Regeneration of female reproductive organs and development of animal model of gynecological disease using adult stem cells.

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 17209053
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: YOSHIMURA Yasunori Keio University, School of Medicine, Professor (10129736)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Tetsuo Keio University, School of Medicine, Assistant Professor (10209702) ; UCHIDA Hiroshi Keio University, School of Medicine, Instructor (90286534) ; MATSUZKI Yumi Keio University, School of Medicine, Associate Professor (50338183) ; KAJITANI Takashi Keio University, School of Medicine, Instructor (60407111)
• Project Period (FY): 2005 – 2007
• Keywords: stem cells / regenerative medicine / endometrium / myometrium / animal model / endometriosis

Research Abstract

The human uterus is unique in that it exhibits a tremendous regenerative capacity that enables cyclical regeneration and remodeling throughout a woman's reproductive life. This plasticity of the reproductive system has recently been highlighted. We showed that functional endometrial tissue could be regenerated from only a small number of singly dispersed human endometrial cells, when they were transplanted beneath the kidney capsule of severely immunodeficient mice. This artificially generated endometrium resembles the natural endometrium, and contains human blood vessels which invade the mouse kidney parenchyma. Additionally, it mimics normal hormone-dependent changes including proliferation, differentiation, and tissue breakdown(menstruation). The regenerative capacity of endometrial cells makes them ideal candidates for tissue reconstitution, angiogenesis, and human-mouse chimeric vessel formation. The smooth muscle cells of the uterus (myometrium) share the plasticity of the endometrium. This is evidenced by their capacity for dramatic, repeatable, pregnancy-induced enlargement. Regeneration and remodeling in the female reproductive tract allude to the existence of endometrial and myometrial stem cell systems. Endometrial stem cells have already been described; however, no myometrial stem cells have been identified to date. We have recently isolated candidate populations of adult stem cells from both the human endometrium and myometrium using a Hoechst "side population" method. Characterization of these stem-like cells, along with the study of the mechanisms controlling their regeneration, will improve the understanding of the physiology and pathophysiology of the female reproductive tract. Additionally, myometrial and endometrial stem-like cells might also represent a novel source of biological materials that could be used for the reconstruction of not only the human uterine components but other tissues/organs as well.

Research Products

• [Journal Article] Clinical significance of parental chromosome rearrangements in the management of repeated pregnancy loss (2008)
  • Author(s): Ozawa N, Maruyama T, Nagashima T, Ono M, Arase T, Ishimoto H, Yoshimura Y
  • Journal Title: Fertility and Sterility (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Occipital hemangioma prenatal sonographic and magnetic resonance image (2008)
  • Author(s): Miyakoshi K, Tanaka M, Matsumoto T, Hattori Y, Minegishi K, Ishimoto H, Yoshimura Y
  • Journal Title: J Obstet Gynecol Res (In press)
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Glycodelin blocks progression to S phase and inhibits cell growth a possible progesterone-induced regulator for endometrial epithelial cell growth (2008)
  • Author(s): Ohta K, Maruyama T, Uchida H, Ono M, Nagashima T, Arase T, Kajitani T, Kagami M, Morita M, Yoshimura Y
  • Journal Title: Mol Hum Reprod 14 Pages: 17-22
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Activation of SRC kinase and phosphorylation of STAT5 are required for decidual transformation of human endometrial stromal cells (2008)
  • Author(s): Nagashima T, Maruyama T, Uchida H, Kajitani T, Arase T, Ono M, Oda H, Kagami M, Masuda H, Nishikawa S, Arase H, Yoshimura Y
  • Journal Title: Endocrinology 149 Pages: 1227-1234
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] In vivo Imaging in Humanized Mice (2008)
  • Author(s): Masuda H, Okano.J.H, Maruyama T, Yoshimura Y, Okano H, Matsuzaki Y
  • Journal Title: Current Topics in Microbiology and Immunoloev 324 Pages: 179-197
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Clinical significance of parental chromosome rearrangements in the management of repeated pregnancy loss. (2008)
  • Author(s): Ozawa, N, Maruyama, T, Nagashima, T, Ono, M, Arase, T, Ishimoto, H, Yoshimura, Y
  • Journal Title: Fertility and Sterility (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Occipital hemangioma : prenatal sonographic and magnetic resonance image. (2008)
  • Author(s): Miyakoshi, K, Tanaka, M, Matsumoto, T, Hattori, Y, Minegishi, K, Ishimoto, H, Yoshimura, Y
  • Journal Title: J Obstet Gynecol Res (in press)
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glycodelin blocks progression to S phase and inhibits cell growth : a possible progesterone-induced regulator for endometrial epithelial cell growth. (2008)
  • Author(s): Ohta, K, Maruyama, T, Uchida, H, Ono, M, Nagashima, T, Arase, T, Kajitani, T, Kagami, M, Morita, M, Yoshimura, Y
  • Journal Title: Mol Hum Reprod 14 Pages: 17-22
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Activation of SRC kinase and phosphorylation of STAT5 are required for decidual transformation of human endometrial stromal cells (2008)
  • Author(s): Nagashima, T, Maruyama, T, Uchida, H, Kajitani, T, Arase, T, Ono, M, Oda, H, Kagami, M, Masuda, H, Nishikawa, S, Arase, H, Yoshimura, Y
  • Journal Title: Endocrinology 149 Pages: 1227-1234
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] In vivo Imaging in Humanized Mice (2008)
  • Author(s): Masuda, H, Okano, . J H, Maruyama, T, Yoshimura, Y, Okano, H, Matsuzaki, Y
  • Journal Title: Current Topics in Microbiology and Immunology 324 Pages: 179-197
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin (2007)
  • Author(s): Uchida H, Maruyama T, Ono M, Ohta K, Kajitani T, Masuda H, Nagashima, T, Arase T, Asada H, Yoshimura Y
  • Journal Title: Endocrinology 148 Pages: 896-902
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SLID/gammacnull immunodeficient mice (2007)
  • Author(s): Masuda H, Maruyama T, Hiratsu E, Yamane J, Iwanami A, Nagashima T, Ono M, Miyoshi H, Okano HJ, Ito M, Tamaoki N, Nomura T, Okano H, Matsuzaki Y, Yoshimura Y
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 1925-1930
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis (2007)
  • Author(s): Nagashima T, Maruyama T, Furuya M, Kajitani T, Uchida H, Masuda H, Ono M Arase T, Ozato K, Yoshimura Y
  • Journal Title: Mol Hum Reprod 13 Pages: 141-148
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Haplotype analysis of the estrogen receptor 1 gene in male genital and reproductive abnormalities (2007)
  • Author(s): Watanabe M, Yoshida R, Ueoka K, Aoki K, Sasagawa I, Hasegawa T, Sueoka K, Kamatani N, Yoshimura Y. Oaata T
  • Journal Title: Hum Reprod 22 Pages: 1279-1284
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] 'Working'cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells (2007)
  • Author(s): Okamoto K, Miyoshi S, Toyoda M, Hida N, Ikegami Y, Makino H, Nishiyama N, Tsuji H, Cui CH, Segawa K, Uyama T, Kami D, Miyado K, Asada H, Matsumoto K, Saito H, Yoshimura Y, Ogawa S, Aeba R, Yozu R, Umezawa A
  • Journal Title: Exp Cell Res 313 Pages: 2550-2562
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Hlfoo is indispensable for meiotic maturation of the mouse oocyte (2007)
  • Author(s): Furuya M, Tanaka M, Teranishi T, Matsumoto K, Hosoi Y, Saeki K, Ishimoto H, Minegishi K, Iritani A, Yoshimura Y
  • Journal Title: J Reprod Dev 53 Pages: 895-902
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Elimination of HN-1 from semen and application of the processed semen to assisted reproductive technology (2007)
  • Author(s): Kuji N, Mizusawa Y, Naganishi M, Hamatani T, Iwata S, Yoshimura Y
  • Journal Title: Reprod Med Biol 6 Pages: 151-156
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The development of novel quantification assay for mitochondrial DNA heteroplasmy aimed at preimplantation genetic diagnosis of Leigh encephalopathy (2007)
  • Author(s): Tajima H, Sueoka K, Moon SY, Nakabayashi A, Sakurai T, Murakoshi Y, Watanabe H, Iwata S, Hashiba T, Kato S, Goto YI, Yoshimura Y
  • Journal Title: J Assist Reprod Genet 24 Pages: 227-232
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Well-devised quantification analysis for duplication mutation of Duchenne muscular dystrophy aimed at preimplantation genetic diagnosis (2007)
  • Author(s): Nakabayashi A, Sueoka K, Tajima H, Sato K, Sakamoto Y, Katou S, Yoshimura Y
  • Journal Title: J Assist Reprod Genet 24 Pages: 233-240
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Side population in human uterine myometrium displays phynotypic and functional characteristics of myometrial stem cells (2007)
  • Author(s): Ono M, Maruyama T, Masuda H, Kajitani T, Nagashima T, Arase T, Ito M, Ohta K, Uchida H, Asada H, Yoshimura Y, Okano H, Matsuzaki Y
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 18700-18705
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Human amniotic membrane-derived stem cell with lack of Hla-dr expression can be a promising cellular source for cardiac stem cell therapy (2007)
  • Author(s): Ikegami Y, Tsuji H, Miyoshi S, Hida N, Asada H, Uyama T, Umezawa A, Yoshimura Y, Oeawa S
  • Journal Title: J Am Coil cardiol 49 Pages: 47A
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation (2007)
  • Author(s): Uchida H, Maruyama T, Ohta K, Ono M, Arase T, Kagami M, Oda H, Kajitani T, Asada H, Toshimura Y
  • Journal Title: Human Reproduction 22 Pages: 2615-2622
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Analysis of serum FSH bioactivity in a patient with an FSH-secreting pituitary microadenoma and multicystic ovaries A Case report (2007)
  • Author(s): Kajitani T, Shunyu L, Maruyama T, Uchida H, Sakurai R, Masuda H, Nagashima T, Ono M, Arase T, Yoshimura Y
  • Journal Title: Hum Reprod 23 Pages: 435-439
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Histone deacetylase inhibitors stimulate cell migration in human endometrial adenocarcinoma cells through up-regulation of glycodelin. (2007)
  • Author(s): Uchida, H, Maruyama, T, Ono, M, Ohta, K, Kajitani, T, Masuda, H, TNagashima, T, Arase, T, Asada, H, Yoshimura, Y
  • Journal Title: Endocrinology 148 Pages: 896-902
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Noninvasive and real-time assessment of reconstructed functional human endometriumin NOD/SCID/gammacnull immunodeficient mice. (2007)
  • Author(s): Masuda, H, Maruyama, T, Hiratsu, E, Yamane, J, Iwanami, A, Nagashima, T, Ono, M, Miyoshi, H, Okano, HJ, Ito, M, Tamaoki, N, Nomura, T, Okano, H, Matsuzaki, Y, Yoshimura, Y
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 1925-1930
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Histone acetylation and subcellular localization of chromosomal protein BRD4 during mouse oocyte meiosis and mitosis. (2007)
  • Author(s): Nagashima, T, Maruyama, T, Furuya, M, Kajitani, T, Uchida, H, Masuda, H, Ono, M, Arase, T, Ozato, K, Yoshimura, Y
  • Journal Title: Mol Hum Reprod 13 Pages: 141-148
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Haplotype analysis of the estrogen receptor 1 gene in male genital and reproductive abnormalities. (2007)
  • Author(s): Watanabe, M, Yoshida, R, Ueoka, K, Aoki, K, Sasagawa, I, Hasegawa, T, Sueoka, K, Kamatani, N, Yoshimura, Y, Ogata, T
  • Journal Title: Hum Reprod 22 Pages: 1279-1284
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Working' cardiomyocytes exhibiting plateau action potentials from human placenta-derived extraembryonic mesodermal cells. (2007)
  • Author(s): Okamoto, K, Miyoshi, S, Toyoda, M, Hida, N, Ikegami, Y, Makino, H, Nishiyama, N, Tsuji, H, Cui, CH, Segawa, K, Uyama, T, Kami, D, Miyado, K, Asada, H, Matsumoto, K, Saito, H, Yoshimura, Y, Ogawa, S, Aeba, R, Yozu, R, Umezawa, A
  • Journal Title: Exp Cell Res 313 Pages: 2550-2562
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Hlfoo is indispensable for meiotic maturation of the mouse oocyte. (2007)
  • Author(s): Furuya, M, Tanaka, M, Teranishi, T, Matsumoto, K, Hosoi, Y, Saeki, K, Ishimoto, H, Minegishi, K, Iritani, A, Yoshimura, Y
  • Journal Title: J Reprod Dev 53 Pages: 895-902
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Elimination of HIV-1 from semen and application of the processed semen to assisted reproductive technology. (2007)
  • Author(s): Kuji, N, Mizusawa, Y, Naganishi, M, Hamatani, T, Iwata, S, Yoshimura, Y
  • Journal Title: Reprod Med Biol 6 Pages: 151-156
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The development of novel quantification assay for mitochondrial DNA heteroplasmy aimed at preimplantation genetic diagnosis of Leigh encephalopathy. (2007)
  • Author(s): Tajima, H, Sueoka, K, Moon, SY, Nakabayashi, A, Sakurai, T, Murakoshi, Y, Watanabe, H, Iwata, S, Hashiba, T, Kato, S, Goto, YI, Yoshimura, Y
  • Journal Title: J Assist Reprod Genet 24 Pages: 227-232
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Well-devised quantification analysis for duplication mutation of Duchenne muscular dystrophy aimed at preimplantation genetic diagnosis. (2007)
  • Author(s): Nakabayashi, A, Sueoka, K, Tajima, H, Sato, K, Sakamoto, Y, Katou, S, Yoshimura, Y
  • Journal Title: J Assist Reprod Genet 24 Pages: 233-240
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Side population in human uterine myometrium displays phynotypic and functional characteristics of myometrial stem cells. (2007)
  • Author(s): Ono, M, Maruyama, T, Masuda, H, Kajitani, T, Nagashima, T, Arase, T, Ito, M, Ohta, K, Uchida, H, Asada, H, Yoshimura, Y, Okano, H, Matsuzaki, Y
  • Journal Title: Proc Natl Acad Sci USA 104 Pages: 18700-18705
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human amniotic membrane-derived stem cell with lack of H la-dr expression can be a promising cellular source for cardiac stem cell therapy. (2007)
  • Author(s): Ikegami, Y, Tsuji, H, Miyoshi, S, Hida, N, Asada, H, Uyama, T, Umezawa, A, Yoshimura, Y, Ogawa, S
  • Journal Title: J Am Coll cardiol 49 Pages: 47A
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Histone deacetylase inhibitor-induced glycodelin enhances the initial step of implantation. (2007)
  • Author(s): Uchida, H, Maruyama, T, Ohta, K, Ono, M, Arase, T, Kagami, M, Oda, H, Kajitani, T, Asada, H, Toshimura, Y
  • Journal Title: Human Reproduction 22 Pages: 2615-2622
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Analysis of serum FSH bioactivity in a patient with an FSH-secreting pituitary microadenoma and multicystic ovaries : A Case report. (2007)
  • Author(s): Kajitani, T, Shunyu, L, Maruyama, T, Uchida, H, Sakurai, R, Masuda, H, Nagashima, T, Ono, M, Arase, T, Yoshimura, Y
  • Journal Title: Hum Reprod 23 Pages: 435-439
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Human endometrial cytodifferentiation by histone deacetylase inhibitors (2006)
  • Author(s): Uchida H, Maruyama T, Nagashima T, Ono M, Masuda H, Arase T, Sugiura I, Onouchi M, Kajitani T, Asada H, Yoshimura Y
  • Journal Title: Hum Cell 19 Pages: 38-42
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Bioethical aspects of regenerative and reproductive medicine (2006)
  • Author(s): Yoshimura Y
  • Journal Title: Hum Cell 19 Pages: 83-86
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Differential zonal expression and adrenocorticotropin regulation of SPARC,a matricellular protein,in the midgestation human fetal adrenal gland implications for adrenal development (2006)
  • Author(s): Ishimoto H, Ginzinger DG, Matsumoto T, Hattori Y, Furuya M, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB
  • Journal Title: J Clin Endocrinol Metab 91 Pages: 3208-3214
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Midkine,a heparin-binding growth factor,selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland (2006)
  • Author(s): Ishimoto H, Muench MO, Higuchi T, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB
  • Journal Title: J Clin End Metab 91 Pages: 4050-4056
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Complete removal of HIV-1 RNA and proviral DNA from semen by the swim-up method assisted reproduction technique using spermatozoa free from HIV-1 (2006)
  • Author(s): Kato S, Hanabusa H, Kaneko S, Takakuwa K, Suzuki M, Kuji N, Jinno M, Tanaka R, Kojima K, Iwashita M, Yoshimura Y, Tanaka K
  • Journal Title: AIDS 20 Pages: 967-973
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Global gene expression profiling of preimplantation embryos (2006)
  • Author(s): Hamatani T, Ko Minoru Sh, Yamada M, Kuji N, Mizusawa Y, Shoji M, Hada T, Asada H, Maruvama T, Yoshimura Y
  • Journal Title: Hum Cell 19 Pages: 98-117
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Human endometrial cytodifferentiation by histone deacetylase inhibitors. (2006)
  • Author(s): Uchida, H, Maruyama, T, Nagashima, T, Ono, M, Masuda, H, Arase, T, Sugiura, I, Onouchi, M, Kajitani, T, Asada, H, Yoshimura, Y
  • Journal Title: Hum Cell 19 Pages: 38-42
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Bioethical aspects of regenerative and reproductive medicine (2006)
  • Author(s): Yoshimura, Y
  • Journal Title: Hum Cell 19 Pages: 3208-3214
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Differential zonal expression and adrenocorticotropin regulation of SPARC, a matricellular protein, in the midgestation human fetal adrenal gland : implications for adrenal development (2006)
  • Author(s): Ishimoto, H, Ginzinger, DG, Matsumoto, T, Hattori, Y, Furuya, M, Minegishi, K, Tanaka, M, Yoshimura, Y, Jaffe, RB
  • Journal Title: Hum Cell 91 Pages: 4050-4056
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Midkine, a heparin-binding growth factor, selectively stimulates proliferation of definitive zone cells of the human fetal adrenal gland. (2006)
  • Author(s): Ishimoto, H, Muench, MO, Higuchi, T, Minegishi, K, Tanaka, M, Yoshimura, Y, Jaffe, RB
  • Journal Title: J Clin End Metab 91 Pages: 4050-4056
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Complete removal of HIV-1 RNA and proviral DNA from semen by the swim-up method : assisted reproduction technique using spermatozoa free from HIV-1. (2006)
  • Author(s): Kato, S, Hanabusa, H, Kaneko, S, Takakuwa, K, Suzuki, M, Kuji, N, Jinno, M, Tanaka, R, Kojima, K, Iwashita, M, Yoshimura, Y, Tanaka, K
  • Journal Title: AIDS 20 Pages: 967-973
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Global gene expression profiling of preimplantation embryos. (2006)
  • Author(s): Hamatani, T, Ko Minoru, Sh, Yamada, M, Kuji, N, Mizusawa, Y, Shoji, M, Hada, T, Asada, H, Maruyama, T, Yoshimura, Y
  • Journal Title: Hum Cell 19 Pages: 98-117
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Protein kinase a activity and protein phosphorylation during the mouse sperm acrosomal reaction (2005)
  • Author(s): Kuji N, Tanaka Y, Komatsu S, Yoshimura Y
  • Journal Title: Arch Androl 51 Pages: 55-64
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] A reduction in intraovarian arterial blood flow resistance after ovulation is necessary to achieve pregnancy in natural cycle (2005)
  • Author(s): Nakagawa K, Ozawa N, Takamatsu K, Takahashi Y, Irahara M, Yoshimura Y, Saito H
  • Journal Title: J Assist Reprod Gene 22 Pages: 9-14
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Follicle stimulating hormone-secreting pituitary microadenoma with fluctuating levels of ovarian hyperstimulation (2005)
  • Author(s): Maruyama T, Masuda H, Uchida H, Nagashima T, Yoshimura Y
  • Journal Title: Obstet Gynecol 105 Pages: 1215-1218
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Histone acetylation in reproductive organs Significance of histone deacetylase inhibitors in gene transcription (2005)
  • Author(s): Uchida H, Maruyama T, Arase T, Ono M, Nagashima T, Masuda H, A sada H, Yoshimura Y
  • Journal Title: Reprod Med Biol 4 Pages: 115-122
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Prenatal diagnosis of hemifacial microsomia by magnetic resonance imaging (2005)
  • Author(s): Hattori Y, Tanaka M, Matsumoto T, Uehara K, Ueno K, Minegishi K, Ishimoto H, Miyakoshi K, Y oshimura Y
  • Journal Title: J Perinat Med 33 Pages: 69-71
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Gonadotrophin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1: renort of three families Case report (2005)
  • Author(s): Sato N, Hasegawa T, Hori N, Fukami M, Yoshimura Y, Ogata T
  • Journal Title: Hum Reprod 20 Pages: 2173-2178
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Iridic and retinal coloboma associated with prenatal methimazole exposure (2005)
  • Author(s): Aramaki M, Hokuto I, Matsumoto T, Ishimoto H, Inoue M, Kimura T, Oikawa Y, Ikeda K, Yoshimura Y, Takahashi T, Kosaki K
  • Journal Title: Am J Med Genet 139A(2) Pages: 156-158
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Fine resolution of human sperm nucleoproteins by two-dimensional electrophoresis (2005)
  • Author(s): Yoshii T, Kuji N, Komatsu S, Iwahashi K, Tanaka Y, Yoshida H, Wada A. Yoshimura Y
  • Journal Title: Mol Hum Reprod 11 Pages: 677-681
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Impairment of decidualization in SRC-Def.cient mice (2005)
  • Author(s): Shimizu A, Maruyama T, Tamaki K, Uchida H, Asada H, Yoshimura Y
  • Journal Title: Biol Reprod 73 Pages: 1219-1227
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin (2005)
  • Author(s): Uchida H, Maruyama T, Nagashima T, Asada H, Yoshimura Y
  • Journal Title: Endocrinology 146 Pages: 5365-5373
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Case of iatrogenic dysmenorrheal in non-communicating rudimentary uterine horn and its laparoscopic resection (2005)
  • Author(s): Tanaka Y, Asada H, Uchida H, Maruyama T, Kuji N, Sueoka K, Yoshimura Y
  • Journal Title: J Obstet Gynaecol Res 31 Pages: 242-246
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] The "Spanning Protocol": A new DNA extraction method for efficient single-cell genetic diagnosis (2005)
  • Author(s): Tsuchiya S, Sueoka K, Matsuda N, Tanigaki R, Asada H, Hashiba T, Kato S, Yoshimura Y
  • Journal Title: J Assist Reprod Genet 22 Pages: 407-414
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Association of common LH variant with hyperfunctional promoter in a Japanese infertile woman (2005)
  • Author(s): Liu S, Ogata T, Maruyama T, Yoshimura Y, I shizuka B
  • Journal Title: Endocr J 52 Pages: 781-784
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Melatonin as a local regulator of human placental function (2005)
  • Author(s): Iwasaki S, Nakazawa K, Sakai J, Kometani K, Iwashita M, Yoshimura Y, Maruvama T
  • Journal Title: J Pineal Res 39 Pages: 261-265
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Carbon monoxide as a guardian against hepatobiliary dysfunction (2005)
  • Author(s): Suematsu M, Tsukada K, Tajima T, Yamamoto T, Ochiai D, Watanabe H, Yoshimura Y, Goda N
  • Journal Title: Alcohol Clin Exp Res 29 Pages: 134S-139S
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Protein kinase a activity and protein phosphorylation during the mouse sperm acrosomal reaction (2005)
  • Author(s): Kuji, N, Tanaka, Y, Komatsu, S, Yoshimura, Y
  • Journal Title: Arch Androl 51 Pages: 55-64
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] A reduction in intraovarian arterial blood flow resistance after ovulation is necessary to achieve pregnancy in natural cycle (2005)
  • Author(s): Nakagawa, K, Ozawa, N, Takamatsu, K, Takahashi, Y, Irahara, M, Yoshimura, Y, Saito, H
  • Journal Title: J Assist Reprod Gene 22 Pages: 9-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Follicle stimulating hormone-secreting pituitary microadenoma with fluctuating levels of ovarian hyperstimulation (2005)
  • Author(s): Maruyama, T, Masuda, H, Uchida, H, Nagashima, T, Yoshimura, Y
  • Journal Title: Obstet Gynecol 105 Pages: 1215-1218
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Histone acetylation in reproductive organs : Significance of histone deacetylase inhibitors in gene transcription (2005)
  • Author(s): Uchida, H, Maruyama, T, Arase, T, Ono, M, Nagashima, T, Masuda, H, Asada, H, Yoshimura, Y
  • Journal Title: Reprod Med Bio 4 Pages: 115-122
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Prenatal diagnosis of hemifacial microsomia by magnetic resonance imaging (2005)
  • Author(s): Hattori, Y, Tanaka, M, Matsumoto, T, Uehara, K, Ueno, K, Minegishi, K, Ishimoto, H, Miyakoshi, K, Yoshimura, Y
  • Journal Title: J Perinat Med 33 Pages: 69-71
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Gonadotrophin therapy in Kallmann syndrome caused by heterozygous mutations of the gene for fibroblast growth factor receptor 1 : report of three families : Case report (2005)
  • Author(s): Sato, N, Hasegawa, T, Hori, N, Fukami, M, Yoshimura, Y, Ogata, T
  • Journal Title: Hum Reprod 20 Pages: 2173-2178
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Iridic and retinal coloboma associated with prenatal methimazole exposure (2005)
  • Author(s): Aramaki, M, Hokuto, I, Matsumoto, T, Ishimoto, H, Inoue, M, Kimura, T, Oikawa, Y, Ikeda, K, Yoshimura, Y, Takahashi, T, Kosaki, K
  • Journal Title: Am J Med Genet 139A(2) Pages: 156-158
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] VFine resolution of human sperm nucleoproteins by two-dimensional electrophoresis (2005)
  • Author(s): Yoshii, T, Kuji, N, Komatsu, S, Iwahashi, K, Tanaka, Y, Yoshida, H, Wada, A, Yoshimura, Y
  • Journal Title: Mol Hum Reprod 11 Pages: 677-681
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Impairment of decidualization in SRC-Deficient mice (2005)
  • Author(s): Shimizu, A, Maruyama, T, Tamaki, K, Uchida, H, Asada, H, Yoshimura, Y
  • Journal Title: Biol Reprod 73 Pages: 1219-1227
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Histone deacetylase inhibitors induce differentiation of human endometrial adenocarcinoma cells through up-regulation of glycodelin (2005)
  • Author(s): Uchida, H, Maruyama, T, Nagashima, T, Asada, H, Yoshimura, Y
  • Journal Title: Endocrinology 146 Pages: 5365-5373
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Case of iatrogenic dysmenorrheal in non-communicating rudimentary uterine horn and its lap aroscopic resection (2005)
  • Author(s): Tanaka, Y, Asada, H, Uchida, H, Maruyama, T, Kuji, N, Sueoka, K, Yoshimura, Y
  • Journal Title: J Obstet Gynaecol Res 31 Pages: 242-246
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The "Spanning Protocol" : A new DNA extraction method for efficient single-cell genetic diagnosis. (2005)
  • Author(s): Tsuchiya, S, Sueoka, K, Matsuda, N, Tanigaki, R, Asada, H, Hashiba, T, Kato, S, Yoshimura, Y
  • Journal Title: J Assist Reprod Genet 22 Pages: 407-414
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Association of common LH variant with hyperfunctiona : promoter in a Japanese infertile woman. (2005)
  • Author(s): Liu, S, Ogata, T, Maruyama, T, Yoshimura, Y, Ishizuka, B
  • Journal Title: Endocr J 52 Pages: 781-784
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Melatonin as a local regulator of human placental function. (2005)
  • Author(s): Iwasaki, S, Nakazawa, K, Sakai, J, Kometani, K, Iwashita, M, Yoshimura, Y, Maruyama, T
  • Journal Title: J Pineal Res 39 Pages: 261-265
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Carbon monoxide as a guardian against hepatobiliary dysfunction. (2005)
  • Author(s): Suematsu, M, Tsukada, K, Tajima, T, Yamamoto, T, Ochiai, D, Watanabe, H, Yoshimura, Y, Goda, N
  • Journal Title: Alcohol Clin Exp Res 29 Pages: 134S-139S
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Human amniotic membrane-derived mesenchymal stem cell acquired immunological olerance by HLA G expression and differentiated cardiomyocyte in vivo (2008)
  • Author(s): Tsuji H, Ikegami Y, Miyoshi S, Hida N, Nishiyama N, Togashi I, Nakamizo H, Asada H, Uyama T, Tanaka M, Segawa K, Inoue J, Ogawa S, Yoshimura Y, Umezawa A
  • Organizer: 57th Annual Scientific Session American College of Cardiology
  • Place of Presentation: Chicago,USA
  • Year and Date: 20080329-0401
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Human amniotic membrane-derived mesenchymal stem cell acquired immunological olerance by HLA-G expression and differentiated cardiomyocyte in vivo. (2008)
  • Author(s): Tsuji, H, Ikegami, Y, Miyoshi, S, Hida, N, Nishiyama, N, Togashi, I, Nakamizo, H, Asada, H, Uyama, T, Tanaka, M, Segawa, K, Inoue, J, Ogawa, S, Yoshimura, Y, Umezawa, A
  • Organizer: 57th Annual Scientific Session American College of Cardiology
  • Place of Presentation: Chicago(USA)
  • Year and Date: 20080329-0401
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] UDP-glucose and its receptor P2Y14 as a new innate immune system in the female reproductive tract (2008)
  • Author(s): Arase T, Maruyama T, Uchida H, Kajitani T, Ono M, Kagami M, Asada H, Yoshimura Y
  • Organizer: 55th Society for Gynecologic Investigation
  • Place of Presentation: San Diego,USA
  • Year and Date: 20080326-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] N-Cadherin Regulates Epithelio-Mesenchymal Transition and Endometrial Ephithelial Cell Dynamics during Human Implantation (2008)
  • Author(s): Uchida H, Maruyama T, Arase T, Ono M, Kajitani T, Kagami M, Oda H, Nishiakawa S, Yoshimura Y
  • Organizer: 55th Society for Gynecologic Investigation
  • Place of Presentation: San Diego,USA
  • Year and Date: 20080326-29
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] UDP-glucose and its receptor P2Y14 as a new innate immune system in the female reproductive tract. (2008)
  • Author(s): Arase, T, Maruyama, T, Uchida, H, Kajitani, T, Ono, M, Kagami, M, Asada, H, Yoshimura, Y
  • Organizer: 55th Society for Gynecologic Investigation
  • Place of Presentation: San Diego(USA)
  • Year and Date: 20080326-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] N- Cadherin Regulates Epithelio-Mesenchymal Transition and Endometrial Ephithelial Cell Dynamics during Human Implantation. (2008)
  • Author(s): Uchida, H, Maruyama, T, Arase, T, Ono, M, Kajitani, T, Kagami, M, Oda, H, Nishiakawa, S, Yoshimura, Y
  • Organizer: 55th Society for Gynecologic Investigation
  • Place of Presentation: San Diego(USA)
  • Year and Date: 20080326-29
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression analysis of pain-related genesin endometriosis and adenomyosis (2008)
  • Author(s): Kajitani T, Maruyama, T, Asada H, Ono M, Arase T, Kagami M, Oda H, Nishikawa S, Uchida H, Yoshimura Y
  • Organizer: 10th World Congress on Endometriosis
  • Place of Presentation: Australia,Melbourne
  • Year and Date: 20080311-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Genome wide approaches for identification of novel endometri osis-associated genes (2008)
  • Author(s): Maruyama T, Kajitani T, Oda H, Nishikawa S, Arase T, Kagami M, Ono M, Asada H, Uchida, H Yoshimura Y
  • Organizer: 10th World Congress on Endimetriosis
  • Place of Presentation: Australia,Melbourne
  • Year and Date: 20080311-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression analysis of pain-related gene sin endometriosis and adenomyosis (2008)
  • Author(s): Kajitani, T, Maruyama, T, Asada, H, Ono, M, Arase, T, Kagami, M, Oda, H, Nishikawa, S, Uchida, H, Yoshimura, Y
  • Organizer: 10th World Congress on Endimetriosis
  • Place of Presentation: Australia (Melbourne)
  • Year and Date: 20080311-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Genome-wide approaches for identification of novel end ometriosis-associated genes (2008)
  • Author(s): Maruyama, T, Kajitani, T, Oda, H, Nishikawa, S, Arase, T, Kagami, M, Ono, M, Asada, H, Uchida, H, Yoshimura, Y
  • Organizer: 10th World Congress on Endimetriosis
  • Place of Presentation: Australia (Melbourne)
  • Year and Date: 20080311-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Identification of a novel gene encoding a B-box zinc finger protein and its specific expression and essential role during nreimnlantation development (2007)
  • Author(s): Yamada M, Hamatani T, Akutsu H, Kuji N, Umezawa A, Yoshimura Y
  • Organizer: American Society for Reproductive Medicine 63rd Annual Meeting
  • Place of Presentation: Washington DC,USA
  • Year and Date: 20071012-17
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Identification of a novel gene encoding a B-box zinc finger protein and its specific expression and essential role during preimplantation development. (2007)
  • Author(s): Yamada, M, Hamatani, T, Akutsu, H, Kuji, N, Umezawa, A, Yoshimura Y
  • Organizer: American Society for Reproductive Medicine 63rd Annual Meeting
  • Place of Presentation: Washington DC(USA)
  • Year and Date: 20071012-17
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Blastomere selection to discriminate fragmentation is a key for highly accurate preimplantation genetic diagnosis (2007)
  • Author(s): Sakurai T, Sueoka K, Sato S, Murakoshi Y, Watanabe H, Nakabayashi A, Tajima H, Sato K, Hashiba T, Iwata S, Kuji N, Asada H, Aoki D, Yoshimura Y
  • Organizer: 7th Preimplantation Genetic Diagnosis International Society Conference
  • Place of Presentation: Melbourne,Australia
  • Year and Date: 20070613-16
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Blastomere selection to discriminate fragmentation is a key for highly accurate preimplantation genetic diagnosis. (2007)
  • Author(s): Sakurai, T, Sueoka, K, Sato, S, Murakoshi, Y, Watanabe, H, Nakabayashi, A, Tajima, H, Sato, K, Hashiba, T, Iwata, S, Kuji, N, Asada, H, Aoki, D, Yoshimura, Y
  • Organizer: 7th. Preimplantation Genetic Diagnosis International Society Conference
  • Place of Presentation: Melbourne(Australia)
  • Year and Date: 20070613-16
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Down-regulatin of ACTH receptor gene expression by an ACTH-inducible heparin-binding growth factor,midkine in human fetal adrenal cells (2007)
  • Author(s): Ishimoto H, Higuchi T, Asai S, Minegishi K, Tanaka M. Yoshimura Y. Jaffe RB
  • Organizer: 89th Annual Meeting of The Endocrine Society
  • Place of Presentation: Toronto,Canada
  • Year and Date: 20070612-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression profile of a heparin-binding growth factor, midkine,in human fetal tissues and the placenta (2007)
  • Author(s): Higuchi T, Ishimoto H, Asai S, Minegishi K, Tanaka M, Jaffe RB, Yoshimura Y
  • Organizer: 89th Annual Meeting of The Endocrine Society
  • Place of Presentation: Toronto,Canada
  • Year and Date: 20070612-15
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Down-regulatin of ACTH receptor gene expression by an ACTH-inducible heparin-binding growth factor, midkine in human fetal adrenal cells. (2007)
  • Author(s): Ishimoto, H, Higuchi, T, Asai, S, Minegishi, K, Tanaka, M, Yoshimura, Y, Jaffe, RB
  • Organizer: 89th Annual Meeting of The Endocrine Society
  • Place of Presentation: Toronto(Canada)
  • Year and Date: 20070612-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression profile of a heparin-binding growth factor, midkine, in human fetal tissues and the placenta. (2007)
  • Author(s): Higuchi, T, Ishimoto, H, Asai, S, Minegishi, K, Tanaka, M, Jaffe, RB, Yoshimura, Y
  • Organizer: 89th Annual Meeting of The Endocrine Society
  • Place of Presentation: Toronto(Canada)
  • Year and Date: 20070612-15
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regeneration and adult stem cells in human uterus. (2007)
  • Author(s): Yoshimura, Y
  • Organizer: 2007 Annual Meeting of Taiwan Association of Obstetrics and Gynecology
  • Place of Presentation: Taipei(Taiwan)
  • Year and Date: 20070301-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Regeneration and adult stem cells in human uterus (2007)
  • Author(s): Yoshimura Y
  • Organizer: 2007 Annual Meeting of Taiwan Association of Obstetrics and Gynecology
  • Place of Presentation: Taipei,Taiwan
  • Year and Date: 20070301-03
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Syndecan-3 localization is limited to the definitive zone of the human fetal adrenal gland Implications for adrenal development (2007)
  • Author(s): Ishimoto H, Asai S, Higuchi T, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno,USA
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The outer zone of the human fetal adrenal gland is a site of angiogenesis (2007)
  • Author(s): Ishimoto H, Asai S, Minegishi K, Tanaka M, Yoshimura Y, Jaffe RB
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno,USA
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] P2Y14/GPR105, a G protein-coupled receptor for UDP-glucose, is involved in the up-regulation of interleukin-8 in endometrial cells: Implications for endometrial immune system (2007)
  • Author(s): Arase T, Maruyama T, Uchida H, Kajitani T, Ono M, Nagashima T, Ohta K, Kagami M, Masuda H, Asada H, Yoshimura Y
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno, USA
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression and localization of nerve growoth factor in the endometriotic and adenomyotic lesions (2007)
  • Author(s): Kajitani T, Maruyama T, Asada H, Uchida H, Masuda H, Nagashima T, Ono M, Arase T, Ohta K, Kagami M, Yoshimura Y
  • Organizer: 54th Annual Scientific Meeting of Society for Gvnecologic Investigation
  • Place of Presentation: Reno,USA
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Glycodelin inhibits progression to S phase and cell proliferation in human endometrial epithelial cells (2007)
  • Author(s): Ohta K, Maruyama T, Uchida H, Ono M, Nagashima T, Arase T, Kajitani T, Kagami M, Asada H, Morita M, Yoshimura Y
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno,USA
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Syndecan-3 localization is limited to the definitive zone of the human fetal adrenal gland : Implications for adrenal development. (2007)
  • Author(s): Ishimoto, H, Asai, S, Higuchi, T, Minegishi, K, Tanaka, M, Yoshimura, Y, Jaffe, RB
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno(USA)
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The outer zone of the human fetal adrenal gland is a site of angiogenesis. (2007)
  • Author(s): Ishimoto, H, Asai, S, Minegishi, K, Tanaka, M, Yoshimura, Y, Jaffe, RB
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno (USA)
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] P2Y14/GPR105, a G protein-coupled receptor for UDP-glucose, is involved in the up-regulation of interleukin-8 in endometrial cells : Implications for endometrial immune system. (2007)
  • Author(s): Arase, T, Maruyama, T, Uchida, H, Kajitani, T, Ono, M, Nagashima, T, Ohta, K, Kagami, M, Masuda, H, Asada, H, Yoshimura, Y
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno(USA)
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression and localization of nerve growoth factor in the endometriotic and adenomyotic lesions. (2007)
  • Author(s): Kajitani, T, Maruyama, T, Asada, H, Uchida, H, Masuda, H, Nagashima, T, Ono, M, Arase, T, Ohta, K, Kagami, M, Yoshimura, Y
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno (USA)
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Glycodelin inhibits progression to S phase and cell proliferation in human endometrial epithelial cells. (2007)
  • Author(s): Ohta, K, Maruyama, T, Uchida, H, Ono, M, Nagashima, T, Arase, T, Kajitani, T, Kagami, M, Asada, H, Morita, M, Yoshimura, Y
  • Organizer: 54th Annual Scientific Meeting of Society for Gynecologic Investigation
  • Place of Presentation: Reno(USA)
  • Year and Date: 2007-03-14
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SLID/gamma(c)(null) immunodeficient mice Its potential application as an endometriosis model (2006)
  • Author(s): Masuda H, Maruyama T, Hiratsu E, Ngashima T, Ono M, Okano HJ, Ito M, Tamaoka N, Nomura T, Okano H, Matsuzaki Y, Yoshimura Y
  • Organizer: International Workshop on "Humanized Mice"
  • Place of Presentation: Tokyo,Japan
  • Year and Date: 20061011-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Isolation and functional analysis of human myometrial stem cells. Its potential application as an endometriosis model (2006)
  • Author(s): Ono M, Maruyama T, Masuda H, Kajitani T Uchida H, Nagashim T, Sakurai R, Arase T, Kagami M, Oha K, Ito M, Tamaoki N, Asada H, Yoshimura Y, Okano H, Matsuzaki Y
  • Organizer: International Workshop on "Humanized Mice"
  • Place of Presentation: Tokyo,Japan
  • Year and Date: 20061011-12
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Noninvasive and real-time assessment of reconstructed functional human endometrium in NOD/SCID/gamma(c)(null) immunodeficient mice : Its potential application as an endometriosis model. (2006)
  • Author(s): Masuda, H, Maruyama, T, Hiratsu, E, Ngashima, T, Ono, M, Okano, HJ, Ito, M, Tamaoka, N, Nomura, T, Okano, H, Matsuzaki, Y, Yoshimura, Y
  • Organizer: International Workshop on Humanized Mice
  • Place of Presentation: Tokyo(Japan)
  • Year and Date: 20061011-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Isolation and functional analysis of human myometrial stem cells. Its potential application as an endometriosis model. (2006)
  • Author(s): Ono, M, Maruyama, T, Masuda, H, Kajitani, T, Uchida, H, Nagashim, T, Sakurai, R, Arase, T, Kagami, M, Oha, K, Ito, M, Tamaoki, N, Asada, H, Yoshimura, Y, Okano, H, Matsuzaki, Y
  • Organizer: International Workshop on Humanized Mice
  • Place of Presentation: Tokyo(Japan)
  • Year and Date: 20061011-12
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The relationship between the carbohydrate structures on human trophoblastic stem cells and cell proliferation in early pre enancv (2006)
  • Author(s): Saitoh E, Susumu A, Tanabe K, Yoshimura Y, Aoki D
  • Organizer: The 12th International Federation of Placenta Associations Meetine
  • Place of Presentation: Kobe,Japan
  • Year and Date: 20060910-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The relationship between the carbohydrate structures on human trophoblastic stem cells and cell proliferation in early pregnancy. (2006)
  • Author(s): Saitoh, E, Susumu, A, Tanabe, K, Yoshimura, Y, Aoki, D
  • Organizer: The 12th International Federation of Placenta Associations Meeting
  • Place of Presentation: Kobe(Japan)
  • Year and Date: 20060910-13
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Midkine,a heparin-binding growth factor, suppresses 3-hydroxysteroid dehydrogenase type 2 gene expression in human fetal adrenal cells (2006)
  • Author(s): Ishimoto H, Minegishi K, Higuchi T, Tanaka M, Yoshimura Y, Jaffe RB
  • Organizer: Annual Meeting Steering Committee of The Endocrine Society
  • Place of Presentation: Boston,USA
  • Year and Date: 20060624-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Midkine, a heparin-binding growth factor, suppresses 3-hydroxysteroid dehydrogenase type 2 gene expression in human fetal adrenal cells. (2006)
  • Author(s): Ishimoto, H, Minegishi, K, Higuchi, T, Tanaka, M, Yoshimura, Y, Jaffe, RB
  • Organizer: Annual Meeting Steering Committee of The Endocrine Society
  • Place of Presentation: Boston (USA)
  • Year and Date: 20060624-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression of ubiquitin carboxyl-terminal hydrolasel (UCH-L1) in mouse oocytes and preembryos (2006)
  • Author(s): Kuji N, Yoshida H, Mizusawa Y, Hashaiba T, Asada H, Iwata S, Sueoka K, Yoshimura Y, Kato S, Komatsu S
  • Organizer: 22nd Annual Meeting of the European Society of Human Reproduction and Embryology
  • Place of Presentation: Prague,Czech Republic
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of ubiquitin carboxyl-terminal hydrolasel (UCH-L1) in mouse oocytes and preembryos (2006)
  • Author(s): Kuji N, Yoshida H, Mizusawa Y, Hashaiba T, Asada H, Iwata S, Sueoka K, Yoshimura Y, Kato S, Komatsu S
  • Organizer: Annual Meeting of the European Society of Human Reproduction and Embrvoloev
  • Place of Presentation: Prague,Czech Republic
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] A histone deacetylase inhibitor,SERA, has a potential to enhance implantation through upregulation of glycodelin (2006)
  • Author(s): Uchida H, Maruyama T, Masuda H, Nagashima T, Arasae T, Ono M, Ohta K, Kajitani T, Asada H, Yoshimura Y
  • Organizer: Annual Meeting of the European Society of Human Reproduction and Embryology
  • Place of Presentation: Prague,Czech Republic
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Bromodomain protein BRD4 in mouse oocytes and early embryos its possible involvement in zygotic gene activation and reprogramming of gene expression (2006)
  • Author(s): Nagashima T, Maruyama T, Furuya M, Kajitani T, Masuda H, Uchida H, Arase T, Ono M, Ozato K, Yoshimura Y
  • Organizer: Annual Meeting of the European Society of Human Reproduction and Embrvology
  • Place of Presentation: Prague,Czech Republic
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Histone replacement of injected sperm head after ICSI (2006)
  • Author(s): Mizusawa Y, Kuji N, Tanaka Y, Yoshida H, Hamatani T, Yoshimura Y, Kato S, Komatsu S
  • Organizer: Annual Meeting of the European Society of Human Reproduction and Embryology
  • Place of Presentation: Prague,Czech Republic
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Expression of ubiquitin carboxyl-terminal hydrolasel (UCH-L1) in mouse oocytes and preembryos. (2006)
  • Author(s): Kuji, N, Yoshida, H, Mizusawa, Y, Hashaiba, T, Asada, H, Iwata, S, Sueoka, K, Yoshimura, Y, Kato, S, Komatsu, S
  • Organizer: 22nd Annual Meeting of the European Society of Human Reproduction and Embryology
  • Place of Presentation: Prague, Czech (Republic)
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Expression of ubiquitin carboxyl-terminal hydrolase 1(UCH-L1) in mouse oocytes and preembryos. (2006)
  • Author(s): Kuji, N, Yoshida, H, Mizusawa, Y, Hashiba, T, Asada, H, Iwata, S, Sueoka, K, Yoshimura, Y, Kato, S, Komatsu, S
  • Organizer: Annual Meeting of the European Society of Human Reproduction and Embryology
  • Place of Presentation: Prague (Czech Republic)
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] A histone deacetylase inhibitor, SEHA, has a potential to enhance implantation through upregulationof glycodelin (2006)
  • Author(s): Uchida, H, Maruyama, T, Masuda, H, Nagashima, T, Arasae, T, Ono, M, Ohta, K, Kajitani, T, Asada, H, Yoshimura, Y
  • Organizer: Annual Meeting of the European Society of Human Reproduction and Embryology
  • Place of Presentation: Prague (Czech Republic)
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Bromodomain protein BRD4 in mouse oocytes and early embryos : its possible involvement in zygotic gene activation and reprogramming of gene expression. (2006)
  • Author(s): Nagashima, T, Maruyama, T, Furuya, M, Kajitani, T, Masuda, H, Uchida, H, Arase, T, Ono, M, Ozato, K, Yoshimura, Y
  • Organizer: Annual Meeting of the European Society of Human Reproduction and Embryology
  • Place of Presentation: Prague (Czech Republic)
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Histone replacement of injected sperm head after ICSI. (2006)
  • Author(s): Mizusawa, Y, Kuji, N, Tanaka, Y, Yoshida, H, Hamatani, T, Yoshimura, Y, Kato, S, Komatsu, S
  • Organizer: Annual Meeting of the European Society of Human Reproduction and Embryology
  • Place of Presentation: Prague(Czech Republic)
  • Year and Date: 20060618-21
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Basic consideration of human embryonic mito-chondorial DNA copies for predicting development activities (2006)
  • Author(s): Sakurai T, Sueoka K, Nakabayashi A, Tajima H, Sato K, Watanabe M, Murakoshi Y, Hashiba T, Iwata S. Yoshimura Y
  • Organizer: 13th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 20060528-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] The reliable preimplantation genetic diagnosis (PGD) for Leigh encephalopathy caused by high heteroplasmy ratio of mutant mitochondrial (MT) DNA (2006)
  • Author(s): Tajima H, Sueoka K, Nakabayashi A, Sakurai T, Murakoshi Y, Wanatabe H, Asada H, Iwata S, Hashiba T, Kuii N, Yoshimura Y
  • Organizer: 13th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 20060528-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Improvement of the preimplantation genetic diagnosis efficiency by elective blastomere biopsy (2006)
  • Author(s): Watanabe H, Sueoka K, Nakabayashi A, Tajima H, Sato K, Watanabe M, Murakoshi Y, Hashiba T, Iwata S, Oosawa Y, Matsumoto Y, Moriya S, Yoshimura Y
  • Organizer: 13th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 20060528-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Can Duchenne muscular dystrophy with duplicated exons be diagnosed from a single cell-Newly devised method for preimplantation genetic diagnosis (2006)
  • Author(s): Nakabayashi A, Sueoka K, Watanabe H, Tajima H, Murakoshi Y, Katou S, Yoshimura Y
  • Organizer: 13th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Kyoto,Japan
  • Year and Date: 20060528-31
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Basic consideration of human embryonic mito-chondorial DNA copies for predicting development activities (2006)
  • Author(s): Sakurai, T, Sueoka, K, Nakabayashi, A, Tajima, H, Sato, K, Watanabe, M, Murakoshi, Y, Hashiba, T, Iwata, S, Yoshimura, Y
  • Organizer: 13th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 20060528-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] The reliable preimplantation genetic diagnosis (PGD) for Leigh encephalopathy caused by high heteroplasmy ratio of mutant mitochondrial (MT) DNA (2006)
  • Author(s): Tajima, H, Sueoka, K, Nakabayashi, A, Sakurai, T, Murakoshi, Y, Wanatabe, H, Asada, H, Iwata, S, Hashiba, T, Kuji, N, Yoshimura, Y
  • Organizer: 13th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 20060528-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Improvement of the preimplantation genetic diagnosis efficiency by elective blastomere biopsy. (2006)
  • Author(s): Watanabe, H, Sueoka, K, Nakabayashi, A, Tajima, H, Sato, K, Watanabe, M, Murakoshi, Y, Hashiba, T, Iwata, S, Oosawa, Y, Matsumoto, Y, Moriya, S, Yoshimura, Y
  • Organizer: 13th International Conference on Prenatal Diagnosis and Therapy
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 20060528-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Can Duchenne muscular dystrophy with duplicated exons be diagnosed from a single cell?-Newly devised method for preimplantation genetic diagnosis (2006)
  • Author(s): Nakabayashi, A, Sueoka, K, Watanabe, H, Tajima, H, Murakoshi, Y, Katou, S, Yoshimura, Y
  • Organizer: 13th International Conference on Prenatal Diagnosi
  • Place of Presentation: Kyoto (Japan)
  • Year and Date: 20060528-31
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] AP-1 (c-fos, junB) plays important roles in luteinization and follicle selection after hCG injection to immature rats (2006)
  • Author(s): Nakagawa H, Tanabe K, Hida N, Okazaki M, Sho R, Yoshimura Y
  • Organizer: The 12th World Congress of Gynecological Endocrinology
  • Place of Presentation: Florence,Italy
  • Year and Date: 20060302-05
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] AP-1 (c-fos, junB) plays important roles in luteinization and follicle selection after hCG injection to immature rats (2006)
  • Author(s): Nakagawa, H, Tanabe, K, Hida, N, Okazaki, M, Sho, R, Yoshimura, Y
  • Organizer: The 12th World Congress of Gynecological Endocrinology
  • Place of Presentation: Florence (Italy)
  • Year and Date: 20060302-05
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Bioethical aspect of regenerative medicine and reproductive medicine (2005)
  • Author(s): Yoshimura Y
  • Organizer: 23rd Annual Meeting of Japan Human Cell Society(Publiv Open Symposium)
  • Place of Presentation: Tsukuba,Japan
  • Year and Date: 20050825-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Histone deacetylase inhibitors-induced glycodelin is deeply involved in cytodifferentiation in human endometrial adenocarcinoma cell line, Ishikawa (2005)
  • Author(s): Uchida H, Maruyama T, Sugiura I, Kajitani T, Arase T, Ono M, Nagashima T, Masuda H, Asada H, Yoshimura Y
  • Organizer: 23rd Annual Meeting of Japan Human Cell Society
  • Place of Presentation: Tsukuba,Japan
  • Year and Date: 20050825-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Isolation and identification of putative stem/ progenitor cells from human cycling endometrium (2005)
  • Author(s): Masuda H, Maruyama T, Ono M, Nagashima T, Hamatani T, Okano H, Matsuzaki Y, Yoshimura Y
  • Organizer: 23rd Annual Meeting of Japan Human Cell Society
  • Place of Presentation: Tsukuba,Japan
  • Year and Date: 20050825-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Bioethical aspect of regenerative medicine and reproductive medicine (2005)
  • Author(s): Yoshimura, Y
  • Organizer: 23rd Annual Meeting of Japan Human Cell Society(Publiv Open Symposium)
  • Place of Presentation: Tsukuba (Japan)
  • Year and Date: 20050825-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Histone deacetylase inhibitors-induced glycodelin is deeply involved in cytodifferentiation in human endometrial adenocarcinoma cell line, Ishikawa (2005)
  • Author(s): Uchida, H, Maruyama, T, Sugiura, I, Kajitani, T, Arase, T, Ono, M, Nagashima, T, Masuda, H, Asada, H, Yoshimura, Y
  • Organizer: 23rd Annual Meeting of Japan Human Cell Society
  • Place of Presentation: Tsukuba (Japan)
  • Year and Date: 20050825-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Isolation and identification of putative stem/ progenitor cells from human cycling endometrium (2005)
  • Author(s): Masuda, H, Maruyama, T, Ono, M, Nagashima, T, Hamatani, T, Okano, H, Matsuzaki, Y, Yoshimura, Y
  • Organizer: 23rd Annual Meeting of Japan Human Cell Society
  • Place of Presentation: Tsukuba (Japan)
  • Year and Date: 20050825-27
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Isolation and identification of putative stem/progenitor cells from human cycling endometrium (2005)
  • Author(s): Masuda H, Maruyama T, Ono M, Uchida H, Nagashima T, Ito M, Okano H, Matsuzaki Y, Yoshimura.Y
  • Organizer: The Endocrine Society's 87th Annual Meeting
  • Place of Presentation: San Diego,USA
  • Year and Date: 20050604-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Lack of c-Src tyrosine kinase leads to impairment of ovarian steroid-induced decidualization (2005)
  • Author(s): Maruyama T, Tamaki K, Shimizu A, Uchida H, Nagashima T, Arase T, Ono M, Masuda H, Liu S, Asada H, Yoshimura Y
  • Organizer: The Endocrine Society's 87th Annual Meeting
  • Place of Presentation: San Diego,USA
  • Year and Date: 20050604-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Glycodelin, an endometrial secretory protein, is involved in histone deacetylase inhibitor-induced differentiation and migration of human endometrial adenocarcinoma cells (2005)
  • Author(s): Uchida H, Maruyama T, Nagashima T, Arase T, Ono M, Masuda H, Asada H, Yoshimura Y
  • Organizer: The Endocrine Society's 87th Annual Meeting
  • Place of Presentation: San Diego,USA
  • Year and Date: 20050604-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Isolation and identification of putative stem/progenitor cells from human cycling endometrium (2005)
  • Author(s): Masuda, H, Maruyama, T, Ono, M, Uchida, H, Nagashima, T, Ito, M, Okano, H, Matsuzaki, Y, Yoshimura, Y
  • Organizer: The Endocrine Society's 87th Annual Meeting
  • Place of Presentation: San Diego (USA)
  • Year and Date: 20050604-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Lack of c-Src tyrosine kinase leads to impairment of ovarian steroid-induced decidualization (2005)
  • Author(s): Maruyama, T, Tamaki, K, Shimizu, A, Uchida, H, Nagashima, T, Arase, T, Ono, M, Masuda, H, Liu, S, Asada, H, Yoshimura, Y
  • Organizer: The Endocrine Society's 87th Annual Meeting
  • Place of Presentation: San Diego (USA)
  • Year and Date: 20050604-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Glycodelin, an endometrial secretory protein, is involved in histone deacetylase inhibitor-induced differentiation and migration of human endometrial adenocarcinoma cells (2005)
  • Author(s): Uchida, H, Maruyama, T, Nagashima, T, Arase, T, Ono, M, Masuda, H, Asada, H, Yoshimura, Y
  • Organizer: The Endocrine Society's 87th Annual Meeting
  • Place of Presentation: San Diego (USA)
  • Year and Date: 20050604-07
  • Description: 「研究成果報告書概要(欧文)」より
• [Patent(Industrial Property Rights)] 新規組織幹細胞 (2006)
  • Inventor(s): 丸山 哲夫, 吉村 泰典, 他
  • Industrial Property Rights Holder: 慶応義塾
  • Industrial Property Number: 特願2006-022875
  • Filing Date: 2006-01-31
  • Description: 「研究成果報告書概要(和文)」より
• [Patent(Industrial Property Rights)] 動物モデルとその作成方法 (2006)
  • Inventor(s): 丸山 哲夫, 吉村 泰典, 他
  • Industrial Property Rights Holder: 慶応義塾
  • Industrial Property Number: PCT出願PCT/2006/319415
  • Filing Date: 2006-09-29
  • Description: 「研究成果報告書概要(和文)」より
  • Overseas