2007 Fiscal Year Final Research Report Summary
Research on PET Molecular Imaging ofTurners
| Project/Area Number |
17209041
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | University of Fukui |
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Principal Investigator |
FUJIBAYASBI Yasuhisa University of Fukui, Biomedical Imaging Research Center, Professor (50165411)
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| Co-Investigator(Kenkyū-buntansha) |
KIYONO Yasushi University of Fukui, Biomedical Imaging Research Center, Associate Professor (50305603)
MORI Tetsuya University of Fukui, Biomedical Imaging Research Center, Assistant Professor (40397287)
OKAZAWA Hidehiko University of Fukui, Biomedical Imaging Research Center, Professor (50360813)
TOKUNAGA Yuji University of Fukui, Graduate School of Engineering, Associate Professor (80250801)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Cu-64 / F-18-fatty acid / F-18-Estradiol / Cu-ATSMJ / Tumor Stem Cell / Hypoxia / Enerev metabolism |
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| Research Abstract |
New F-18-labeled estradiol as well as F-18-acetic acid synthesis system was developed using a commercially available F-16-fluorodeoxyglucose (FDG) synthesizer. Using this system, clinical research was performed in uterine tumor patients, in comparison with FDG as well as Ga-76-citrate imaging studies. These results indicated that combination PET studies with FES and FDG bring us useful information to distinguish between malignant and benign tumors.
Cu-diacetyl-bis(N-methylthiosemicarbazone) (Cu-ATSM), developed as a hypoxic tumor imaging agent, showed high uptake at the region of low growth in tumor mass. In addition, these regions were rich in so-called "tumor stem cells', well known as hypoxia-registant and low growth rate. These findings indicate that Cu-ATSM can be not only a hypoxia imaging agent, but also an imaging agent for tumor-stem cells or tumor stem cell-rich region. Clinical studies using Cu-62-ATSM is under progress.
Our basic studies on the energy production of tumor cells under hypoxia clarified that, ATP is produced using the enzymatic cleavage of acetyl-CoA to acetic acid. When this shuttle is blocked, tumor cell lost hypoxic tolerance, although grow ability in normoxia is not disturbed. This energy shuttle can be a target of tumor-selective therapy. Acetic acid is not only a final waste in energy production, but a substrate for membrane lipid synthesis. From these findings, it can be said that tumor has a sophisticated ecological system for hypoxia survival/high growth. C-11 and F-18 labeled acetic acids are expected to be agents for the tumor-selective bi-directional acetic acid shuttle.
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Research Products
(68 results)
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[Journal Article] Distinctive FDG and FES accumulation pattern of two tamoxifen-treated patients with endometrial hyperplasia.2008
Author(s)
Tsujikawa, T., Okazawa, H., Yoshida, Y., Mori, T., Kobayashi, M., Tsuchida, T., Fujibayashi, Y
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Journal Title
Ann Nucl Med 22(1)
Pages: 73-7
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The positron emission tomography with F18 17beta-estradiol has the potential to benefit diagnosis and treatment of endometrial cancer2007
Author(s)
Yoshida, Y., Kurokawa, T., Sawamura, Y., Shinagawa, A., Okazawa, H., Fujibayashi, Y., Kotsuji, F
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Journal Title
Gynecol Oncol 104(3)
Pages: 764-6
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A 18F-FDG-positive, 67Ga-negative, and transferrin receptor expression-negative patient with diffuse large B-cell lymphoma2007
Author(s)
Tsujikawa, T., Okazawa, H., Tsuchida, T., Demura, Y., Imamura, Y., Fujibayashi, Y
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Journal Title
Ann Nucl Med 21(6)
Pages: 375-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Itoh, H., In vivo imaging of estrogen receptor concentration in the endometrium and myometrium using FES PET-influence of menstrual cycle and endogenous estrogen level2007
Author(s)
Tsuchida, T., Okazawa, H., Mori, T., Kobayashi, M., Yoshida, Y., Fujibayashi, Y
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Journal Title
Nucl Med Biol 34(2)
Pages: 205-10
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Alkyl-fluorinated thymidine derivatives for imaging cell proliferation I. The in vitro evaluation of some alkyl-fluorinated thymidine derivatives2006
Author(s)
Toyohara, J., Hayashi, A., Gogami, A., Hamada, M., Hamashirna, Y., Katoh, T., Node, M., Fujibayashi, Y
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Journal Title
Nucl Med Biol 33(6)
Pages: 751-64
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Double-tracer autoradiography with Cu-ATSM/FDG and immunohistochemical interpretation in four different mouse implanted tumor models2006
Author(s)
Tanaka, T., Furukawa, T., Fujieda, S., Kasamatsu, S., Yonekura, Y., Fujibayashi, Y
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Journal Title
Nucl Med Biol 33(6)
Pages: 743-50
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] New approach to fully automated synthesis of sodium [18F]fluoroacetate a simple and fast method using a commercial synthesizer2006
Author(s)
Sun, L. Q., Mori, T., Dence, C. S., Fonda, D. E., Welch, M. J., Furukawa, T., Yonekura, Y., Fujibayashi, Y
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Journal Title
Nucl Med Biol 33(1)
Pages: 153-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Automatic synthesis of 16 alpha-[(18)F]fluoro-17beta-estradio] using a cassette-type [(18)F]fluorodeoxyglucose synthesizer2006
Author(s)
Mori, T., Kasamatsu, S, Mosdzianowski, C., Welch, M. J., Yonekura, Y, Fujibayashi, Y
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Journal Title
Nucl Med Biol 33(2)
Pages: 281-6
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Acquisition of resistance to antitumor alkylating agent ACNU : a possible target of positron emission tomography monitoring.2006
Author(s)
Kawai, H., Toyohara, J., Kado, H., Nakagawa, T., Takamatsu, S., Furukawa, T., Yonekura, Y., Kubota, T., Fujibayashi, Y
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Journal Title
Nucl Med Biol 33(1)
Pages: 29-35
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Fujibayashi Y Evaluation of quantitative accuracy using the transmissionless-based emission segmented attenuation correction method in small animal PET2007
Author(s)
Kobayashi, M., Okazawa, H., Oh, M., Tsujikawa, T., Mod, T., Sakai, K., Watanabe, M., Kiyono, Y., Kudo, T., Kawai, K
Organizer
Joint Molecular Imaging Conference, The Society for Molecular Imaging
Place of Presentation
Providence
Year and Date
2007-09-10
Description
「研究成果報告書概要(欧文)」より
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[Presentation] 11C-Acetate PET imaging for renal tumor2007
Author(s)
Oyama, N., Kaneda, T., Nakai, M., Shioyama, R., Miwa, Y., Akino, H., Yokoyama, O., Okazawa, H., Fujibayashi, Y., Yonekura, Y., Welch M.J
Organizer
The 54th Annual Meeting of the Society of Nuclear Medicine
Place of Presentation
Washington DC
Year and Date
2007-06-04
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Differential diagnosis of endometrial hyperplasia and cancer using combined 18F-FES and /8F-FDG PET2007
Author(s)
Tsujikawa, T., Okazawa, H., Yoshida, Y., Mori, T., Kobayashi, K., Tsuchida, T., Y.Fujibayashi
Organizer
The 54th Annual Meeting of the Society of Nuclear Medicine
Place of Presentation
Washington DC
Year and Date
2007-06-04
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Design and application of a general-purpose automatic liquid handling module for PET tracers2007
Author(s)
Mori, T., Hirayama, D., Ido, T., Kasamatsu, S., Asai, T., Fujibayashi, Y
Organizer
17th International Symposium on Radiopharmaceutical Sciences
Place of Presentation
Aachen
Year and Date
2007-05-01
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Nucleophilic 18F-radiolluorination by a modified microwave reactor system2007
Author(s)
Mandap, KS., Ido, T., Hirayama, D., Mori, T., Asai, T., Fujibayashi, Y
Organizer
17th International Symposium on Radiopharmaceutical Sciences
Place of Presentation
Aachen
Year and Date
2007-05-01
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Double Tracer Autoradiography with 18FDG/64Cu-ATSM and Cell Proliferation in tumor2006
Author(s)
Oh, M., Tanaka, T., Kobayashi, M., Furukawa, T., Fujieda, S., Fujibayashi, Y
Organizer
Annual Congress of the European Association of Nuclear Medicine (EANM2006)
Place of Presentation
Athens
Year and Date
2006-10-02
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Fujibayashi Y Evaluation of gynecological tumors and endometriosis using [F-18]-fluoroestradiol and PET2006
Author(s)
Okazawa, H., Yoshida, Y., Mod, T., Tsuchida, T., Kurokawa, T., Kobayashi, M., Tsujikawa, T., Yonekura, Y
Organizer
Annual Congress of the European Association of Nuclear Medicine (EANM2006)
Place of Presentation
Athens, Greece
Year and Date
2006-10-02
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Development of [18F]Ethyl fluoroacetate as a Tracer of Acetate Metabolism imaging in whole body2006
Author(s)
Mori, T., Kobayashi, M., Sun L, Kawashima, H., Kiyono, Y., Fujibayashi, Y
Organizer
The Fifth Annual Meeting of the Society for Molecular Imaging
Place of Presentation
Hawaii
Year and Date
2006-09-01
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Alkyl-fluorinated thymidine derivatives for imaging cell proliferation I. The in vitro evaluation of some alkyl-fluorinated derivatives2006
Author(s)
Toyohara, J., Hayashi, A., Gogami, A., Hamada, M., Hamashima, Y., Kato, T., Node, M., Fujibayashi, Y., thymidine
Organizer
Society of Nuclear Medicine 53rd Annual Meeting
Place of Presentation
San diego
Year and Date
2006-06-05
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Double tracer autoradiography with FDG/Cu-ATSM and immunohistochemical interpretation in 4 different mouse implanted tumor models2005
Author(s)
Tanaka, T., Furukawa, T., Kasamatsu, S., Takamatsu, S., Sunaga, H., Fujieda, H., Naiki, H., Yonekura, Y., Fujibayashi, Y
Organizer
Society of Nuclear Medicine 52nd Annual Meeting
Place of Presentation
Toronto
Year and Date
2005-06-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Fluorine-18 fluoroestradional uptake in endometinm-influence of menstrual cycle and endogenous estrogen level2005
Author(s)
Tsuchida, T., Okazawa, H., Fujibayashi, Y., Mori, T., Tanaka, F., Kobayashi, M., Sugimoto, K., Yonekura, Y., Itou, H
Organizer
Society of Nuclear Medicine 52nd Annual Meeting
Place of Presentation
Toronto
Year and Date
2005-06-20
Description
「研究成果報告書概要(欧文)」より
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[Presentation] In vitro and in vivo evaluation of 18F-fluorothymidine for monitoring tumor proliferation of prostate cancer following anticancer therapy with docetaxel2005
Author(s)
Oyama, N., Kusukawa, N., Miwa, Y., Akino, H., Yokoyama, O., Fujibayashi, Y., Yonekura, Y., Fonda, D E, Dence,S C., Welch M J
Organizer
Society of Nuclear Medicine 52nd Annual Meeting
Place of Presentation
Toronto
Year and Date
2005-06-20
Description
「研究成果報告書概要(欧文)」より
