2007 Fiscal Year Final Research Report Summary
Development of Radiography Using Proton-Induced X-Rays to Reduce the Dosages of Contrast-Medium and Radiation
| Project/Area Number |
17300170
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Medical systems
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| Research Institution | Tokyo Institute of Technology |
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Principal Investigator |
OGURI Yoshiyuki Tokyo Institute of Technology, Research Laboratory for Nuclear Reactors, Associate Professor (90160829)
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| Co-Investigator(Kenkyū-buntansha) |
HASEGAWA Jun Tokyo Institute of Technology, Research Laboratory for Nuclear Reactors, Assistant Professor (90302984)
OGAWA Masao Komazawa University, Faculty of Health Sciences, Professor (60016863)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Angiography / Iodinated contrast medium / Exposure dose / K-absorption edge / Proton-induced X-ray emission / Characteristic X-ray / Micro ion beam / Glass micro capillary |
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| Research Abstract |
Characteristic-line radiation from heavy metal targets bombarded by MeV proton beams has been tested as an X-ray source for angiography based on iodinated contrast media. To utilize the strong absorption by iodine (Z=53) at its K-absorption edge (33.2 keV), we used K-alpha line of La (lanthanum, Z=57) at 33.4 keV. As a reference, also K-alpha emission of Sn (tin, Z =50) at 25.2 keV was employed. Metallic plates of La and Sn were irradiated by 7-MeV protons to produce these X-rays. Dual-energy K-edge subtraction method was tested using Lucite phantoms which contain aqueous solutions of potassium iodide. Also Calcium compound was stuffed in these phantoms to simulate bones. The transmission images of the phantoms were recorded on imaging plates. We found that the contrast of images of iodide solutions taken with La X-rays was higher than that with Sn X-rays. Also the energy subtraction procedure was successfully applied to reduce the graphical noise due to the bones and inhomogeneity of the soft tissue. However, for actual clinical use, the X-ray intensity must be increased by several orders of magnitude.
To increase spatial resolution of images, we constructed a compact proton micro-beam system using a tapered glass capillary tube with a tip diameter on the order of 10 microns. The transport efficiency of 2-3-MeV protons through the capillary was examined as a function of the capillary tilt angle and the tip diameter. We obtained transport efficiencies of approximately three times larger than would be expected from the geometrical shape of the capillary. A metallic thin foil was irradiated with the micro beam and quasi-monochromatic X-rays were produced. We demonstrated magnification radiography of a small object to show that a spatial resolution on the order of 10 microns was achievable in our system.
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Research Products
(26 results)
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[Presentation] Quality Evaluation of MeV-Proton Beam Focused with a Glass Capillary2007
Author(s)
Shigeki, Shiba, Jun, Hasegawa, Hitoshi, Fukuda, Yoshiyuki, Oguri
Organizer
The 62th Meeting of the Physical Society of Japan
Place of Presentation
Sapporo campus, Hokkaido University, Hokkaido, Japan
Year and Date
2007-09-21
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Generation of Micro Proton Beam Using a Glass Capillary and Its Application to X-ray Imaging2007
Author(s)
Jun, Hasegawa, Shigeki, Shiba, Hitoshi, Fukuda, Yoshiyuki, Oguri, Masao, Ogawa
Organizer
2007 Annual Meeting of the Atomic Energy Society of Japan
Place of Presentation
Nagoya University, Nagoya, Japan
Year and Date
2007-03-28
Description
「研究成果報告書概要(欧文)」より
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[Presentation] A Phantom Test on Dual-Energy Angiography Using Iodinated Contrast Agent and Proton-Induced Characteristic X-rays2006
Author(s)
Yoshiyuki, Oguri, Jun, Hasegawa, Masao, Ogawa, Jun-ichi, Kaneko, Kimikazu, Sasa
Organizer
The 23th PIXE Symposium
Place of Presentation
Hotel Matsushima-Taikanso, Miyagi, Japan
Year and Date
2006-11-15
Description
「研究成果報告書概要(欧文)」より
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