): Kasiyanov A., Fujii N., Tamamura H., Xiong H.
  • Journal Title: Dev. Neurosci. 30 Pages: 285-292
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling (2007)
  • Author(s): Watanabe T., Ueda S., Inuki S., Oishi S., Fujii N., Ohno H.
  • Journal Title: Chem. Commun. Pages: 4516-4518
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Facile synthesis of fluoroalkenes by palladium-catalyzed reductive defluorination of allylic gem-difluorides. (2007)
  • Author(s): Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
  • Journal Title: Org. Lett. 9 Pages: 3465-3468
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] CXCR4 engagement promotes dendritic cell survival and maturation. (2007)
  • Author(s): Kabashima K., Sugita K., Shiraishi N., Tamamura H., Fujii N., Tokura Y.
  • Journal Title: Biochem. Biophys. Kes. Commun. 361 Pages: 1012-1016
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Zipper-mode double C-H activation : palladium-catalyzed direct construction of highly-fused heterocyclic systems. (2007)
  • Author(s): Ohno H., Iuchi M., Fujii N., Tanaka T.
  • Journal Title: Org. Lett. 9 Pages: 4813-4815
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gold-catalyzed hydroarylation of allenes : a highly regioselective carbon-carbon bond formation producing sixmembered rings. (2007)
  • Author(s): Watanabe T., Oishi S., Fujii N., Ohno H.
  • Journal Title: Org. Lett. 9 Pages: 4821-4824
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Design and synthesis of downsized metastin (45-54) analogs with maintenanceof high GPR54 agonistic activity. (2006)
  • Author(s): Niida A., et al.
  • Journal Title: Bioorg. Med. Chem. Lett. 16 Pages: 134-137
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] HIV-1 gp120 enhances giant depolarizing potentials via chemokine receptorCXCR4 in neonatal rat hippocampus. (2006)
  • Author(s): Kasyanov A., et al.
  • Journal Title: Eur. J. Neurosci. 23 Pages: 1120-1128
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The involvement of stromal derived factor 1α in homing and progression ofmultiple myeloma in the 5TMM model. (2006)
  • Author(s): Menu E., et al.
  • Journal Title: Haematologica 91 Pages: 605-612
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Application of tri-and tetrasubstituted alkene dipeptide mimetics toconformational studies of cyclic RGD peptides. (2006)
  • Author(s): Oishi S., et al.
  • Journal Title: Tetrahedron 62 Pages: 1416-1424
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of a 111In-labeled peptide derivative targeting a chemokinereceptor, CXCR4, for imaging tumors. (2006)
  • Author(s): Hanaoka H., et al.
  • Journal Title: Nucl. Med. Biol. 33 Pages: 489-494
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Cysteine-derived S-protected oxazolidinones : potential chemical devices forthe preparation of peptide thioesters. (2006)
  • Author(s): Ohta Y., et al.
  • Journal Title: Org. Lett. 8 Pages: 467-470
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probestruclural requirements of the peptide transporter PEPT1. (2006)
  • Author(s): Niida A., et al.
  • Journal Title: Org. Lett. 8 Pages: 613-616
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Potassium carbonate-promoted stereospecific 5-endo-trig cyclization ofunactivated allenes in the absence of any transition metals. (2006)
  • Author(s): Ohno H., et al.
  • Journal Title: Org. Lett. 8 Pages: 947-950
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of antiviral fusion inhibiting peptides. (2006)
  • Author(s): Otaka A., et al.
  • Journal Title: Kagaku Kogyo 57 Pages: 797-801
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The chemokine receptor CXCR4 as a therapeutic target for several diseases. (2006)
  • Author(s): Tamamura H., et al.
  • Journal Title: Mini Rev. Med. Chem. 6 Pages: 989-995
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Idenlification of a new class of low molecular weight antagonists against the chemokinereceptor CXCR having the dipicolylauine-zinc(II) complex stuctur (2006)
  • Author(s): Tamamura H., et al.
  • Journal Title: J. Med. Chen. 49 Pages: 3412-3415
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Synlhesis of (Z)-alkene and (E)-fluoroalkene-containing dikelopiperazine nimelicsutilizing organocopper-mediated reduction-alkylation and diaslereoseleclivily examinationusing DFT calculations. (2006)
  • Author(s): Niida A., et al.
  • Journal Title: J. Org. Chem. 71 Pages: 4118-4129
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Transport characteristics of a novel PEPT1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. (2006)
  • Author(s): Tsuda M., el al.
  • Journal Title: J. Pharmacol. Exp. Ther. 318 Pages: 455-460
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Stereoselective synthesis of 3, 6-dvsubstituted-3, 6-dihydropyridin-2-ones as potcntial diketopiperazine mimetics using organocopper-mediated anti-SK2' reactions and their use in the preparation of low-molecule CXCR4 antagonists. (2006)
  • Author(s): Niida A., et al.
  • Journal Title: J. Org. Chem. 71 Pages: 3942-3951
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Development of a linear type of low molecular weight CXCE4 antagonists based on T140 analogs. (2006)
  • Author(s): Tamamura H., et al.
  • Journal Title: Org. Biomol. Chem. 4 Pages: 2354-2357
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics. (2006)
  • Author(s): Sasaki Y., et al.
  • Journal Title: J. Org. Chem. 71 Pages: 4969-4979
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structure-activity relationship study on small peptidic GPR54 agonists. (2006)
  • Author(s): Tomita K., et al.
  • Journal Title: Bioorg. Med. Chem. 14 Pages: 7595-7603
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeplide isosteres. (2006)
  • Author(s): Narumi T., et al.
  • Journal Title: Chem. Commun. Pages: 4720-4722
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Design and synthesis of downsized metastin (45-54) analogs with maintenance of high GPR54 agonistic activity (2006)
  • Author(s): Niida A., Wang Z., Tomita K, Oishi S., Tamamura H., Otaka A., Navenot J. M., Broach J. R., Peiper S. C., Fujii N.
  • Journal Title: Bioorg. Med. Chem. Lett. 16 Pages: 134-137
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] HIV-1 gpl20 enhances giant depolarizing potentials via chemokine receptor CXCR4 in neonatal rathippocampus. (2006)
  • Author(s): Kasyanov A., Tamamura H., Fujii N., Xiong H.
  • Journal Title: Eur. J. Neurosci. 23 Pages: 1120-1128
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The involvement of stromal derived factor la in homing and progression of multiple myeloma in the 5TMM model. (2006)
  • Author(s): Menu E., Asosingh K., Indraccolo S., De Raeve H., Van Riet I., Van Valckenborgh E., Van de Broek I, Fujii N., Tamamura H., Van Camp B., Vanderkerken K.
  • Journal Title: Haematologica 91 Pages: 605-612
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Application of tri- and tetrasubstituted alkene dipeptide mimetics to conformational studies of cyclic RGD peptides (2006)
  • Author(s): Oishi S., Miyamoto K., Niida A., Yamamoto M., Ajito K., Tamamura H., Otaka A., Kuroda Y., Asai A., Fujii N.
  • Journal Title: Tetrahedron 62 Pages: 1416-1424
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of a lllln-labeled peptide derivative targeting a chemokine receptor, CXCR4, for imaging tumors. (2006)
  • Author(s): Hanaoka H., Mukai T., Tamamura H., Mori T., Ishino S., Ogawa K., Iida Y., Doi R., Fujii N., Saji H.
  • Journal Title: Nucl. Med. Biol. 33 Pages: 489-494
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Cysteinederived S-protected oxazolidinones: potential chemical devices for the preparation of peptide thioesters. (2006)
  • Author(s): Ohta Y., Itoh S., Shigenaga A., Shintaku S., Fujii N., Otaka A.
  • Journal Title: Org. Lett. 8 Pages: 467-470
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Unequivocal synthesis of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres to probe structural requirements of the peptide transporter PEPT1. (2006)
  • Author(s): Niida A., Tomita K., Mizumoto M., Tanigaki H., Terada T., Oishi S., Otaka A., Inui K., Fujii N.
  • Journal Title: Org. Lett. 8 Pages: 613-616
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potassium carbonate-promoted stereospecific 5-endo-trig cyclization of unactivated allenes in the absence of any transition metals. (2006)
  • Author(s): Ohno H., Kadoh Y., Fujii N., Tanaka T.
  • Journal Title: Org. Lett. 8 Pages: 947-950
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of antiviral fusion inhibiting peptides. (2006)
  • Author(s): Otaka A., Fujii N.
  • Journal Title: Kagaku Kogyo 57 Pages: 797-801
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The chemokine receptor CXCR4 as atherapeutic target for several diseases. (2006)
  • Author(s): Tamamura H., Tstsumi H., Fujii N.
  • Journal Title: Mini Rev. Med. Chem. 6 Pages: 989-995
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of a new class of low molecular weight antagonists against the chemokine receptor CXCR4 having the dipicolylamine-zinc(II) complex structure. (2006)
  • Author(s): Tamamura H., Ojida A., Ogawa T., Tsutsumi H., Masuno H., Nakashima H., Yamamoto N., Hamachi I., Fujii N.
  • Journal Title: J. Med. Chem. 49 Pages: 3412-3415
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of (Z)-alkene and (E)-fluoroalkenecontaining diketopiperazine mimetics utilizing organocopper-mediated reduction-alkylation and diastereoselectivity examination using DFT (2006)
  • Author(s): Niida A., Mizumoto M., Narumi T., Inokuchi E., Oishi S., Ohno H., Otaka A., Kitaura K., Fujii N.
  • Journal Title: J. Org. Chem. 71 Pages: 4118-4129
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Transport characteristics of a novel PEPT1 substrate, antihypotensive drug midodrine, and its amino acid derivatives. (2006)
  • Author(s): Tsuda M., Terada T., Me M., Katsura T., Niida A., Tomita K., Fujii N., Inui K.
  • Journal Title: J. Pharmacol. Exp. Ther. 318 Pages: 455-460
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Stereoselective synthesis of 3,6-disubstituted-3,6-dihydropyridin-2-ones as potential diketopiperazine mimetics using organocopper-mediated anti-SN2' reactions and their use in the preparation of low-molecule CXCR4 antagonists. (2006)
  • Author(s): Niida A., Tanigaki H., Inokuchi E., Sasaki Y., Oishi S., Ohno H., Tamamura H., Wang Z., Peiper S. C., Kitaura K., Otaka A., Fujii N.
  • Journal Title: J. Org. Chem. 71 Pages: 3942-3951
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Development of a linear type of low molecular weight CXCR4 antagonists based on T140 analogs. (2006)
  • Author(s): Tamamura H., Tsutsumi H., Masuno H., Mizokami S., Hiramatsu K., Wang Z., Trent J. O., Nakashima H., Yamamoto N., Peiper S. C., Fujii N.
  • Journal Title: Org. Biomol. Chem. 4 Pages: 2354-2357
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Stereoselective synthesis of (Z)-alkene-containing proline dipeptide mimetics (2006)
  • Author(s): Sasaki Y., Niida A., Tsuji T., Shigenaga A., Fujii N., Otaka A.
  • Journal Title: J. Org. Chem. 71 Pages: 4969-49679
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activity relationship study on small peptidic GPR54 agonists. (2006)
  • Author(s): Tomita K., Niida A., Oishi S., Ohno H., Cluzeau J., Navenot J. M., Wang Z. X., Peiper S. C., Fujii N.
  • Journal Title: Bioorg. Med. Chem. 14 Pages: 7595-7603
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A novel one-pot reaction involving organocopper-mediated reduction/transmetalation/asymmetric alkylation, leading to the diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres. (2006)
  • Author(s): Narumi T., Niida A., Tomita K., Oishi S., Otaka A., Ohno H., Fujii N.
  • Journal Title: Chem. Commun. Pages: 4720-4722
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] New HIV-drug inhibits in vitro bladder cancer migration and invasion. (2005)
  • Author(s): Retz M., et al.
  • Journal Title: Eur. Urol. 48 Pages: 1025-1030
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Kisspeptin-10-induced signaling of GPE54 negatively regulates chemotactic responsesmediated by CXCR4 : a potential mechanism for the melaslasis suppressor activity ofkisspeptins. (2005)
  • Author(s): Navenot J. M., et al.
  • Journal Title: Cancer Res. 65 Pages: 10450-10456
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Photolabile protection for one-pot sequential native chemical ligation. (2005)
  • Author(s): Ueda S., et al.
  • Journal Title: ChemBioChem 6 Pages: 1983-1986
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] structure-activity relationship studies on CXCR4 antagonists having cyclicpentapeptide scaffolds. (2005)
  • Author(s): Tamamura H., et al.
  • Journal Title: Org. Biomol. Chem. 3 Pages: 4392-4394
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The therapeutic potential of CXCR4 antagonists in the treatment of HIVinfection, cancer metastasis and rheumatoid arthritis. (2005)
  • Author(s): Tamamura H., et al.
  • Journal Title: Exp. Opin. Ther. Target 9 Pages: 1267-1282
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Innovative platform for drug discovery based on chemical proteomics : fromknowledge to controlling. (2005)
  • Author(s): Fuj ii N., et al.
  • Journal Title: Saibo Kogaku 24 Pages: 1181-1186
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] New HIV-drug inhibits in vitro bladder cancer migration and invasion. (2005)
  • Author(s): Retz M., Sidhu S. S., Lehmann J., Tamamura H., Fujii N., Basbaum C.
  • Journal Title: Eur. Urol. 48 Pages: 1025-1030
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Kisspeptin-10induced signaling of GPR54 negatively regulates chemotactic responses mediated by CXCR4: a potential mechanism for the metastasis suppressor activity of kisspeptins. (2005)
  • Author(s): Navenot J. M., Wang Z., Chopin M., Fujii N., Peiper S. C.
  • Journal Title: Cancer Res. 65 Pages: 10450-10456
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Photolabile protection for one-pot sequential native chemical ligation. (2005)
  • Author(s): Ueda S., Pujita M., Tamamura H., Fujii N., Otaka A.
  • Journal Title: ChemBioChem 6 Pages: 1983-1986
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activity relationship studies on CXCR4 antagonists having cyclic pentapeptide scaffolds. (2005)
  • Author(s): Tamamura H., Esaka A., Ogawa T., Araki T., Ueda S., Wang Z., Trent J. O., Tsutsumi H., Masuno H., Nakashima H., Yamamoto N., Peiper S. C., Otaka A., Fujii N.
  • Journal Title: Org. Biomol. Chem. 3 Pages: 4392-4394
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The therapeutic potential of CXCR4 antagonists in the treatment of HIV infection, cancer metastasis and rheumatoid arthritis (2005)
  • Author(s): Tamamura H., Fujii N.
  • Journal Title: Exp. Opin. Ther. Target 9 Pages: 1267-1282
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Innovative platform for drug discovery based on chemical proteomics: from knowledge to controlling. (2005)
  • Author(s): Fujii N., Otaka A., Tamamura H.
  • Journal Title: Saibo Kogaku 24 Pages: 1181-1186
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists.
  • Author(s): Tomita K., et al.
  • Journal Title: Biopolymers in press
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structure-activity relationship of pyrazine-based CK2 inhibitors : synthesis and biological evaluation of 2, 6-disubstituted pyrazine and 4, 6-disubstituted pyrimidine derivatives.
  • Author(s): Suzuki Y., et al.
  • Journal Title: Archiv. Pharm. in press
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Potent synergistic anti-HIV effects using combinations of a CCR5. inhibitor aplaviroc with other anti-HIV drugs.
  • Author(s): Nakata H., et al.
  • Journal Title: Antimicrob. Agents. Chemother. in press
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41.
  • Author(s): Nishikawa H., et al.
  • Journal Title: AntiYir. Res. in press
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Palladium-catalysed biscyclisation of allenic bromoalkenes through zipper- mode cascade.
  • Author(s): Okano A., et al.
  • Journal Title: Chem. Commun. in press
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Identification of novel nonpeptide CXCR4 antagonists by ligand-based design approach.
  • Author(s): Ueda S., et al.
  • Journal Title: Bioorg. Med. Chem. Lett. in press
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Coiled-coil tag-probe system for quick labeling of membrane receptors in living cells.
  • Author(s): Yano Y., et al.
  • Journal Title: ACS Chem. Biol. in press
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structure-activity relationship study and NMR analysis of fluorobenzoyl pentapeptide GPR54 agonists.
  • Author(s): Tomita K., Oishi S., Ohno H., Fujii N.
  • Journal Title: Biopolymers (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structure-activity relationship of pyrazine-based CK2 inhibitors : synthesis and biological evaluation of 2,6-disubstituted pyrazine and 4,6-disubstituted pyrimidine derivatives.
  • Author(s): Suzuki Y., Cluzeau J., Hara T., Hirasawa A.. Tsujimoto G., Oishi S., Ohno H., Fujii N.
  • Journal Title: Archiv. Pharm. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Potent synergistic anti-HIV effects using combinations of a CCR5. inhibitor aplaviroc with other anti-HIV drugs.
  • Author(s): Nakata H., Steinberg S. M., Koh Y., Maeda K., Takaoka Y, Tamamura H., Fujii N., Mitsuya H.
  • Journal Title: Antimicroh. Agents. Chemother. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel screening systems for HIV-1 fusion mediated by two extra-virion heptad repeats of gp41.
  • Author(s): Nishikawa H., Kodama E., Sakakibara A., Fukudome A., Izumi K., Oishi S., Fujii N., Matsuoka M.
  • Journal Title: Antivir. Res. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Palladiumcatalysed biscyclisation of allenic bromoalkenes through zipper-mode cascade.
  • Author(s): Okano A., Mizutani T., Oishi S., Tanaka T., Ohno H., Fujii N.
  • Journal Title: Chem. Commun. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Identification of novel nonpeptide CXCR4 antagonists by ligand-based design approach.
  • Author(s): Ueda S., Kato M., Inuki S., Ohno H., Evans B., Wang Z., Peiper S. C., Izumi K., Kodama E., Matsuoka M., Nagasawa H., Oishi S., Fujii N.
  • Journal Title: Bioorg. Med. Chem. Lett. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Coiled-coil tag-probe system for quick labeling of membrane receptors in living cells.
  • Author(s): Yano Y., Yano A., Oishi S., Sugimoto Y., Tsujimoto G., Fujii N., Matsuzaki K.
  • Journal Title: ACS Chem. Biol. (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の創製と応用 (2008)
  • Author(s): 増田亮, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第3回年会
  • Place of Presentation: 東京
  • Year and Date: 20080519-20080520
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ピラジンを母核とするCK2阻害剤の構造活性相関研究 (2008)
  • Author(s): 鈴木大和, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第3回年会
  • Place of Presentation: 東京
  • Year and Date: 20080519-20080520
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 環状ペプチドをリードとする非ペプチド性CXCR4拮抗剤の開発 (2008)
  • Author(s): 大石真也, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第3回年会
  • Place of Presentation: 東京
  • Year and Date: 20080519-20080520
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規フアルマコフォアを有するケモカインレセプターCXCR4アンタゴニストの構造活性相関研究 (2008)
  • Author(s): 田中智博, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第3回年会
  • Place of Presentation: 東京
  • Year and Date: 20080519-20080520
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis and application of fluorescent CXCR4 antagonist (2008)
  • Author(s): Masuda R., Oishi S., Ueda S., Evans B., Peiper SC, Hirasawa A., Tsujimoto G., Ohno H., Fujii N.
  • Organizer: 3rd Annual Meeting of Japan Chemical Biology Society
  • Place of Presentation: Tokyo
  • Year and Date: 20080519-20080520
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-activity relathionship on pyrazine-based CK2 inhibitors (2008)
  • Author(s): Suzuki Y., Jerome Cluzeau, Hara T., Hirasawa A., Tsujimoto G., Oishi S., Ohno H., Fujii N.
  • Organizer: 3rd Annual Meeting of Japan Chemical Biology Society
  • Place of Presentation: Tokyo
  • Year and Date: 20080519-20080520
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of novel non-peptide CXCR4 antagonists based on cyclic peptide structure (2008)
  • Author(s): Oishi S., Katoh M., Ueda S., Inuki S., Ohno H., Barry Evans, Zi-xuan Wang, Stephen C. Peiper, Fujii N.
  • Organizer: 3rd Annual Meeting of Japan Chemical Biology Society
  • Place of Presentation: Tokyo
  • Year and Date: 20080519-20080520
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-activity relationship on CXCR4 antagonists having novel pharmacophores (2008)
  • Author(s): Tanaka T., Nomura W., Tsutsumi H., Tabe Y., Ohhashi N., Itoya K., Oishi S., Fujii N., Evans B., Wang Z., Peiper SC, Tamamura H.
  • Organizer: 3rd Annual Meeting of Japan Chemical Biology Society
  • Place of Presentation: Tokyo
  • Year and Date: 20080519-20080520
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] T-20 (Fuzeon)耐性HIV-1変異株における6-ヘリカルバンドル構造のX線結晶構造解析 (2008)
  • Author(s): 渡部毅, et al.
  • Organizer: 日本化学会第88春季年会
  • Place of Presentation: 東京
  • Year and Date: 20080326-20080330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] X-ray crystal structure analysis of 6-helical bundle structure of T-20 (Fuzeon) -resistant HIV mutants (2008)
  • Author(s): Watabe T., Oishi S., Nishikawa H., Watanabe K., Nakano H., Nakatsu T., Ohno H., Katoh H., Kodama E., Matsuoka M., Fujii N.
  • Organizer: 88th Spring meeting of the chemical society of Japan
  • Place of Presentation: Tokyo
  • Year and Date: 20080326-20080330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] シス型アミド結合等価体としてのZ型アルケンおよびE型フルオロアルケンジペプチドイソスターの合成と応用 (2008)
  • Author(s): 富田健嗣, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規pharmacophoreを有するCXCR4アンタゴニストの構造活性相関研究 (2008)
  • Author(s): 田中智博, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 化合物-タンパク質相互作用情報に基づく新規in silico化合物探索手法の開発 (2008)
  • Author(s): 小川哲平, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規生細胞膜受容体蛍光ラベル法 : コイルドコイルタグープローブペア (2008)
  • Author(s): 矢野義明, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ピラジンを母核とするCK2阻害剤の構造活性相関研究 (2008)
  • Author(s): 鈴木大和, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 求核的CF3化反応による立体選択的トリフルオロメチルアルケン型ジベペプチドイソスターの合成 (2008)
  • Author(s): 小林数也, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築 (2008)
  • Author(s): 井貫晋輔, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の合成と応用 (2008)
  • Author(s): 増田亮, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヘリックス誘起モチーフを導入した抗HIVペプチドのデザインと合成 (2008)
  • Author(s): 渡辺健太郎, et al.
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis and application of Z-alkene and E-fluoroalkene dipeptide isosteres as cis-amide bond equivalents (2008)
  • Author(s): Tomita K, Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-activity relationship on CXCR4 antagonists having novel pharmacophores (2008)
  • Author(s): Tanaka T., Tabe Y., Ohhashi N., Haseyama M., Tsutsumi H., Nomura W., Itoya K., Esaka R.,Oishi S., Fujji N., Wang Z., Peiper SC, Evans B., Tamamura H.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of novel in silico technology based on compounds-protein interactions (2008)
  • Author(s): Ogawa T., Kitajima M., Minowa Y., Matsuda H., Fujii N., Okuno Y.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Novel labeling protocol for cell-membrane proteins by tag-probe method- (2008)
  • Author(s): Yano Y., Yano A., Oishi S., Sugimoto Y., Tsujimoto G., Fujii N., Matsuszaki K.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-activity relathionship on pyrazine-based CK2 inhibitors (2008)
  • Author(s): Suzuki Y., Cluzeau J., Oishi S., Ohno H., Fujii N., Hara T., Hirasawa A., Tsujimoto G.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stereoselective synthesis of trifluoromethylalkene dipeptide isosteres by nucliophilic CF3-introduction (2008)
  • Author(s): Kobayashi K., Narumi T., Inokuchi E., Tomita K., Oishi S., Ohno H., Fujii N.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of ergot alkaloids by paradium-catalyzed domino cyclizations of allenes (2008)
  • Author(s): Inuki S., Oishi S., Fuji N., Ohno H.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and application of fluorescent CXCR4 antagonist (2008)
  • Author(s): Masuda R., Oishi S., Ueda S., Barry Evans, Stephen C. Peiper, Hirasawa A., Tsujimoto G., Ohno H., Fujii N.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Design and synthesis of anti-HIV peptides having helix-inducible motifs (2008)
  • Author(s): Watanabe K., Oishi S., Itoh S., Tanaka M., Hishikawa H., Watabe T., Izumi K., Sakagami Y., Kodama E., Matsuoka M., Ohno H., Fujii N.
  • Organizer: The 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama
  • Year and Date: 20080326-20080328
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Chemical Virologyを基盤とする新興・再興ウイルス侵入阻害剤の開発研究 (2008)
  • Author(s): 藤井信孝
  • Organizer: 第4回ケミカルバイオロジーシンボジウムー化学-生物融合領域創成の軌跡-
  • Place of Presentation: 熱海
  • Year and Date: 20080207-20080208
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of anti viral agents of emerging and re-emerging viruses based on chemical virology (2008)
  • Author(s): Fujii N.
  • Organizer: The 4th Chemical Biology Symposium
  • Place of Presentation: Atami
  • Year and Date: 20080207-20080208
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] CCA空間モデルを用いた化合物-CYP相互作用予測モデルの構築 (2008)
  • Author(s): 小川哲平, et al.
  • Organizer: 第5回バイオメディカル研究会
  • Place of Presentation: 大阪
  • Year and Date: 2008-02-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Model development for virtual screening of CYP-interactive compounds using CCA spatial model (2008)
  • Author(s): Ogawa T., Minowa Y., Adachi T., Feng C, Niijima S., Oishi S., Fujii N., Okuno Y.
  • Organizer: 5th Seminars on Biomedical Researches
  • Place of Presentation: Osaka
  • Year and Date: 2008-02-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ライブラリー(General Library)化合物の選択 (2008)
  • Author(s): 安野和浩, et al.
  • Organizer: ターゲットタンパク研究プログラム第1回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-02-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Gタンパク共役型受容体に対する制御化合物探索に関わる化合物評価基盤技術の確立と立証-新規生細胞膜受容体蛍光ラベル法の開発 : コイルドコイル形成タグープローブ法- (2008)
  • Author(s): 矢野義明, et al.
  • Organizer: ターゲットタンパク研究プログラム第1回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-02-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 抗がん剤リード化合物探索のためのスクリーニング系の開発と実証-HIF-1分子標的薬の開発- (2008)
  • Author(s): 服部明, et al.
  • Organizer: ターゲットタンパク研究プログラム第1回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-02-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 化合物の提供と新規フラグメント化合物群の創製による化合物ライブラリー充実への貢献-ドラッグライク構造を有する多置換型複素環の効率的合成法の開発- (2008)
  • Author(s): 藤井信孝, et al.
  • Organizer: ターゲットタンパク研究プログラム第1回公開シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 2008-02-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Selection of Chemicals for General Library (2008)
  • Author(s): Yasuno K., Kojima H., Okabe T., Oishi S., Fujii N., Nagano T. Furuya T.
  • Organizer: The 1st Symposium on Target Protein Research Program
  • Place of Presentation: Tokyo
  • Year and Date: 2008-02-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Establishment of bioevaluation technology for drug discovery for GPCR -novel labeling protocol for cell-membrane proteins by tag-probe method- (2008)
  • Author(s): Yano Y., Oishi S., Sugimoto Y., Tsujimoto G., Fujii N., Matsuzaki K.
  • Organizer: The 1st Symposium on Target Protein Research Program
  • Place of Presentation: Tokyo
  • Year and Date: 2008-02-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of screening system for anti-cancer lead compounds -for HIF-1-targeting agents - (2008)
  • Author(s): Hattori A., Yagura T., Nishimura S., Oishi S., Fujii N., Kakeya H.
  • Organizer: The 1st Symposium on Target Protein Research Program
  • Place of Presentation: Tokyo
  • Year and Date: 2008-02-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Contribution to chemical library by preparation of novel fragment compound -efficient synthesis of multi-substituted heterocycles having drug-like strucure- (2008)
  • Author(s): Fujii N., Ohno H., Oishi S., Takemoto Y., Takasu K, Yasui Y., Tomioka K., Yamada K., Yamamoto Y.
  • Organizer: The 1st Symposium on Target Protein Research Program
  • Place of Presentation: Tokyo
  • Year and Date: 2008-02-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of nitrogen heterocycles by palladium-catalyzed sp3 C-Hactivation (2008)
  • Author(s): Toshiaki Watanabe, et al.
  • Organizer: The 9th Youngnam-Kinki Joint Symposium on Organometallic Chemistry
  • Place of Presentation: 京都
  • Year and Date: 2008-01-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of nitrogen heterocycles by palladium-catalyzed sp3 C-H activation. (2008)
  • Author(s): Toshiaki Watanabe, Shinya Oishi, Nobutaka Fujii, Hiroaki Ohno
  • Organizer: The 9th Youngnam-Kinki Joint Symposium on Organometallic Chemistry
  • Place of Presentation: Kyoto
  • Year and Date: 2008-01-25
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] C29水溶性誘導体SC29EKの抗HIV効果 (2007)
  • Author(s): 内藤武志, et al.
  • Organizer: 第21回日本エイズ学会学術集会・総会
  • Place of Presentation: 広島
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] T-20耐性変異を利用した融合阻害薬の開発 (2007)
  • Author(s): 泉和樹, et al.
  • Organizer: 第21回日本エイズ学会学術集会・総会
  • Place of Presentation: 広島
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] T-20誘導体の抗HIV効果 (2007)
  • Author(s): 嶋根和毅, et al.
  • Organizer: 第21回日本エイズ学会学術集会・総会
  • Place of Presentation: 広島
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規非ペプチド性ケモカイン受容体CXCR4アンタゴニストの創製研究 (2007)
  • Author(s): 加藤学, et al.
  • Organizer: 第26回メディシナルケミストリーシンポジウム
  • Place of Presentation: 相模原
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] シス型アミド結合等価体としてのZ型アルケンおよびE型フルオロアルケンジペプチドイソスターの合成と応用 (2007)
  • Author(s): 富田健嗣, et al.
  • Organizer: 第26回メディシナルケミストリーシンポジウム
  • Place of Presentation: 相模原
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Eg5阻害作用を有するシステイン誘導体の合成と構造活性相関 (2007)
  • Author(s): 小郷尚久, et al.
  • Organizer: 第26回メディシナルケミストリーシンポジウム
  • Place of Presentation: 相模原
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Anti-HIV activity of water-soluble analogue of C29, SC29EK (2007)
  • Author(s): Naitoh T., Izumi K., Kodama E., Oishi S., Fujii N., Matsuoka M.
  • Organizer: 21st Annual meeting of the Japan Society for AIDS research
  • Place of Presentation: Hiroshima
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of fusion inhibitors based on resistant mutation against T-20 (2007)
  • Author(s): Izumi K., Kodama E., Shimura K., Oishi S., Fujii N., Matsuoka M.
  • Organizer: 21st Annual meeting of the Japan Society for AIDS research
  • Place of Presentation: Hiroshima
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] HIV activity of T-20 derivatives (2007)
  • Author(s): Shimane K., Izumi K., Kodama E., Oishi S., Fujii N., Matsuoka M.
  • Organizer: 21st Annual meeting of the Japan Society for AIDS research
  • Place of Presentation: Hiroshima
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of novel CXCR4 antagonist having an indole scaffold (2007)
  • Author(s): Katoh M., Ueda S., Inuki S., Oishi S., Ohno H., Evans B., Wang Z., Peiper SC, Fujii N.
  • Organizer: The 26th Symposium on Medicinal Chemistry
  • Place of Presentation: Sagamihara
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and application of Z-alkene and E-fluoroalkene dipeptide isosteres as cis-amide bond equivalents (2007)
  • Author(s): Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
  • Organizer: The 26th Symposium on Medicinal Chemistry
  • Place of Presentation: Sagamihara
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and structure-activity relationship on cystein derivatives having Eg5 inhibiory activity (2007)
  • Author(s): Ogo N., Oishi S., Matsuno K., Sawada J., Fujii N., Asai A.
  • Organizer: The 26th Symposium on Medicinal Chemistry
  • Place of Presentation: Sagamihara
  • Year and Date: 20071128-20071130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ペプチド結合ミメティックスとしてのフルオロアルケン骨格の展望 (2007)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 20071107-20071109
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ヘリックス誘起モチーフを導入した抗HIVペプチドのデザインと合成 (2007)
  • Author(s): 渡辺健太郎, et al.
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 20071107-20071109
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Properties of intracellular fragment peptides of mouse prostaglandin E2 receptor mEP3b isoform (2007)
  • Author(s): Takuya Shinbo, et al.
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 20071107-20071109
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CXCR4受容体アンタゴニストの蛍光標識体の合成と応用 (2007)
  • Author(s): 増田亮, et al.
  • Organizer: 第44回ペプチド討論会
  • Place of Presentation: 富山
  • Year and Date: 20071107-20071109
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Fluoroalkenes for peptidomimetics (2007)
  • Author(s): Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
  • Organizer: 44th Japanese Peptide Symposium
  • Place of Presentation: Toyama
  • Year and Date: 20071107-20071109
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Design and synthesis of anti-HIV peptides having helix-inducible motifs (2007)
  • Author(s): Watanabe K., Itoh S., Nishikawa H., Tanaka M., Oishi S., Ohno H., Izumi K., Kodama E., Matsuoka M., Fujii N.
  • Organizer: 44th Japanese Peptide Symposium
  • Place of Presentation: Toyama
  • Year and Date: 20071107-20071109
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Propertie of intracellular fragment peptides of mouse prostaglandin E2 receptor mEP3b isoform. (2007)
  • Author(s): Shinbo S., Yano Y., Oishi S., Fujii N., Sugimoto Y., Matsuzaki K.
  • Organizer: 44th Japanese Peptide Symposium
  • Place of Presentation: Toyama
  • Year and Date: 20071107-20071109
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and application of fluorescent CXCR4 antagonist (2007)
  • Author(s): Masuda R., Oishi S., Ueda S., Gotoh S., Ohno H., Evans B., Peiper SC, Hirasawa A., Tsujimoto G., Kodama E., Matsuoka M., Fujii N.
  • Organizer: 44th Japanese Peptide Symposium
  • Place of Presentation: Toyama
  • Year and Date: 20071107-20071109
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] パラジウム触媒カルボニル化反応を用いたトリフルオロメチルアルケンジペプチドイソスター及び類縁体の新規合成法の開発 (2007)
  • Author(s): 井ノ口恵利子, et al.
  • Organizer: 第33回反応と合成の進歩シンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 20071105-20071106
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 連続結合形成反応による縮環型芳香族化合物の一挙合成法の開発 (2007)
  • Author(s): 大野浩章, et al.
  • Organizer: 第33回反応と合成の進歩シンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 20071105-20071106
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒を用いたプロパルギルブロミドの連続的閉環反応による二環性複素環の一挙構築 (2007)
  • Author(s): 岡野晃典, et al.
  • Organizer: 第33回反応と合成の進歩シンポジウム
  • Place of Presentation: 長崎
  • Year and Date: 20071105-20071106
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of trifluoroalkene dipeptide isosteres and the related compounds using paradium-catalyzed carbonylation (2007)
  • Author(s): Inokuchi E., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
  • Organizer: The 33rd Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Nagasaki
  • Year and Date: 20071105-20071106
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of synthetic methodology for fused aromatic compounds by consecutive bond formations (2007)
  • Author(s): Ohno H., Ohta Y., Oishi S., Fujii N., Iuchi M., Tanaka T.
  • Organizer: The 33rd Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Nagasaki
  • Year and Date: 20071105-20071106
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of bicyclic heterocycles by paradium-catalyzed domino cyclizations of propargyl bromide (2007)
  • Author(s): Okano A., Ohno H., Fujii N., Kosaka S., Ohhata M., Ishihara K., Tanaka T. Tsukamoto K.
  • Organizer: The 33rd Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Nagasaki
  • Year and Date: 20071105-20071106
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Prediction of drugcytochrome P450 interaction using chemical-biological correlation space model. (2007)
  • Author(s): Teppei Ogawa, Yosuke Minowa, Tetsuya Adachi, Chunlai Fen, Satoshi Niijima, Shinya Oishi, Nobutaka Fujii, Yasushi Okuno
  • Organizer: Annual meeding of CBI society
  • Place of Presentation: Hiroshima
  • Year and Date: 20071003-20071005
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Prediction of drug-cytochrome P450 interaction using chemical-biological correlation space model (2007)
  • Author(s): Teppei Ogawa, et al.
  • Organizer: CBI学会年会
  • Place of Presentation: 広島
  • Year and Date: 20071003-20070305
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis and in vivo evaluation of 18F labeled tluorobenzoyl pentapeptide ([18F]TOM80) as a PET imaging agent for GPR54 (2007)
  • Author(s): T. Fuchigami, et al.
  • Organizer: Seventh Japan-China Joint Semiinar on Radiopharmaceutical Chemistry
  • Place of Presentation: 京都
  • Year and Date: 20070927-20070929
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis and in vivo evaluation of 18F labeled fluorobenzoyl pentapeptide ([18F]TOM80) as a PET imaging agent for GPR54. (2007)
  • Author(s): T. Fuchigami, N. Harada, H. Tsukada, M. Ogawa, H. Yamaguchi, H. Raku, K. Tomita, S. Ohishi, N. Fujii, Y. Magata
  • Organizer: Seventh Japan-China Joint Semiinar on Radiopharmaceutical Chemistry
  • Place of Presentation: Kyoto
  • Year and Date: 20070927-20070929
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 情報から制御へ : ゲノム情報収斂型創薬科学 (2007)
  • Author(s): 藤井信孝
  • Organizer: 21C0E公開シンポジウム
  • Place of Presentation: 京都
  • Year and Date: 20070920-20070921
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] From information to controls : Drug discovery based on genomeinformation (2007)
  • Author(s): Fujii N.
  • Organizer: 21COE symposium
  • Place of Presentation: Kyoto
  • Year and Date: 20070920-20070921
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of novel FIV membrane fusion inhibitors (2007)
  • Author(s): Hiroki Nishikawa, et al.
  • Organizer: Virus Molecular Interactions : Therapeutic Targets
  • Place of Presentation: オックスフォード
  • Year and Date: 20070917-20070919
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Design and synthesis of novel HIV fusion inhibitors (2007)
  • Author(s): Shinya Oishi, et al.
  • Organizer: Virus Molecular Interactions : Therapeutic Targets
  • Place of Presentation: オックスフォード
  • Year and Date: 20070917-20070919
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of novel FIV membrane fusion inhibitors. (2007)
  • Author(s): Nishikawa H., Kodera Y., Oishi S., Tanaka M., Tochikura T., Kajiwara K., Ohno H., Mizukoshi F., Tsujimoto H., Kodama E., Matsuoka M., Fujii N.
  • Organizer: Virus Molecular Interactions : Therapeutic Targets
  • Place of Presentation: Oxford
  • Year and Date: 20070917-20070919
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Design and synthesis of novel HIV fusion inhibitors. (2007)
  • Author(s): Oishi S., Ito S., Nishikawa H., Tanaka M., Ohno H., Otaka A., Izumi K., Kodama E., Matsuoka M., Fujii N.
  • Organizer: Virus Molecular Interactions : Therapeutic Targets
  • Place of Presentation: Oxford
  • Year and Date: 20070917-20070919
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] From amino acids to peptide isosteres : Implication to genome-lead drug discovery (2007)
  • Author(s): Nobutaka Fujii, et al.
  • Organizer: 2nd. World Congress of Pharmacy and Pharmaceutical Sciences
  • Place of Presentation: 北京
  • Year and Date: 20070831-20070906
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] From amino acids to peptide isosteres: Implication to genome-lead drug discovery. (2007)
  • Author(s): Fujii N., Oishi S., Narumi T., Tomita K., Ohno H.
  • Organizer: 2nd. World Congress of Pharmacy and Pharmaceutical Sciences
  • Place of Presentation: Beijing
  • Year and Date: 20070831-20070906
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of GPR54 agonists as anti-metastasis agents (2007)
  • Author(s): 富田健嗣, et al.
  • Organizer: 第八回文部科学省特定領域研究「がん」5領域若手研究者ワークショップ
  • Place of Presentation: 蓼科
  • Year and Date: 20070829-20070901
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of GPR54 agonists as anti-metastasis agents. (2007)
  • Author(s): Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
  • Organizer: The 8th workshop for cancer research for young scientists
  • Place of Presentation: Tateshina
  • Year and Date: 20070829-20070901
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Construction of 2-(aminomethyl) indole motif by Cu-catalyzed multi-component reaction (2007)
  • Author(s): Yusuke Ohta, et al.
  • Organizer: 234th ACS meeting &exposition
  • Place of Presentation: ボストン
  • Year and Date: 20070819-20070823
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres : Lys-Lys and Glu-Glu type FADIs (2007)
  • Author(s): Tetsuo Narumi, et al.
  • Organizer: 234th ACS meeting & exposition
  • Place of Presentation: ボストン
  • Year and Date: 20070819-20070823
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Construction of 2-(aminomethyl)indole motif by Cu-catalyzed multi-component reaction. (2007)
  • Author(s): Ohta Y., Oishi S., Fujii N., Ohno H.
  • Organizer: 234th ACS meeting & exposition
  • Place of Presentation: Boston
  • Year and Date: 20070819-20070823
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Diastereoselective synthesis of functionalized (Z)-fluoroalkene dipeptide isosteres : Lys-Lys and Glu-Glu type FADIs. (2007)
  • Author(s): Narumi T., Kodera Y., Tomita K., Inokuchi E., Oishi S., Ohno H., Fujii N.
  • Organizer: 234th ACS meeting & exposition
  • Place of Presentation: Boston
  • Year and Date: 20070819-20070823
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Construction of 2-(aminome thyl) indole motif by Cu-catalyzed multi-component reaction (2007)
  • Author(s): Yusuke Ohta, et al.
  • Organizer: 14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
  • Place of Presentation: 奈良
  • Year and Date: 20070802-20070806
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation (2007)
  • Author(s): Toshiaki Watanabe, et al.
  • Organizer: 14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
  • Place of Presentation: 奈良
  • Year and Date: 20070802-20070806
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pd-Catalyzed carbonylation of CF3-containing allylic carbonate : applicationto the synthesis of (Z)-trifluoromethylalkene dipeptide isosteres (2007)
  • Author(s): Eriko Inokuchi, et al.
  • Organizer: 14th IUPAC Symposium on Organometallic Chemistry DirectedTowards Organic Synthesis
  • Place of Presentation: 奈良
  • Year and Date: 20070802-20070806
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Construction of 2-(aminomethyl)indole motif by Cu-catalyzed multi-component reaction. (2007)
  • Author(s): Ohta Y., Oishi S., Fujii N., Ohno H.
  • Organizer: 14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
  • Place of Presentation: Nara
  • Year and Date: 20070802-20070806
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and applicatior of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation. (2007)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: 14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
  • Place of Presentation: Nara
  • Year and Date: 20070802-20070806
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pd-Catalyzed carbonylation of CF3-containing allylic carbonate : application to the synthesis of (Z)-trifluoromethylalkene dipeptide isosteres. (2007)
  • Author(s): Inokuchi E., Narumi T., Tomita K., Niida A., Kobayashi K., Oishi S., Ohno H., Fujii N.
  • Organizer: 14th IUPAC Symposium on Organometallic Chemistry Directed Towards Organic Synthesis
  • Place of Presentation: Nara
  • Year and Date: 20070802-20070806
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling (2007)
  • Author(s): Toshiaki Watanabe, et al.
  • Organizer: 6th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: イスタンブール
  • Year and Date: 20070708-20070711
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 98. CXCE4 antagonists : relevance to cancer chemotherapy (2007)
  • Author(s): Kobutaka Fujii
  • Organizer: 6th AFMC IEternational Medicinal Chemistry Symposium
  • Place of Presentation: イスタンブール
  • Year and Date: 20070708-20070711
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] One-pot synthesis of carbazoles by palladium-catalyzed N-arylation and oxidative coupling (2007)
  • Author(s): Watanabe T., Inuki S., Ueda S., Oishi S., Ohno H., Fujii N.
  • Organizer: 6th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Istanbul
  • Year and Date: 20070708-20070711
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] CXCR4 antagonists ; relevance to cancer chemotherapy. (2007)
  • Author(s): Fujii N.
  • Organizer: 6th AFMC International Medicinal Chemistry Symposium
  • Place of Presentation: Istanbul
  • Year and Date: 20070708-20070711
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stereoselective. synthesis of peptidomimetics based on acid-catalyzed ring-opening of・-aziridinyl-・, ・-enoates (2007)
  • Author(s): Hirokazu Tamamura, et al.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: モントリオール
  • Year and Date: 20070626-20070630
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of chemokine receptor CXCR4 antagonists using bio-mimetic strategy (2007)
  • Author(s): Hirokazu Tamamura, et al.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: モントリオール
  • Year and Date: 20070626-20070630
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis and application of (Z)-alkene-and (E)-fluoroalkene-dipeptideisosteres as cis-amide equivalents (2007)
  • Author(s): Kenji Tomita, et al.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: モントリオール
  • Year and Date: 20070626-20070630
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of a novel fusion inhibitor against T-20-resistant HIV-1 (2007)
  • Author(s): Shinya Oishi, et al.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: モントリオール
  • Year and Date: 20070626-20070630
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Stereoselective synthesis of peptidomimetics based on acid-catalyzed ring-opening of □-aziridinyl-□, □-enoates. (2007)
  • Author(s): Tamamura H., Tanaka T., Tsutsumi H., Nemoto K., Mizokami S., Ohashi N., Oishi S., Fujii N.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: Montreal
  • Year and Date: 20070626-20070630
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of chemokine receptor CXCE4 antagonists using bio-mimetic strategy. (2007)
  • Author(s): Tamamura H., Tanaka T., Tsutsumi H., Ohashi N., Hiramatsu K., Araki T., Ojida A., Hamachi I., Wang Z., Peiper SC, Trent JO., Ueda S., Oishi S., Fujii N.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: Montreal
  • Year and Date: 20070626-20070630
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and application of (Z)-alkene- and (E)-fluoroalkene-dipeptide isosteres as cis-amide equivalents. (2007)
  • Author(s): Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: Montreal
  • Year and Date: 20070626-20070630
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of a novel fusion inhibitor against T-20-resistant HIV-1. (2007)
  • Author(s): Oishi S., Ito S., Nishikawa H., Tanaka M., Ohno H., Otaka A., Izumi K., Kodama E., Matsuoka M., Fujii N.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: Montreal
  • Year and Date: 20070626-20070630
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation (2007)
  • Author(s): Toshiaki Watanabe, et al.
  • Organizer: Eighth Tetrahedron Symposium
  • Place of Presentation: ベルリン
  • Year and Date: 20070626-20070629
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis and application of carbazoles by palladium-catalyzed tandem N-arylation and oxidative C-H activation (2007)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: Eighth Tetrahedron Symposium
  • Place of Presentation: Berlin
  • Year and Date: 20070626-20070629
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Pd触媒を用いたタンデム型N-アリール化-C-H活性化によるカルバゾールの合成と反応機構の考察 (2007)
  • Author(s): 渡部敏明, et al.
  • Organizer: 第5回次世代を担う有機化学シンポジウム
  • Place of Presentation: 東京
  • Year and Date: 20070525-20070526
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Palladium-catalyzed synthesis of carbazole by tandem N-arylation and C-H activation. (2007)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: The 5th Symposium on Organic Chemistry - The Next Generation
  • Place of Presentation: Tokyo
  • Year and Date: 20070525-20070526
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 膵臓癌患者における血漿中metastin濃度 (2007)
  • Author(s): 片桐文彦, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
  • Year and Date: 20070509-20070510
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] シスアミド等価体としての(Z)-アルケンおよび(E)-フルオロアルケンジペプチドイソスターの合成とその応用 (2007)
  • Author(s): 富田健嗣, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
  • Year and Date: 20070509-20070510
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] EKコンセプトを利用した高活性HIV膜融合阻害剤の創製研究 (2007)
  • Author(s): 田中理紀, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
  • Year and Date: 20070509-20070510
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ネコ免疫不全ウイルス(FIV)膜融合阻害剤の創製研究 (2007)
  • Author(s): 西川裕樹, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第2回年会
  • Place of Presentation: 京都
  • Year and Date: 20070509-20070510
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Plasma concentration of metastins in pancreatic cancer patients (2007)
  • Author(s): Katagiri F., Nagai K., Kida M., Tomita K., Oishi S., Takeyama M., Doi R., Fujii N.
  • Organizer: 2nd annual meeding of Japan Chemical Biology Society
  • Place of Presentation: Kyoto
  • Year and Date: 20070509-20070510
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and application of (Z)-alkene and (E)-fluoroalkene dipeptide isosteres as cis amide equivalents (2007)
  • Author(s): Tomita K., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
  • Organizer: 2nd annual meeding of Japan Chemical Biology Society
  • Place of Presentation: Kyoto
  • Year and Date: 20070509-20070510
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of Highly potent HIV fusion inhibitors (2007)
  • Author(s): Tanaka M., Itoh S., Oishi S., Nishikawa H., Izumi K., Kodama E., MatsuokE M., Ohno H., Fujii N.
  • Organizer: 2nd annual meeding of Japan Chemical Biology Society
  • Place of Presentation: Kyoto
  • Year and Date: 20070509-20070510
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of fusion inhibitors against feline immunodeficiency virus (FIV) (2007)
  • Author(s): Nishikawa H., Kodera Y., Tanaka M., Mizukoshi F., Tsujimoto H., Kodama E., Matsuoka M., Oishi S., Ohno H., Fujii N.
  • Organizer: 2nd annual meeding of Japan Chemical Biology Society
  • Place of Presentation: Kyoto
  • Year and Date: 20070509-20070510
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] EKコンセプトを利用した高活性HIV膜融合阻害剤の創製研究 (2007)
  • Author(s): 伊藤紗織, et al.
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] GPR54に対するフルオロベンゾイルペンタペプチドの構造親和性相関研究 (2007)
  • Author(s): 富田健嗣, et al.
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Pd触媒を用いたタンデム型N-アリール化-C-H活性化によるカルバゾールの合成と反応機構の考察 (2007)
  • Author(s): 渡部敏明, et al.
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] (Z)-トリフルオロメチルアルケン型ジペプチドイソスターの高立体選択的合成法 (2007)
  • Author(s): 井ノロ恵利子, et al.
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] N-ヘテロサイクリックカルベンによる分子内レドックス反応を利用したフルオロアルケンイソスターの合成 (2007)
  • Author(s): 八巻陽子, et al.
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of highly potent HIV fusion inhibitors by application of EK concept (2007)
  • Author(s): Itoh S., Oishi S., Nishikawa H., Tanaka M., Watanabe K., Izumi K., Kodama E., Matsuoka M., Ohno H., Fujii N.
  • Organizer: The 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-affinity relationship study on fluorobenzoyl pentapeptides for GPR54 (2007)
  • Author(s): Tomita K., Oishi S., Ohno H., Fujii N.
  • Organizer: The 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Palladium-catalyzed synthesis of carbazole by tandem N-arylation and C-H activation. (2007)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: The 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stereoselective synthesi of (Z)-trifluoromethylalkene dipeptide isosteres (2007)
  • Author(s): Inokuchi E., Narumi T., Niida A., Kobayashi K., Oishi S., Ohno H., Fujii N.
  • Organizer: The 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of fluoroalkene isosteres using intramolecular redox reaction by N-heterocyclic carbene (2007)
  • Author(s): Yamaki Y., Shigenaga A., Tomita K., Narumi T., Fujii N., Otaka A.
  • Organizer: The 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama
  • Year and Date: 20070328-20070330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Unprecedented palladium-mediated carbon-fluorine bond cleavage : relevance to the synthesis of fluoroalkene dipeptidomimetics (2007)
  • Author(s): Tetsuo Narumi, et al.
  • Organizer: American Chemical Society 233rd National Meeting & Exposition
  • Place of Presentation: シカゴ
  • Year and Date: 20070325-20070329
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Unprecedented palladium- mediated carbon-fluorine bond cleavage : relevance to the synthesis of fluoroalkene dipeptidomimetics. (2007)
  • Author(s): Narumi T., Inokuchi E., Tomita K, Oishi S., Ohno H., Fujii N.
  • Organizer: American Chemical Society 233rd National Meeting & Exposition
  • Place of Presentation: Chicago
  • Year and Date: 20070325-20070329
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] structure-activity relationship study on GPR54 agonist as novel anti-metastatic agent (2007)
  • Author(s): Kenji Tomita, et al.
  • Organizer: First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
  • Place of Presentation: 名古屋
  • Year and Date: 20070312-20070314
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of cyclic pentapeptide-based CXCR4 antagonists for the treatment of CXCR4-mediated diseases (2007)
  • Author(s): Satoshi Ueda, et al.
  • Organizer: First JGA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
  • Place of Presentation: 名古屋
  • Year and Date: 20070312-20070314
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CXCR4 antagonists : Relevance to small cell lung cancer chemotherapy. (2007)
  • Author(s): Nobutaka Fujii, et al.
  • Organizer: First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
  • Place of Presentation: 名古屋
  • Year and Date: 20070312-20070314
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structure-activity relationship study on GPR54 agonist as novel anti-metastatic agent. (2007)
  • Author(s): Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
  • Organizer: First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
  • Place of Presentation: Nagoya
  • Year and Date: 20070312-20070314
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of cyclic pentapeptide- based CXCR4 antagonists for the treatment of CXCR4-mediated diseases. (2007)
  • Author(s): Ueda S., Oishi S., Wang Z., Ohno H., Peiper SC, Fujii N.
  • Organizer: First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
  • Place of Presentation: Nagoya
  • Year and Date: 20070312-20070314
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] CXCR4 antagonists : Relevance to small cell lung cancer chemotherapy. (2007)
  • Author(s): Fujii N., Oishi S., Ueda S.
  • Organizer: First JCA-AACR Special Joint Conference : The Latest Advances in Lung Cancer Research : From Basic Science to Therapeutics
  • Place of Presentation: Nagoya
  • Year and Date: 20070312-20070314
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] From knowledge to controlling : implications of peptide-lead drug templates for genome-lead discovery (2007)
  • Author(s): Nobutaka Fujii, et al.
  • Organizer: RIKEN International Symposium on Chemical Biology
  • Place of Presentation: 箱根
  • Year and Date: 20070111-20070113
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] From knowledge to controlling : implications of peptide-lead drug templates for genome-lead discovery. (2007)
  • Author(s): Nobutaka Fujii, Hiroaki Ohno, Shinya Oishi
  • Organizer: RIKEN International Symposium on Chemical Biology
  • Place of Presentation: Hakone
  • Year and Date: 20070111-20070113
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築 (2007)
  • Author(s): 井貫晋輔, et al.
  • Organizer: 第27回有機合成若手セミナー
  • Place of Presentation: 京都
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒カルボニル化反応を用いたトリフルオロメチルアルケンジペプチドイソスター及び類縁体の新規合成法の開発 (2007)
  • Author(s): 井ノ口恵利子, et al.
  • Organizer: 第27回有機合成若手セミナー
  • Place of Presentation: 京都
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of ergot alkaloids by paradium-catalyzed domino cyclizations of allenes (2007)
  • Author(s): Inuki S., Oishi S., Fuji N., Ohno H.
  • Organizer: 27th Seminars on Organic Synthesis for Young Scientists
  • Place of Presentation: Kyoto
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of trifluoroalkene dipeptide isosteres and the related compounds using paradium-catalyzed carbonylation (2007)
  • Author(s): Inokuchi E., Narumi T., Niida A., Tomita K, Oishi S., Ohno H., Fujii N.
  • Organizer: 27th Seminars on Organic Synthesis for Young Scientists
  • Place of Presentation: Kyoto
  • Year and Date: 2007-11-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 有機金属による炭素-フツ素結合切断を伴うフルオロアルケン骨格の合成 : 多価官能基を有するフルオロアルケン型ジベブチドイソスターの高立体選択的合成への展開 (2007)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 第57回日本薬学会近畿支部大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒を用いたアレンの連続環化反応によるErgot Alkaloid骨格の一挙構築 (2007)
  • Author(s): 井貫晋輔, et al.
  • Organizer: 第57回日本薬学会近畿支部大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒によるカルボニル化反応を用いたトリフルオロメチルアルケン型ジペプチドイソスター及び類縁体の新規合成法の開発 (2007)
  • Author(s): 井ノ口恵利子, et al.
  • Organizer: 第57回日本薬学会近畿支部大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] インドールを母核とした新規ケモカインレセプターCXCR4アンタゴニストの創製研究 (2007)
  • Author(s): 加藤学, et al.
  • Organizer: 第57回日本薬学会近畿支部大会
  • Place of Presentation: 大阪
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of fluoroalkenes of organometal-mediated C-F bond cleavage : application of stereoselective synthesis of multifunctionalized fluoroalkene dipeptide isosteres (2007)
  • Author(s): Narumi T., Tomita K., Inokuchi E., Kobayashi K., Oishi S., Ohno H., Fujii N.
  • Organizer: The 57th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Osaka
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of ergot alkaloids by paradium-catalyzed domino cyclizations of allenes (2007)
  • Author(s): Inuki S., Oishi S., Fuji N., Ohno H.
  • Organizer: The 57th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Osaka
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of synthetic method for trifluoromethylalkene dipeptide isosteres by paradium-catalyzed carbonylation (2007)
  • Author(s): Inokuchi E., Narumi T., Niida A., Oishi S., Ohno H., Fujii N.
  • Organizer: The 57th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Osaka
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of novel CXCR4 antagonist having an indole scaffold (2007)
  • Author(s): Katoh M., Ueda S., Inuki S., Oishi S., Ohno H., Fujii N.
  • Organizer: The 57th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Osaka
  • Year and Date: 2007-10-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] シスアミド等価型アルケンジベプチドイソスターの合成と応用 (2006)
  • Author(s): 大石真也, et al.
  • Organizer: 第32回反応と合成の進歩シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 20061204-20061205
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒による炭素-フッ素結合切断を伴うフルオロアルケン骨格の合成 (2006)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 第32回反応と合成の進歩シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 20061204-20061205
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 銅触媒を用いた三成分カップリングによる2-(アミノメチル)インドール骨格構築法の開発 (2006)
  • Author(s): 太田悠介, et al.
  • Organizer: 第32回反応と合成の進歩シンポジウム
  • Place of Presentation: 広島
  • Year and Date: 20061204-20061205
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesi and application of cis-amide equivalent alkene dipeptide isosteres (2006)
  • Author(s): Oishi S., Niida A., Narumi T., Tomita K., Inokuchi E., Ohno H., Kitaura K., Fujii N., Otaka A., Inui K.
  • Organizer: The 32th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Hiroshima
  • Year and Date: 20061204-20061205
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of fluoroalkenes by paradium-catalyzed C-F bond cleavage (2006)
  • Author(s): Narumi T., Tomita K., Inokuchi E., Oishi S., Ohno H., Fujii N.
  • Organizer: The 32th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Hiroshima
  • Year and Date: 20061204-20061205
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of 2-(aminomethyl)indoles by organocopper-mediated three-component coupling (2006)
  • Author(s): Ohta Y., Oishi S., Fujii N.. Ohno H.
  • Organizer: The 32th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Hiroshima
  • Year and Date: 20061204-20061205
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] EKコンセプトを利用した高活性HIV膜融合阻害剤の創製研究 (2006)
  • Author(s): 伊藤紗織, et al.
  • Organizer: 第25回メディシナルケミストリーシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 20061129-20061201
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 二核亜鉛錯体構造を有する新規ケモカインレセプターCXCR4アンタゴニストの創製 (2006)
  • Author(s): 小川哲平, et al.
  • Organizer: 第25回メディシナルケミストリーシンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 20061129-20061201
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of highly potent HIV fusion inhibitors based on EK-concept (2006)
  • Author(s): Itoh S., Oishi S., Nishikawa H., Tanaka M., Izumi K., Kodama E., Matsuoki M., Ohno H., Fujii N.
  • Organizer: The 25th Symposium on Medicinal Chemistry
  • Place of Presentation: Nagoya
  • Year and Date: 20061129-20061201
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of novel CXCR4 antagonists having bivalent Zn-complexes (2006)
  • Author(s): Ogawa T., Tamamura H., Ojida A., Tsutsumi H., Nakajima H., Oishi S., Ohno H., Hamachi I., Fujii N.
  • Organizer: The 25th Symposium on Medicinal Chemistry
  • Place of Presentation: Nagoya
  • Year and Date: 20061129-20061201
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] structure-activity relationship studies on N-terminal acyl groups ofpentapeptidic GPR54 agonists (2006)
  • Author(s): Kenii Tomita, et al.
  • Organizer: The 3rd Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
  • Place of Presentation: ソウル
  • Year and Date: 20061126-20061128
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] New peptide design for HIV-1 fusion inhibitors against T-20-resistant HIV-1variants (2006)
  • Author(s): Hiroki Nishikawa, et al.
  • Organizer: The 3rd Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
  • Place of Presentation: ソウル
  • Year and Date: 20061126-20061128
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structure-activity relationship studies on N-terminal acyl groups of pentapeptidic GPR54 agonists. (2006)
  • Author(s): Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
  • Organizer: The 3rd Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
  • Place of Presentation: Seoul
  • Year and Date: 20061126-20061128
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] New peptide design for HIV-1 fusion inhibitors against T-20resistant HIV-1 variants. (2006)
  • Author(s): Nishikawa H., Kodama E., Ito S., Kajiwara K., Izumi K., Oishi S., Matsuoka M., Fujii N.
  • Organizer: The 3rd Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists
  • Place of Presentation: Seoul
  • Year and Date: 20061126-20061128
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] GPR54アゴニストの構造活性相関研究 (2006)
  • Author(s): 富田健嗣, et al.
  • Organizer: 第34回構造活性相関シンポジウム
  • Place of Presentation: 新潟
  • Year and Date: 20061114-20061115
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structure-activity relationship study on GPR54 agonists (2006)
  • Author(s): Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
  • Organizer: The 34th Symposium on Structure-Activity Relationships
  • Place of Presentation: Niigata
  • Year and Date: 20061114-20061115
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Allylic hydrodefluorination under palladium catalysis for the synthesis offluoroalkene dipeptide isosteres (2006)
  • Author(s): Tetsuo Narumi, et al.
  • Organizer: The 10th International KYOTO Conference on New Aspects of Organic Chemistry
  • Place of Presentation: 京都
  • Year and Date: 20061113-20061117
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Palladium-catalyzed synthesis of carbazole by tandem N-arylation and C-H activation (2006)
  • Author(s): Toshiaki Watanabe, et al.
  • Organizer: The 10th International KYOTO Conference on New Aspects of Organic Chemistry
  • Place of Presentation: 京都
  • Year and Date: 20061113-20061117
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Allylic hydrodefluorination under palladium catalysis for the synthesis of fluoroalkene dipeptide isosteres. (2006)
  • Author(s): Narumi T., Tomita K., Inokuchi E., Oishi S., Ohno H., Fujii H.
  • Organizer: The 10th International KYOTO Conference on New Aspects of Organic Chemistry
  • Place of Presentation: Kyoto
  • Year and Date: 20061113-20061117
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Palladium-catalyzed synthesis of carbazole by tandem N-arylation and C-H activation. (2006)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: The 10th International KYOTO Conference on New Aspects of Organic Chemistry
  • Place of Presentation: Kyoto
  • Year and Date: 20061113-20061117
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] From amino acids to peptide isosteres : Implication to genome-lead drug discovery (2006)
  • Author(s): Nobutaka Fujii, et al.
  • Organizer: 2nd Intermational Symposium on Biomolecules and Related Compounds
  • Place of Presentation: 京都
  • Year and Date: 20061110-20061112
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] From amino acids to peptide isosteres : Implication to genome-lead drug discovery. (2006)
  • Author(s): Fujii N.
  • Organizer: 2nd Intermational Symposium on Biomolecules and Related Compounds
  • Place of Presentation: Kyoto
  • Year and Date: 20061110-20061112
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] structure-activity relationship studies on GPR54 agonists (2006)
  • Author(s): Kenii Tomita, et al.
  • Organizer: The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
  • Place of Presentation: 横浜
  • Year and Date: 20061105-20061108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A novel oxazolidine linker for the synthesis of peptide aldehydes (2006)
  • Author(s): Michinori Tanaka, et al.
  • Organizer: The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
  • Place of Presentation: 横浜
  • Year and Date: 20061105-20061108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Establishment and clinical application of an enzyme immunoassay for metastin to determination of the human plasma levels (2006)
  • Author(s): Fumihiko Katagiri, et al.
  • Organizer: The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
  • Place of Presentation: 横浜
  • Year and Date: 20061105-20061108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of chemical probes for the chemokine receptor CXCR4 involving radiolabeled T140 anglogs (2006)
  • Author(s): Hirokazu Tamamura, et al.
  • Organizer: The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
  • Place of Presentation: 横浜
  • Year and Date: 20061105-20061108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structure-activity relationship studies on GPR54 agonists (2006)
  • Author(s): Tomita K., Oishi S., Ohno H., Akamatsu M., Fujii N.
  • Organizer: The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 20061105-20061108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A novel oxazolidine linker for the synthesis of peptide aldehydes. (2006)
  • Author(s): Tanaka M., Oishi S., Ohno H., Fujii N.
  • Organizer: The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 20061105-20061108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Establishment anc clinical application of an enzyme immunoassay for metastin to determination of the human plasma levels. (2006)
  • Author(s): Katagiri F., Tomita K., Oishi S., Takeyama M., Fujii N.
  • Organizer: The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 20061105-20061108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of chemical probes for the chemokine receptor CXCR4 involving radiolabeled T140 anglogs. (2006)
  • Author(s): Tamamura H., Hanaoka H., Tsutsumi H., Ohashi N., Tanaka T., Mori T., Mukai T., Doi R., Saji H., Fujii N.
  • Organizer: The International Conference of 43rd Japanese Peptide Symposium and 4th Peptide Engineering Meeting
  • Place of Presentation: Yokohama
  • Year and Date: 20061105-20061108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] パラジウム触媒を用いたタンデム型N-アリール化-C-H活性化によるカルバゾールの合成 (2006)
  • Author(s): 渡部敏明, et al.
  • Organizer: 第23回有機合成化学セミナー
  • Place of Presentation: 大沼
  • Year and Date: 20060913-20060915
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of carbazoles by paradium-catalyzed tandem N-arylation and C-H activation (2006)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: The 23rd Seminars on Organic Chemistry
  • Place of Presentation: Onuma
  • Year and Date: 20060913-20060915
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] From ami no acids to peptide isosteres and heterocycles : implications to vinylaziri- dines and amiho allene chemistry (2006)
  • Author(s): Hiroaki Ohno, et al.
  • Organizer: 11th Akabori conference
  • Place of Presentation: レーゲンスブルク
  • Year and Date: 20060911-20060912
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] From amino acids to peptide isosteres and heterocycles : implications to vinylaziri- dines and amino allene chemistry. (2006)
  • Author(s): Hiroaki Ohno, Tetsuaki Tanaka, Nobutaka Fujii
  • Organizer: 11th Akabori conference
  • Place of Presentation: Regensburg
  • Year and Date: 20060911-20060912
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] structure-activity relationship studies on cyclic peptide-based CXCR4 antagonists : Side-chain and backbone modifications (2006)
  • Author(s): Satoshi Ueda, et al.
  • Organizer: 232nd American Chemical Society National Meeting & Exposition
  • Place of Presentation: サンフランシスコ
  • Year and Date: 20060910-20060914
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] From amino acids to peptide isosteres : Implications to peptide-lead drugtemplates for genome-lead drug discovery (2006)
  • Author(s): Nobutaka Fujii, et al.
  • Organizer: 232nd American Chemical Society National Meeting & Exposition
  • Place of Presentation: サンフランシスコ
  • Year and Date: 20060910-20060914
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structure-activity relationship studies on cyclic peptide-based CXCR4 antagonists : Side-chain and backbone modifications. (2006)
  • Author(s): Satoshi Ueda, Shinya Oishi, Zixuan Wang, Hiroaki Ohno, Stephen C. Peiper, Nobutaka Fujii
  • Organizer: 232nd American Chemical Society National Meeting & Exposition
  • Place of Presentation: San Francisco
  • Year and Date: 20060910-20060914
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] From amino acids to peptide isosteres : Implications to peptide-lead drug templates for genome-lead drug discovery. (2006)
  • Author(s): Nobutaka Fujii, Shinya Oishi, Tetsuo Narumi, Kenji Tomita, Hiroaki Ohno
  • Organizer: 232nd American Chemical Society National Meeting & Exposition
  • Place of Presentation: San Francisco
  • Year and Date: 20060910-20060914
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] パラジウム触媒を用いたタンデム型N-アリール化-C-H活性化によるカルバゾールの一挙合成 (2006)
  • Author(s): 渡部敏明, et al.
  • Organizer: 第7回長井長義記念シンポジウム
  • Place of Presentation: 徳島
  • Year and Date: 20060906-20060907
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 46. Oxazolidine Linker を用いたペプチドアルデヒドの固相合成 (2006)
  • Author(s): 田中理紀, et al.
  • Organizer: 第7回長井長義記念シンポジウム
  • Place of Presentation: 徳島
  • Year and Date: 20060906-20060907
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 情報から制御へ (2006)
  • Author(s): 藤井信孝
  • Organizer: 第7回長井長義記念シンポジウム
  • Place of Presentation: 徳島
  • Year and Date: 20060906-20060907
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] One-pot synthesis of carbazoles using paradium-catalyzed tandem N-arylation and C-H activation (2006)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: The 7th Nagai Nagayoshi Memorial Symposium
  • Place of Presentation: Tokushima
  • Year and Date: 20060906-20060907
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Solid-phase synthesis of peptide aldehydes using an oxazolidine linker (2006)
  • Author(s): Tanaka M., Oishi S., Ohno H., Fujii N.
  • Organizer: The 7th Nagai Nagayoshi Memorial Symposium
  • Place of Presentation: Tokushima
  • Year and Date: 20060906-20060907
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] From information to controls (2006)
  • Author(s): Fujii N.
  • Organizer: The 7th Nagai Nagayoshi Memorial Symposium
  • Place of Presentation: Tokushima
  • Year and Date: 20060906-20060907
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regio-and stereoselective synthesis of (Z)-alkene CiS-Xaa-Pro dipeptidemimetics with organocopper-mediated anti-SN2' reactions (2006)
  • Author(s): Yoshikazu Sasaki, et al.
  • Organizer: 29th European Peptide Symposium
  • Place of Presentation: グダンスク
  • Year and Date: 20060903-20060908
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Diastereoselective synthesis of (Z)-fluoroalkene dipeptide isosteres based on organocopper-mediated reduction/direct alkylation via transmetalation (2006)
  • Author(s): Tetsuo Narumi, et al.
  • Organizer: 29th European Peptide Symposium
  • Place of Presentation: グダンスク
  • Year and Date: 20060903-20060908
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Discovery of novel low-molecular-weight GPR54 agonists (2006)
  • Author(s): Ryuichiro Doi, et al.
  • Organizer: 29th European Peptide Symposium
  • Place of Presentation: グダンスク
  • Year and Date: 20060903-20060908
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Kegio- and stereoselective synthesis of (Z)-alkene cis-Xaa-Pro dipeptide mimetics with organocopper- mediated anti-SN2' (2006)
  • Author(s): Yoshikazu Sasaki, Takashi Tsuji, Ayumu Niida, Akira Shigenaga, Nobutaka Fujii, Akira Otaka
  • Organizer: 29th European Peptide Symposium
  • Place of Presentation: Gdansk
  • Year and Date: 20060903-20060908
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Diastereoselective synthesis of (Z)-fluoroalkene dipeptide isosteres based on organocopper-mediated reduction/direct alkylation via transmetalation. (2006)
  • Author(s): Tetsuo Narumi, Kenji Tomita, Ayumu Niida, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii
  • Organizer: 29th European Peptide Symposium
  • Place of Presentation: Gdansk
  • Year and Date: 20060903-20060908
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Discovery of novel low-molecular-weight GPR54 agonists. (2006)
  • Author(s): Shinya Oishi, Kenji Tomita, Ayumu Niida, Miki Akamatsu, Toshihiko Masui, Ryuichiro Doi, Jean-Marc Navenot, Zixang Wang, Stephen C. Peiper, Nobutaka Fujii
  • Organizer: 29th European Peptide Symposium
  • Place of Presentation: Gdansk
  • Year and Date: 20060903-20060908
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] structure-activity relationship studies on cyclic peptide-based CXCR4 antagonists (2006)
  • Author(s): Satoshi Ueda, et al.
  • Organizer: ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
  • Place of Presentation: 京都
  • Year and Date: 20060723-20060728
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] structure-activity relation- ship study on GPR54 agonists (2006)
  • Author(s): Kenji Tomita, et al.
  • Organizer: ICOB-5 & ISCKP-25 IUPAC InternatiBiodiversity and Natural onal Conference on Products
  • Place of Presentation: 京都
  • Year and Date: 20060723-20060728
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of synthetic methodology toward (Z)-fluoro- alkene dipeptideisosteres based on the concept of organometalic-mediated C-F bond cleavage (2006)
  • Author(s): Tetsuo Narumi, et al.
  • Organizer: ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Katiural Products
  • Place of Presentation: 京都
  • Year and Date: 20060723-20060728
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structure-activity relationship studies on cyclic peptide-based CXCK4 antagonists. (2006)
  • Author(s): eda S., Oishi S., Wang Z., Araki T., Tamamura H., Ohno H., NakashimaH., Peiper SC, Fujii N.
  • Organizer: ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
  • Place of Presentation: Kyoto
  • Year and Date: 20060723-20060728
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structureactivity relationship study on GPR54 agonists. (2006)
  • Author(s): Tomita K., Niida A., Oishi S., Ohno H., Akamatsu M., Fujii N.
  • Organizer: ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
  • Place of Presentation: Kyoto
  • Year and Date: 20060723-20060728
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of synthetic methodology toward (Z)-fluoro- alkene dipeptide isosteres based on the concept of organometalic-mediated C-F bond cleavage. (2006)
  • Author(s): Tetsuo Narumi, Kenji Tomita, Ayumu Niida, Yasuyo Kodera, Shinya Oishi, Hiroaki Ohno, Nobutaka Fujii
  • Organizer: ICOB-5 & ISCNP-25 IUPAC International Conference on Biodiversity and Natural Products
  • Place of Presentation: Kyoto
  • Year and Date: 20060723-20060728
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] (Z)-トリフルオロメチルアルケン型ジベプチドイソスターの高立体選択的合成法の確立と生理活性ペプチドへの応用 (2006)
  • Author(s): 井ノロ恵利子, et al.
  • Organizer: 第41回天然物談話会
  • Place of Presentation: 北海道
  • Year and Date: 20060703-20060705
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Stereselective synthesi of (Z)-trifluororhethyl alkene dipeptide isosteres and the application to bioactive peptides (2006)
  • Author(s): Inokuchi E., Narumi T., Niida A., Tomita K., Oishi S., Ohno H., Fujii N.
  • Organizer: The 41th Seminars on Natural Products
  • Place of Presentation: Hokkaido
  • Year and Date: 20060703-20060705
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 有機金属による炭素-フツ素結合切断を伴うフルオロアルケン骨格の合成 : 多価官能基を有するフルオロアルケン型ジペブチドイソスターの高立体選択的合成への展開 (2006)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 第4回次世代を担う有機化学シンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 20060519-20060520
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of fluoroalkenes by organometal-mediated C-F bond cleavage : Application to highly functionalized fluoroalkene dipeptide isosteres (2006)
  • Author(s): Narumi T., Tomita K., Niida A., Oishi S., Otaka A., Ohno H., Fujii N.
  • Organizer: The 4th Symposium on Organic Chemistry - The Next Generation -
  • Place of Presentation: Osaka
  • Year and Date: 20060519-20060520
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Preparation of peptide thioester utilizing S-protected oxazolidinonederived from cysteine. (2006)
  • Author(s): Akira Otaka, et al.
  • Organizer: The 11th Korea-Japan Joint Symposium on Drug Design and Development
  • Place of Presentation: 済州島
  • Year and Date: 20060510-20060512
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of (Z)-alkene-containing Pro dipeptide isosteres corresponding tocis-prolyl peptides. (2006)
  • Author(s): Yoshikazu Sasaki, et al.
  • Organizer: The 11th Korea-Japan Joint Symposium on Drug Design and Development
  • Place of Presentation: 済州島
  • Year and Date: 20060510-20060512
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] From genome to lead : medicinal chemistry beyond XXX-omics researches. (2006)
  • Author(s): Kobutaka Fujii
  • Organizer: The 11th Korea-Japan Joint Symposium on Drug Design and Development
  • Place of Presentation: 済州島
  • Year and Date: 20060510-20060512
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Preparation of peptide thioester utilizing S-protected oxazolidinone derived from cysteine. (2006)
  • Author(s): Otaka A., Ohta Y., Shigenaga A., Fujii N.
  • Organizer: The 1lth Korea-Japan Joint Symposium on Drug Design and Development
  • Place of Presentation: Cheju
  • Year and Date: 20060510-20060512
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of (Z)-alkene-containing Pro dipeptide isosteres corresponding to cis-prolyl peptides (2006)
  • Author(s): Sasaki Y., Niida A., Tsuji T., Shigenaga A., Fujii N., Otaka A.
  • Organizer: The 1lth Korea-Japan Joint Symposium on Drug Design and Development
  • Place of Presentation: Cheju
  • Year and Date: 20060510-20060512
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] From genome to lead : medicinal chemistry beyond XXX-omics researches. (2006)
  • Author(s): Fujii, N.
  • Organizer: The 1lth Korea-Japan Joint Symposium on Drug Design and Development
  • Place of Presentation: Cheju
  • Year and Date: 20060510-20060512
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 4-(dimethylamino)phenaoyl基を基盤とした光感受性保護基の開発とペプチド合成への応用 (2006)
  • Author(s): 上田聡, et al.
  • Organizer: 日本ケミカルバイオロジー研究会第一回年会
  • Place of Presentation: 東京
  • Year and Date: 20060508-20060509
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of a novel photo-labile protecting group having 4(dimethylamino)phenacyl group and the application to peptide synthesis (2006)
  • Author(s): Ueda S., Tomita K., Nomura M., Otaka A., Oishi S., Ohno H., Fujii N.
  • Organizer: 1st Annual Meeting of Japan Chemical Biology Society
  • Place of Presentation: Tokyo
  • Year and Date: 20060508-20060509
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 有機金属試薬を利用した位置及び立体選択的CiS-アミノ酸-プロリン型(Z)アルケンジペプチドイソスター合成 (2006)
  • Author(s): 佐々木義一, et al.
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] フルオロアルケンイソスターの高立体選択的合成法の開発と生理活性ペプチドへの応用 (2006)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒による炭素-フツ素結合活性化を伴うフルオロアルケンイソスターの新規合成法の開発 (2006)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規光感受性保護基の開発と応用(1) : 4-(dimethylamino)phenacyl基を基盤とした光感受性カルボキシル及びアミノ保護基の開発 (2006)
  • Author(s): 上田聡, et al.
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規光感受性保護基の開発と応用(2) : 膜蛋白質の化学合成を指向したペプチドフラグメントのone-pot連続縮合反応 (2006)
  • Author(s): 小川哲平, et al.
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低分子非ペプチド性CXCE4アンタゴニストの創製研究 (2006)
  • Author(s): 玉村啓和, et al.
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 新規環状母各構造を有するCXCR4アンタゴニストの合成および構造活性相関研究 (2006)
  • Author(s): 渡部敏明, et al.
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] ペンタペプチド性GPR54アゴニストのN末端領域における構造活性相関研究および定量的構造活性相関研究 (2006)
  • Author(s): 富田健嗣, et al.
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 7回膜貫通GPCRを分子標的とする創薬基盤の革新を目指して (2006)
  • Author(s): 藤井信孝
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Regio- and stereo-selective cis-Xaa-Pro-type (Z)-alkene dipeptide isosteres using organometal reagents (2006)
  • Author(s): Sasaki Y., Tsuji T., Niida A., Fujii N., Otaka A.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Highly stereoselective synthesis of fluoroalkene isosteres and the application to bioactive peptides (2006)
  • Author(s): Narumi T., Miyatani T., Niida A., Tomita K., Oishi S., Otaka H., Ohno H., Fujii N.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Novel synthesis of fluoroalkene isosteres utilizing paradium-catalyzed cleavage of C-F bond activation (2006)
  • Author(s): Narumi T., Niida A., Tomita K., Oishi S., Otaka A., Ohno H., Fujii N.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development and application of novel photo-labile protecting groups (1) : 4(dimethylamino)phenacyl protecting groups for carboxy- and amino-groups group (2006)
  • Author(s): Ueda S., Nomura M., Ogawa T., Otaka A., Fujii N.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development and application of novel photo-labile protecting groups (2) : One-pot coupling reactions of peptide fragments for chemical synthesis of membrane proteins (2006)
  • Author(s): Ogawa T., Ueda S., Tomita K, Otaka A., Fujii N.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of small-molecule CXCR4 antagonists (2006)
  • Author(s): Tamamura H., Mizogami T., Hiramatsu K., Ogawa T., Ueda S., Tsutsumi H., Masuno H., Yamamoto N., Fujii N.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-activity relationship study on novel CXCR4 antagonists having a cyclic scaffold (2006)
  • Author(s): Watanabe T., Esaka R., Ogawa T., Ueda S., Tamamura H., Oishi S., Trent, JO., Wang, Z., Peiper, SC. Fujii N.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] SAR and QSAR studies on N-terminal moieties of pentapeptide GPR54 agonists (2006)
  • Author(s): Tomita K., Niida A., Harada T., Oishi S., Ohno H., Akamatsu M., Fujii N.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Drag discovery targeting for 7TM-GPCRs (2006)
  • Author(s): Fujii N.
  • Organizer: The 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai
  • Year and Date: 20060328-20060330
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 銅触媒を用いた三成分カップリングによる2-(アミノメチル)インドール骨格構築法の開発 (2006)
  • Author(s): 太田悠介, et al.
  • Organizer: 第26回有機合成若手セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2006-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒による炭素-フッ素結合切断を伴うフルオロアルケン骨格の合成 (2006)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 第26回有機合成若手セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2006-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒を用いたタンデム型N-アリール化-C-H活性化によるカルバゾールの一挙合成 (2006)
  • Author(s): 渡部敏明, et al.
  • Organizer: 第26回有機合成若手セミナー
  • Place of Presentation: 大阪
  • Year and Date: 2006-12-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of 2-(aminomethyl)indoles by organocopper-mediated three-component coupling (2006)
  • Author(s): Ohta Y., Oishi S., Fujii N., Ohno H.
  • Organizer: 26th Seminar on Organic Synthesis for Young Scientists
  • Place of Presentation: Osaka
  • Year and Date: 2006-12-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of fluoroalkenes by paradium-catalyzed C-F bond cleavage (2006)
  • Author(s): Narumi T., Tomita K., Inokuchi E., Oishi S., Ohno H., Fujii N.
  • Organizer: 26th Seminar on Organic Synthesis for Young Scientists
  • Place of Presentation: Osaka
  • Year and Date: 2006-12-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Palladium-catalyzed synthesis of carbazole by tandem N-arylation and C-H activation. (2006)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: 26th Seminar on Organic Synthesis for Young Scientists
  • Place of Presentation: Osaka
  • Year and Date: 2006-12-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] GPCR創薬 : 情報から制御へ (2006)
  • Author(s): 藤井信孝
  • Organizer: 第269回CBI研究会講演会
  • Place of Presentation: 東京
  • Year and Date: 2006-11-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Drug Discovery for GPCR: From information to controls (2006)
  • Author(s): Fujii N.
  • Organizer: The 269th Symposium of CBI society
  • Place of Presentation: Tokyo
  • Year and Date: 2006-11-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] HIV T20耐性株に対する新規抗ウイルス剤の創製研究 (2006)
  • Author(s): 伊藤紗織, et al
  • Organizer: 第56回日本薬学会近畿支部大会
  • Place of Presentation: 京都
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 銅触媒を用いた三成分カップリングによる2-(アミノメチル)インドール骨格の構築 (2006)
  • Author(s): 太田悠介, et al.
  • Organizer: 第56回日本薬学会近畿支部大会
  • Place of Presentation: 京都
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 二核亜鉛錯体構造を有するケモカインレセプターCXCR4の新規アンタゴニストの創製 (2006)
  • Author(s): 小川哲平, et al.
  • Organizer: 第56回日本薬学会近畿支部大会
  • Place of Presentation: 京都
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 膜融合阻害活性を有する抗FIV剤の創製研究 (2006)
  • Author(s): 小寺泰代, et al.
  • Organizer: 第56回日本薬学会近畿支部大会
  • Place of Presentation: 京都
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] パラジウム触媒を用いたタンデム型K-アリール化、C-H活性化によるカルバゾールの合成 (2006)
  • Author(s): 渡部敏明, et al.
  • Organizer: 第56回日本薬学会近畿支部大会
  • Place of Presentation: 京都
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of novel antiviral agents against T-20 registant HIV (2006)
  • Author(s): Itoh S., Oishi S., Nishikawa H., Tanaka M., Izumi K., Kodama E., Matsuoka M., Ohno H., Fujii N.
  • Organizer: The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Kyoto
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of 2-(aminomethyl)indoles by organocopper-catalyzed three-component coupling (2006)
  • Author(s): Ohta Y., Oishi S., Fujii N., Ohno H.
  • Organizer: The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Kyoto
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of chemokine receptor CXCR4 antagonists having bivalent Zn-complex structure (2006)
  • Author(s): Ogawa T., Tamamura H., Ojida A., Tsutsumi H., Masuno H., Nakajima H., Yamamoto N., Oishi S., Ohno H., Hamachi I., Fujii N.
  • Organizer: The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Kyoto
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of anti-FIV agents having fusion inhibitory activiry (2006)
  • Author(s): Kodera Y., Nishikawa H., Tanaka M., Mizukoshi F., Tsujimoto H., Kodama E., Matsuoka M., Oishi S., Ohno H., Fujii N.
  • Organizer: The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Kyoto
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesi of calbazoles by paradium-mediated tandem N-arylation and C-H activation (2006)
  • Author(s): Watanabe T., Ueda S., Oishi S., Fujii N., Ohno H.
  • Organizer: The 56th Kinki Regional Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Kyoto
  • Year and Date: 2006-10-28
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ケミカルバイオロジーを指向した4-(dimethylamino)phenacyl型新規光感受性保護基の開発 (2006)
  • Author(s): 小川哲平, et al.
  • Organizer: バイオメディカル研究会
  • Place of Presentation: 大阪
  • Year and Date: 2006-09-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of novel photo-labile 4-(dimethylamino)phenacyl-type protecting groups for chemical biology (2006)
  • Author(s): Ogawa T., Ueda S., Nomura M., Otaka A., Oishi S., Ohno H., Fujii N.
  • Organizer: Seminars on Biomedical Researches
  • Place of Presentation: Osaka
  • Year and Date: 2006-09-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] カルボキシル及びアミノ基への新規光感受性保護基の開発 (2006)
  • Author(s): 小川哲平, et al.
  • Organizer: 第33回有機反応懇談会
  • Place of Presentation: 京田辺
  • Year and Date: 2006-08-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] (Z)-トリフルオロメチルアルケン型ジベプチドイソスターの高立体選択的合成法の確立と生理活性ペプチドへの応用 (2006)
  • Author(s): 井ノロ恵利子, et al.
  • Organizer: 第33回有機反応懇談会
  • Place of Presentation: 京田辺
  • Year and Date: 2006-08-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of novel photolabile protecting groups for carboxyl- and amino-groups (2006)
  • Author(s): Ogawa T., Ueda S., Oishi S., Ohno H., Fujii N.
  • Organizer: 33rd Seminars on Organic Reactions
  • Place of Presentation: Kyotanabe
  • Year and Date: 2006-08-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stereoselective synthesis of (Z)-trifluoromethylalkene dipeptide isosteres and the application to bioactive peptides (2006)
  • Author(s): Inokuchi E., Narumi T., Niida A., Tomita K., Oishi S., Ohno H., Fujii N.
  • Organizer: 33rd Seminars on Organic Reactions
  • Place of Presentation: Kyotanabe
  • Year and Date: 2006-08-03
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ゲノムからりードヘ (2006)
  • Author(s): 藤井信孝
  • Organizer: 第8回ペプチドフォーラム. 「ペプチド・タンパク質合成の革新的方法論とChemical Biologyへの展開」
  • Place of Presentation: 京都
  • Year and Date: 2006-07-01
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] From genome to lead (2006)
  • Author(s): Fujii N.
  • Organizer: The 8th Peptide Forum
  • Place of Presentation: Kyoto
  • Year and Date: 2006-07-01
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] シス型アミド等価体としてのアルケン型ジベプチドイソスターの合成とペプチドトランスポーター(PEPT1)の機能解析への応用 (2005)
  • Author(s): 新居田歩, et al.
  • Organizer: 第24回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 20051128-20051130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 多価官能基を有するフルオロアルケン型ジベブチドイソスターの高立体選択的合成法の開発 (2005)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 第24回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 20051128-20051130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 低分子GPR54作動剤の構造活性相関研究 (2005)
  • Author(s): 富田健嗣, et al.
  • Organizer: 第24回メディシナルケミストリーシンポジウム
  • Place of Presentation: 大阪
  • Year and Date: 20051128-20051130
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of cis-amide equivlalent alkene dipeptide isosteres and the application to peptide transporter PEPT1 (2005)
  • Author(s): Niida A., Tomita K., Tanigaki H., Terada T., Mizumoto M., Ohno H., Tamamura H., Otaka A., Inui K., Fujii N.
  • Organizer: The 24th Symposium on Medicinal Chemistry
  • Place of Presentation: Oosaka
  • Year and Date: 20051128-20051130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stereoselective of multi-functionalized fluoroalkene dipeptide isosteres (2005)
  • Author(s): Narumi T., Niida A., Tomita K, Oishi S., Ohno H., Otaka A., Fujii N.
  • Organizer: The 24th Symposium on Medicinal Chemistry
  • Place of Presentation: Oosaka
  • Year and Date: 20051128-20051130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-activity study on small-molecule GPR54 agonists (2005)
  • Author(s): Tomita K., Niida A., Oishi S., Ohno H., Otaka A., Fujii N.
  • Organizer: The 24th Symposium on Medicinal Chemistry
  • Place of Presentation: Oosaka
  • Year and Date: 20051128-20051130
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] アルケン型ペプチドイソスターを利用したペプチドトランスポーター(PEPT1)の基質認識機構解明の試み (2005)
  • Author(s): 新居田歩., et al.
  • Organizer: 第31回反応と合成の進歩シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 7回膜貫通型GPCRの化学合成を指向した新規光感受性保護基の開発 (2005)
  • Author(s): 上田聡, et al.
  • Organizer: 第31回反応と合成の進歩シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] システイン由来アシルオキサソジノンを利用したチオェステル合成とペプチド合成への展開研究 (2005)
  • Author(s): 太田悠介, et al.
  • Organizer: 第31回反応と合成の進歩シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] [L-Arg, L/D-3-(2-naphthyl)alanine]-タイプ(E)-アルケン型ジペブチドイソスターの立体選択的合成とケモカイン受容体CXCR4アンタゴニストFC131のペブチドミメティツク誘導体の創製への応用 (2005)
  • Author(s): 玉村啓和, et al.
  • Organizer: 第31回反応と合成の進歩シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] システインプロテアーゼ阻害剤、tokaramide Aおよびmiraziridine Aの合成研究 (2005)
  • Author(s): 今野博行, et al.
  • Organizer: 第31回反応と合成の進歩シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] インジウムを用いる位置および立体選択的ラジカル環化反応の開発と応用 (2005)
  • Author(s): 柳田玲子, et al.
  • Organizer: 第31回反応と合成の進歩シンポジウム
  • Place of Presentation: 神戸
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Elucidation of substrate recognition of peptide transporter PEPT1 using alkene-type peptide isosteres (2005)
  • Author(s): Niida A., Tomita K., Tanigaki H., Fujii N., Tamamura H., Otaka A., Terada T., InuiK.
  • Organizer: The 31th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Kobe
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of a novel photo-labile protecting group directed to chemical synthesis of 7TM-GPCR (2005)
  • Author(s): Ueda S., Tomita K., Nomura M., Otaka A., Fujii N.
  • Organizer: The 31th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Kobe
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of thioesters using Cys-derived acyloxazolidinone and the application to peptide synthesis (2005)
  • Author(s): Ohta Y., Itoh S., Fuji N., Otaka A.
  • Organizer: The 31th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Kobe
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stereoselective synthesis of [L-Arg, L/D-3-(2-naphthyl)alanine]-type (E)-alkene dipeptide isostere and the application to analigues of CXCR4 antagonist FC131 (2005)
  • Author(s): Tamamura H., Hiramatsu K., Ueda S., Fujii N., Zixuan W., Peiper SC, Trent, JO., Yamamoto N., Nakajima H., Otaka A.
  • Organizer: The 31th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Kobe
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of cysteine proteases okaramide A and miraziridine A (2005)
  • Author(s): Konno H., Nosaka K., Akaji K., Kubo K, Makabe H., Fujii N.
  • Organizer: The 31th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Kobe
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development and application of indium-mediated regio- and stereo-selective radical cyclization (2005)
  • Author(s): Yanada R., Kohiga S., Nishimori N., Mitsuya H., Fujii N., Takemoto Y.
  • Organizer: The 31th Symposium on Progress in Organic Reactions in the Life Sciences
  • Place of Presentation: Kobe
  • Year and Date: 20051107-20051108
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] アルケン型ペプチドイソスターの合成とペプチドトランスポーター(PEPT1)の構造的要求解明への応用 (2005)
  • Author(s): 新居田歩, et al.
  • Organizer: 第42回ペプチド討論会
  • Place of Presentation: 大阪
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 有機銅試薬を利用したCIS-アルケン型Ala-Proベプチドミメティツクの合成研究 (2005)
  • Author(s): 佐々木義一, et al.
  • Organizer: 第42回ペプチド討論会
  • Place of Presentation: 大阪
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 多価官能基を有するフルオロアルケン型ジベプチドイソスターの高立体選択的合成法の開発を目指して (2005)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 第42回ペプチド討論会
  • Place of Presentation: 大阪
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] RWアミドを有するh0T7T175アゴニストの構造活性相関研究 (2005)
  • Author(s): 富田健嗣, et al.
  • Organizer: 第42回ペプチド討論会
  • Place of Presentation: 大阪
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of peptide thioester based. on N-S acyltransfer utilizing cysleine-derivedacyloxazolidinone with practical application to peptide synthesis (2005)
  • Author(s): 太田悠介, et al.
  • Organizer: 第42回ペプチド討論会
  • Place of Presentation: 大阪
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] CXCR4アンタゴニストFC131のペプチドミメティクスアナログの合成と活性評価 (2005)
  • Author(s): 玉村啓和, et al.
  • Organizer: 第42回ペプチド討論会
  • Place of Presentation: 大阪
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 海綿より単離されたtokaramide Aならびにmiraziridine Aの合成研究 (2005)
  • Author(s): 今野博行, et al.
  • Organizer: 第42回ペプチド討論会
  • Place of Presentation: 大阪
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Synthesis of alkene-type peptide isosteres and the application to peptide transporter PEPT1 (2005)
  • Author(s): Niida A., Tomita K., Tanigaki H., Terada T., Mizumoto M., Ohno H., Tamamura H., Otaka A., Inui K., Fujii N.
  • Organizer: 42th Japanese Peptide Symposium
  • Place of Presentation: Osaka
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of cis-alkene-type Ala-Pro peptidomimetics using organocopper-reagent (2005)
  • Author(s): Sasaki Y., Niida A., Tsuji T., Fujii N., Otaka A.
  • Organizer: 42th Japanese Peptide Symposium
  • Place of Presentation: Osaka
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Stereoselective synthesis of highly functionalized fluoroalkene dipeptide isosteres (2005)
  • Author(s): Narumi T., Niida A., Tomita K., Oishi S., Otaka A., Ohno H., Fujii N.
  • Organizer: 42th Japanese Peptide Symposium
  • Place of Presentation: Osaka
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structure-activity relationship study on RW-amide-type hOT7T175 agonist (2005)
  • Author(s): Tomita K., Niida A., Oishi S., Ohno H., Otaka A., Fujii N.
  • Organizer: 42th Japanese Peptide Symposium
  • Place of Presentation: Osaka
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of peptide thioester based on N-S acyltransfer utilizing cysteine-derived acyloxazolidinone with practical application to peptide synthesis. (2005)
  • Author(s): Ohta Y., Itoh S., Fujii N., Otaka A.
  • Organizer: 42th Japanese Peptide Symposium
  • Place of Presentation: Osaka
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis and bioevaluation of peptidomimetics of CXCR4 antagonist FC131 (2005)
  • Author(s): Tamamura H., Hiramatsu K., Araki T., Ueda S., Oishi S., Esaka R., Zixuan Wang, Stephen C. Peoper, John 0. Trent, Nakajima H., Yamamoto N., Otaka A., Fujii N.
  • Organizer: 42th Japanese Peptide Symposium
  • Place of Presentation: Osaka
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of tokaramide A and miraziridine A isolated from sponges (2005)
  • Author(s): Konno H., Kubo K., Makabe H., Fujii N., Nosaka K., Akaji K.
  • Organizer: 42th Japanese Peptide Symposium
  • Place of Presentation: Osaka
  • Year and Date: 20051027-20051029
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Unequivocal synthesis of (Z)-alkene or (E)-fluoroalkene dipeptide isosteres via DKP mimetics to probe structural requirements of peptide transporter (2005)
  • Author(s): Ayumu Niida, et al.
  • Organizer: 19th American Peptide Symposium
  • Place of Presentation: サンディエゴ
  • Year and Date: 20050618-20050623
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Development of new photoremovable protecting group and its applicationtoward chemical synthesis of 7TM-GPCR (2005)
  • Author(s): Satoshi Ueda, et al.
  • Organizer: 19th American Peptide Symosium
  • Place of Presentation: サンディエゴ
  • Year and Date: 20050618-20050623
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Unequivocal synthesis of (Z)-alkene or (E)-fluoroalkene dipeptide isosteres via DKP mimetics to probe structural orrequirements of peptide transporter. (2005)
  • Author(s): Niida A., Oishi S., Mizumoto M., Sasaki Y., Tomita K., Tamamura H., Otaka A., Terada T., Inui K. Fujii N.
  • Organizer: 19th American Peptide Symposium
  • Place of Presentation: San Diego
  • Year and Date: 20050618-20050623
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of new photoremovable protecting group and its application toward chemical synthesis of 7TM-GPCR (2005)
  • Author(s): Ueda S., Otaka A., Tamamura H., Fujii N.
  • Organizer: 20th American Peptide Symposium
  • Place of Presentation: San Diego
  • Year and Date: 20050618-20050623
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 多価官能基を有するフルオロアルケン型ジペプチドイソスターの高立体選択的合成法の開発 (2005)
  • Author(s): 鳴海哲夫, et al.
  • Organizer: 有機合成若手セミナー
  • Place of Presentation: 神戸
  • Year and Date: 2005-11-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] システイン由来アシルオキサソジノンを利用したチオエステル合成とペプチド合成への展開 (2005)
  • Author(s): 太田悠介, et al.
  • Organizer: 有機合成若手セミナー
  • Place of Presentation: 神戸
  • Year and Date: 2005-11-24
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Stereoselective of multi-functionalized fluoroalkene dipeptide isosteres (2005)
  • Author(s): Narumi T., Niida A., Tomita K., Oishi S., Ohno H., Otaka H., Fujii N.
  • Organizer: Seminar on Organic Synthesis for Young Scientists
  • Place of Presentation: Kobe
  • Year and Date: 2005-11-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of thioesters using Cys-derivec acyloxazolidinone and the application to peptide synthesis (2005)
  • Author(s): Ohta Y., Itoh S., Fujii N., Otaka A.
  • Organizer: Seminar on Organic Synthesis for Young Scientists
  • Place of Presentation: Kobe
  • Year and Date: 2005-11-24
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] ペプチドをリードとした創薬蛋白質核酸酵素増刊ケミカルバイオロジー (2007)
  • Author(s): 大石真也, 他
  • Total Pages: 6
  • Publisher: 共立出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] ケミカルバイオロジーを基盤とするペプチド創薬 (2007)
  • Author(s): 大石真也, 他
  • Total Pages: 5
  • Publisher: メディカルドゥ
  • Description: 「研究成果報告書概要(和文)」より
• [Book] Screening and characterization of cyclic pentapeptide CXCR4 antagonists/inverse agonists using a pheromone responsive reporter gene in Saccharomyces cerevisiae : utility of G protein coupled receptor constitutively active mutants. (2007)
  • Author(s): Zi-xuan Wang, 他
  • Total Pages: 17
  • Publisher: Birkhauser Basel
  • Description: 「研究成果報告書概要(和文)」より
• [Book] プロテオミクスを基盤とするケミカルバイオロジー-情報から制御へ (2006)
  • Author(s): 藤井信孝, 他
  • Total Pages: 6
  • Publisher: オーム社
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] メタスチン誘導体およびその用途 (2008)
  • Inventor(s): 藤井信孝, 大石真也, 富田健嗣
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: 特願2008-119235
  • Filing Date: 2008-04-30
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 新規CXCR4拮抗剤およびその用途 (2008)
  • Inventor(s): 藤井信孝, 浜地格, 王子田彰夫, 玉村啓和
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: 特許第4122441号
  • Acquisition Date: 2008-05-16
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] Eg5阻害剤および該化合物を含有してなる抗癌剤 (2007)
  • Inventor(s): 浅井章良, 澤田潤一, 松野研司, 小郷尚久, 藤井信孝, 大石真也
  • Industrial Property Rights Holder: 有限責任中間法人フアルマIP
  • Industrial Property Number: 特願2007-69487
  • Filing Date: 2007-03-16
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] コイルドコイルを利用した膜タンパク質標識方法 (2007)
  • Inventor(s): 松崎勝巳, 矢野義明, 杉本幸彦, 辻本豪三, 藤井信孝
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: 特願2007-255648
  • Filing Date: 2007-09-28
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] GPR54アゴニスト活性を有する化合物 (2006)
  • Inventor(s): 藤井信孝, 大石真也, 富田健嗣, 新居田歩
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: 特願2006-122305
  • Filing Date: 2006-04-26
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] N36結合ペプチドの製造方法 (2006)
  • Inventor(s): 堤, 石田, 久田, 水本, 秦, 藤井, 松岡, 児玉, 大石
  • Industrial Property Rights Holder: 月桂冠株式会
  • Industrial Property Number: 特願2006-204827
  • Filing Date: 2006-07-27
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 抗FIV剤 (2006)
  • Inventor(s): 辻本元, 藤井信孝
  • Industrial Property Rights Holder: 国立大学法人京都大学, 国立大学法人東京大学
  • Industrial Property Number: 特願2006-242428
  • Filing Date: 2006-09-07
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 抗HIV剤 (2006)
  • Inventor(s): 藤井信孝, 大石真也, 松岡雅雄, 児玉栄
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: 特願2006-290241
  • Filing Date: 2006-10-25
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] CXCR4 antagonists for wound healing and reepithelialization (2005)
  • Inventor(s): Amnon Peled, Nobutaka Fujii
  • Industrial Property Rights Holder: Hadasit Medical Research Services and Development Ltd. Kyoto University
  • Industrial Property Number: US2005-684160
  • Filing Date: 2005-05-25
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas
• [Patent(Industrial Property Rights)] 新規CXCR4拮抗剤およびその用途 (2005)
  • Inventor(s): 藤井信孝, 浜地格, 王子田彰夫, 玉村啓和
  • Industrial Property Rights Holder: 国立大学法人京都大学
  • Industrial Property Number: 特願2006-326069
  • Filing Date: 2005-12-28
  • Description: 「研究成果報告書概要(和文)」より