2007 Fiscal Year Final Research Report Summary
Mechanisms of Layer Formation of Cerebral Neocortex and Layer-specific Neural Circuits
| Project/Area Number |
17300111
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Nerve anatomy/Neuropathology
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| Research Institution | Kobe University |
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Principal Investigator |
TERASHIMA Toshio Kobe University, Graduate School of Medicine, Professor (20101892)
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| Co-Investigator(Kenkyū-buntansha) |
KIKKAWA Satoshi Kobe University, Graduate School of Medicine, Assistant Professor (90244681)
KATSUYAMA Yu Kobe University, Graduate School of Medicine, Assistant Professor (10359862)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Reelin / Cerebral Cortex / Layer Structure / Reeler |
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| Research Abstract |
Reeler and yotari mice that are mutant for Reelin or Dab1, respectively, show disorders of cerebral cortical lamination. We injected horseradish peroxidase (HRP)into the upper lumbar enlargement to label corticospinal tract (CST) neurons and wheat germ agglutinin-conjugated HRP (WGA-HRP) into the ventrolateral nucleus of the thalamus to label corticothalamic tract (CTT) neurons in both 19-day-old yotari and reeler mice with the aim of discovering whether or not they show differences in the distribution pattern of layer V or layer VI neurons. Similar injections of tracers were made in normal controls. HRP-labeled CST neurons, which were exclusively distributed in the layer V of the normal cortex, were radially scattered in the cortex of both mutants, but those in reeler were more deeply distributed than in yotari. WGA-labeled CTT neurons, which were mainly located in layer VI in the normal cortex, were superficially distributed just beneath the pia mater in both reeler and yotari cortex. The present quantitative study shows that the distribution pattern of layer V neurons, but not layer VI neurons, differs between reeler and yotari mice, suggesting that the Reelin and Dab1 proteins may play different roles in the migration and cell positioning of layer V neurons.
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Research Products
(10 results)
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[Journal Article] Expression o zebrafish ROR alpha gene in cerebellar-like structures2007
Author(s)
Katsuyama, Y., Oomiya, Y., Dekimoto, H., Motooka, E., Takani, A., Kikkawa, S., Hibi, M., Terashima, T
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Journal Title
Dev Dyn. 236
Pages: 2694-2701
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Origin c climbing fiber neurons and their developments dependence on Ptf1a2007
Author(s)
Yamada, M., Terao, M., Terashima, T., Fujiyama, T., Kawaguchi, Y., Nabeshima, Y., Hoshino, M
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Journal Title
J Neurosci 27(41)
Pages: 10924-10934
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Defective vascular morphogenesis and mid-gestati embryonic death in mice lacking RA-GEF2007
Author(s)
Wei, P., Satoh, T., Edamatsu, H., Aiba, A., Setsu, T., Terashima Kitazawa, S., Nakao, K., Yoshikawa, Y., Tamada, M., Kataoka
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Journal Title
Biochem Biophys Res Commun 363(1)
Pages: 106-112
Description
「研究成果報告書概要(欧文)」より
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