2007 Fiscal Year Final Research Report Summary
Development and application of semi-parametric survival analysis for time dependent non-linear prognostic factors
| Project/Area Number |
17300091
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Statistical science
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| Research Institution | Kurume University |
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Principal Investigator |
YANAGAWA Takashi Kurume University, Biostatistics Center, Professor (80029488)
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| Co-Investigator(Kenkyū-buntansha) |
KAKUMA Tatsuyuki Kurume University, Biostatistics Center, Professor (50341540)
MORIKAWA Toshihiko Kurume University, Biostatistics Center, Professor (60425155)
NONAKA Yoshisuke Kurume University, Biostatistics Center, Post Doctoral Fellow (90389320)
YONEMOTO Koji Kyushu University, Graduate School of Medicine, Research Associate (90398090)
HATTORI Satoshi Kurume University, Biostatistics Center, Post Doctoral Fellow (50425154)
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| Project Period (FY) |
2005 – 2007
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| Keywords | survival analysis / time dependent covariate / Spline function / functional analysis of variance / information criterion / repeated measurement / cohort study / stroke |
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| Research Abstract |
1. Considering the situation that (i) the proportional hazard assumption employed in the Cox regression analysis does not hold, (ii) Covariates depend on time and the relationship between survival time and prognostic factors are non-linear, we developed a flexible method of the analysis of survival data based on the following ideas; (a) employed the first order Spline regression function for modeling the relationship of survival time and prognostic factors, (b) introduced tensor product to take into account the interaction of prognostic factors, and c introduced new algorithm for selecting to meaningful interaction terms and knots. Those theoretical problems that are arisen in the development are attacked by investigators under the leadership of the head investigator. The results are published in those papers listed below.
2. We developed a computer program for the new method and applied it to the data from the Hisayama cohort study to explore the relationship between stroke and covari
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ates. It is shown that the risk factors of the stroke that had non-linear relationship with survival time are detected in addition to the known risk factors. Also their risks on the stroke are assessed. Papers demonstrating the usefulness of the method were presented at several international meetings, and a paper submitted for publication, accepted and in press in the Statistics in Medicine.
3. The method above is for the survival data. But it is also useful for studying non-linear relationship of response variable and covariates in non-survival data. To demonstrate it the method was applied to the dada from male junior high school students for elucidate linear and non-linear relationships between reduced visual acuity and its contributing factors including living habits and environment. A paper summarizing the results is submitted for publication in a journal.
4. At least one international conference was held in a year to publicize the results that we obtained and had critical review of our research by world leading scientists. Less
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Research Products
(161 results)
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[Journal Article] Expression of Erlv2/HER2 and estradiol receptor alpha depends upon nuclear localization of Y-box binding protein4(YB-1) in human breast cancers2008
Author(s)
Teruhiko Fujii, Akihiko Kawahara, Yuji Basaki, Satoshi Hattori, Kazutaka Nakashima, Kenji Nakano, Kazuo Shirouzu, Kazuto Nishio, Mayumi Ono, Takashi Yanagawa, Hideaki Yamana, Michihiko Kuwano, and Masayoshi Kage
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Journal Title
Cancer Research 68
Pages: 1504-1512
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Paternal transmission and slow elimination of mutant alleles associated with late-onset ornithine transcarbamylase deficiency in male patients2008
Author(s)
Sanae Numata, Eimei Harada, Yasuki Maeno, Isao Ueki, Yoriko Watanabe, Chieko Fujii, Takashi Yanagawa, Satoshi Takenaka,Toshiro Inoue, Shinkai Inoue, Thrufumi Gousbi, Tsutomu Yasutake, Toshihiko Mizuta and Makoto Yosbino
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Journal Title
Journal of Human Genetics 53
Pages: 10-17
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Incidence of ANCA-associated primary renal vasculitis in the Miyazaki prefecture : the first population-based, retrospective, epidemiologic survey in Japan2006
Author(s)
Fujimoto, Uezono, Hisanaga, Fukudome, Kobayashi, Suzuki, Hashimoto, Nakao, Nunoi
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Journal Title
Clin. J. Am. Soc. Nephrol. 1
Pages: 1016-1022
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] The serum pepsinogen test as a predictor of gastric cancer : the T-Tiqnvama2006
Author(s)
Oishi Y., Kiyohara Y, Kubo M., Tanaka K., Tanizaki Y., Ninomiya T., Doi Y., Shikata K., Yonemoto K., Shirota T., Matsumoto T., Iida M.
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Journal Title
American Journal of Epidemiology 163
Pages: 629-637
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] A prospective study of dietary salt intake and gastric cancer incidence in a defined Japanese population : The Hisayama Study2006
Author(s)
Shikata K., Kiyohara Y., Kubo M., Yonemoto K., Ninomiya T., Shirota T., Tanizaki Y., Doi Y., Tanaka K., Oishi Y., Matsumoto T., Iida M.
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Journal Title
International Journal of Cancer 118
Pages: 196-201
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] C-reactive protein and risk of first-ever ischemic and hemorrhagic stroke in a general Japanese population : the Hisayama Study2006
Author(s)
Wakugawa Y., Kiyohara Y., Tanizaki Y., Kubo M., Ninomiya T., Hata J., Doi Y., Okubo K., Oishi Y, Shikata K., Yonemoto K., aebuchi D., Ibayashi S., Iida M.
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Description
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[Journal Article] Chronic kidney disease and cardiovascular disease in a general Japanese population : the Hisayama Study2005
Author(s)
Ninomiya T., Kiyohara Y., Kubo M., Tanizaki Y., Doi Y., Okubo K, Wakugawa Y., Hata J., Oishi Y., Shikata K., Yonemoto K., Hirakata H., Iida M.
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Journal Title
Diabetes Care 28
Pages: 2497-2500
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Sleep questionare, 1 week sleep diaries and actigraphy studiesin Japan2007
Author(s)
Matsuishi Toyojiro, Iwasaki, Mizue, Yamashita Natsumi, Iemura, Akiko Ohya Takashi, Yanagawa Takashi
Organizer
Third Annual Pediatric Sleep Medicine Conference
Place of Presentation
Amelia, Island, Florida, USA
Year and Date
2007-03-17
Description
「研究成果報告書概要(欧文)」より
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[Book] ハリエットレーンハンドブック2007
Author(s)
柳川 尭(バイオ統計学とEBM項目の翻訳)
Total Pages
942
Publisher
メディカルサイエンス・インターナショナル
Description
「研究成果報告書概要(和文)」より
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