2007 Fiscal Year Final Research Report Summary
Research on Terahertz Spectroscopy far Biomolecules
| Project/Area Number |
17360030
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Applied optics/Quantum optical engineering
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
TANI Masahiko Osaka University, Institute of Laser Engineering, Professor (00346181)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
KITAHARA Hideaki Osaka University, Institute of Lasar Engineering, Researcher (20397649)
SHIBUYA Kyoji Osaka University, Institute of Laser Engineering, Researcher (60403036)
|
|---|
| Project Period (FY) |
2005 – 2007
|
| Keywords | Terahertz / Biomolecules / Light Source / Applied Optics / Vibrational Circular Dichroism / 振動円偏光二色性分光 |
|---|
| Research Abstract |
The objective of this research is development of novel devices and techniques for spectroscopic investigation of biomolecular dynamics in the teraherlz (THz) frequency region. Specifically, we focused our efforts on the realization of vibrational circular dichroism (VCD) spectroscopy, which makes use of the polarization properties of molecules, in the THz frequency region. Our achievements are categorized into threefold: (1) Development of THz radiation sources, (2) Development of THz radiation detectors, and (3) Measurements of biomolecules based on the THz time-domain spectroscopy (THz-TDS). As for the THz source and detector we developed four- and three-contacts photoconductive antennas, each proved to be capable of high-frequency modulation of the polarization and high-precision measurement of the polarization vector for THz pulsed radiation, respectively. These devices are useful for the VCD spectroscopy in the THz region. As for the measurement of biomolecules, we measured THz sp
… More
ectra of basic and simple biomolecules, such as amino acids. Many spectral data were accumulated. We observed differences between THz spectra of racemic compounds (consisted of DL dimers) and their enantiomer (D or L monomers), such as for alanine and tartaric acid. It was proved that analyses using the multiple regression are useful for quantitative evaluation of those mixtures. We constructed a highly polarization sensitive THz-TDS system for measurements of VCD spectra in THz frequency region, with which a birefringence as low as 10^<-5>is detectable. With this system we measured an amino-acid ionic liquid ([TBP][L/D-Ala]), which was expected to have vibrational modes in the THz frequency region and to exhibit the VCD signal associated with them. The VCD signal of the ionic liquid was proved to be less than 10^<-5> but the VCD signal in the THz frequency region was not confirmed within the experimental errors.
These devices and techniques developed in this research project are considered to be quite useful for future spectroscopic researches, such as the VCD spectroscopy, on organic and biological molecules in the THz frequency region. Less
|
-
[Journal Article] Application of Partial Least Square on Quantitative Analysis of L-, D-, and DL-Tartaric Acid by Terahertz Absorption Spectra2008
Author(s)
Rika Nishikiori, Mariko Yamaguchi, Keisuke Takano, Tokujiro Enatsu, Masahiko Tani, U. Chandimal de Silva, Norihito Kawashita, Tatsuya Takagi, Shotaro Morimoto, Masanori Hangyo, and Masaya Kawase
-
Journal Title
Chem. Pharm. Bull. 56
Pages: 305-307
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
-
[Journal Article] Application of Partial Least Square on Quantitative Analysis of L-, D-, and DL-Tartaric Acid by Terahertz Absorption Spectra2008
Author(s)
Rika, Nishikiori, Mariko, Yamaguchi, Keisuke, Takano, Tokujiro, Enatsu, Masahiko, Tani, U., Chandimal, de, Silva, Norihito, Kawashita, Tatsuya, Takagi, Shotaro, Morimoto, Masanori, Hangyo, Masaya, Kawase
-
Journal Title
Chem. Pharm. Bull 56
Pages: 305-307
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Applications of Terahertz Spectroscopy and Imaging to Medical and Bio Science(In Japanese)2008
Author(s)
Masahiko, Tani, Mariko, Yamaguchi, Kohji, Yamamoto, Tokujiro, Enatsu, Hideaki, Kitahara, Masanori, Hangyo, Yasuhiro, Miura, Takashi, Sawai
-
Journal Title
Journal of Japan Society for Laser Surgery and Mpdieinp(レーザー医学会誌) 28
Pages: 395-403
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Journal Article] テラヘルツ時間領域分光の応用2007
Author(s)
谷 正彦, 山口 真理子, 山本 晃司, 廣田 裕一, 萩行 正憲
-
Journal Title
月刊オプトロニクス 8月号:特集「テラヘルツ分光・イメージングの計測への応用」 No.308
Pages: 102-109
Description
「研究成果報告書概要(和文)」より
-
-
-
-
-
[Journal Article] Applications of Terahertz Time-Domain Spectroscopy(In Japanese)2007
Author(s)
Masahiko, Tani, Mariko, Yamaguchi, Kohji, Yamamoto, Yuichi, Hirota, Masanori, Hangyo
-
Journal Title
OPTRONICS, Issue in August(月刊オプトロニクス8月特集号) 308
Pages: 102-109
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Emission of THz Radiation from Semiconductor Surfaces(In Japanese)2007
Author(s)
Masahiko, Tani, Pin, Gu, Masanori, Hangyo, Kiyomi, Sakai
-
Journal Title
Handbook on Surface Property Engineering, 2nd Edition, Eds., A. Ono, et. al. 7, 10
Pages: 460-465
Description
「研究成果報告書概要(欧文)」より
-
-
[Journal Article] Terahertz Time-Domain Spectroscopy(In Japanese)2007
Author(s)
Masahiko, Tani, Mariko, Yamaguchi, Kohji, Yamamoto, Takeshi, Nagashima, Shuji, Matsuura, Masanori, Hangyo
-
Journal Title
Terahertz Technology Handbook,Terahertz Technology Forum 7.2.3
Pages: 406-419
Description
「研究成果報告書概要(欧文)」より
-
[Journal Article] Novel terahertz photoconductive antennas2006
Author(s)
Masahiko Tani, Yuichi Hirota, Christopher T. Que, Shigehisa Tanaka, Ryo Hattori, Mariko Yamaguchi, Seizi Nishizawa, and Masanori Hangyo
-
Journal Title
International Journal of Infrared and Millimeter Waves 27
Pages: 531-546
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
-
-
-
[Journal Article] Novel terahertz photoconductive antennas2006
Author(s)
Masahiko, Tani, Yuichi, Hirota, Christopher, T., Que, Shigehisa, Tanaka, Ryo, Hattori, Mariko, Yamaguchi, Seizi, Nishizawa, Masanori, Hangyo
-
Journal Title
International Journal of Infrared and Millimeter Waves 27
Pages: 531-546
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
[Journal Article] Terahertz absorption spectra of L-, D-, and DL-alanine and their application to determination of enantiometric composition2005
Author(s)
Mariko, Yamaguchi, Fumiaki, Miyamaru, Kohji, Yamamoto, Masahiko, Tani, Masanori, Hangyo
-
Journal Title
Appl. Phys. Lett 86
Pages: 053903(1)-3053903(3)
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Presentation] An Overview of Terahertz Spectroscopy(In Japanese)2008
Author(s)
Masahiko, Tani
Organizer
Feasibility of Low-Frequency Spectroscopy for Bio-Molecules and Polymers-From THz to Microwaves-, Symposium of The 55th Spring Meeting, 2008, The Japan Society of Applied Physics(2008年春季第55回応用物理学関係連合講演会,日本分光学会THz分光部会・応用物理学会THz電磁波技術研究会合同企画「低振動数領域での生体・高分子分光の可能性〜テラヘルツからマイクロ波まで〜」) 27p-ZH-3
Place of Presentation
College of Science and Technology, Nihon University, Funahashi Campus Furashi, Japan
Year and Date
2008-03-27
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Presentation] Recent Developments in Terahertz Spectroscopy2007
Author(s)
M. Tani, C. Tan Que, H. Makabe, S. Ebara, and M Hangyo
Organizer
The 25th SPP(The Samahang Pisika ng Pilipinas)Physics Congress
Place of Presentation
University of Philippines, Los Banos, Laguna, Philippines
Year and Date
20071024-26
Description
「研究成果報告書概要(和文)」より
-
[Presentation] Recent Developments in Terahertz Spectroscopy2007
Author(s)
M., Tani, C., Tan, Que, H., Makabe, S., Ebara, M, Hangyo
Organizer
The 25th SPP(The Samahang Pisika ng Pilipinas) Physics Congress
Place of Presentation
University of Philippines, Los Banos, Laguna, Philippines
Year and Date
20071024-26
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
-
[Presentation] Medical application of THz tomography2007
Author(s)
H. Kitahara, K. Takano, M. Tani and M. Hangyo
Organizer
Topical Problems of Biophotonics-2007(TPB2007), Paper No.5-15
Place of Presentation
Nizhiny Novgorod-Moscow, Russia
Year and Date
20070804-11
Description
「研究成果報告書概要(和文)」より
-
-
-
-
[Presentation] Measurement of Polarization States of THz radiation Using Three-Contacts Photoconductive Antenna(In Japanese)2007
Author(s)
Hiroyuki, Makabe, Yuichi, Hirota, Masahiko, Tani, Masanori, Hangyo
Organizer
The 54th Spring Meeting, 2007, The Japan Society of Applied Physics(2007年春季第54回応用物理学関係連合講演会) 29p-J-13
Place of Presentation
Sagamihara Campus, Aoyama Gakuin University, Sagamihara, Japan
Year and Date
20070327-30
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Enhanced Efficiency of THz Photomixing Emission Using a Multi-Mode LD Operated in Pulsed-Mode(In Japanese)2007
Author(s)
Kyoji, Shibuya, Masahiko, Tani, Masanori, Hangyo, Toru, Nakajima, Takashi, Inoue, Kenji, Wada, Hiroshi, Takamatsu, Hideyuki, Watanabe, Hiromichi, Horinaka
Organizer
The 54th Spring Meeting, 2007, The Japan Society of Applied Physics(2007年春季第54回応用物理学関係連合講演会) 305-J-3
Place of Presentation
Sagamihara Campus, Aoyama Gakuin University, Sagamihara, Japan
Year and Date
20070327-30
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Absorption Spectroscopy and Imaging in THz Frequency Region(In Japanese)2007
Author(s)
Masahiko, Tani, Mariko, Yamaguchi, Masanori, Hangyo
Organizer
Vibrational Spectroscopy for Expoiring the Signature of Biological Functions, Symposium of The 54th Spring Meeting, 2007, The Japan Society of Applied Physics(2007年春季第54回応用物理学関係連合講演会 シンポジウム「振動分光で探る生体機能のシグネチャー」) 29p-R-4
Place of Presentation
Sagamihara Campus, Aoyama Gakuin University, Sagamihara, Japan
Year and Date
20070327-30
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Presentation] Measurement of Amino-Acid Ionic Liquid with Terahertz Time-Domain Spectroscopy(In Japanese)2007
Author(s)
Hiroyuki, Makabe, Kohji, Yamamoto, Masahiko, Tani, Masanori, Hangyo, Hiroyuki, Ohno
Organizer
The Second Symposium on Ionic Liquid Science, 2007(「イオン液体の科学」平成19年度第2回公開シンポジウム)
Place of Presentation
Ishikawa Ongakudo, Kanazawa, Japan
Year and Date
2007-12-27
Description
「研究成果報告書概要(欧文)」より
-
-
[Presentation] Spectroscopic and Measurement Applications with THz Pulsed Radiation(In Japanese)2007
Author(s)
Masahiko, Tani, Takeshi, Nagashima, Hideaki, Kitahara, Kohji, Yamamoto, Mariko, Yamaguchi, Masanori, Hangyo
Organizer
The Second Workshop of EMAP, 2007(第2回EMAP研究会)
Place of Presentation
Joining and Welding Research Institute, Osaka University, Suita, Japan
Year and Date
2007-12-15
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Presentation] Generation of Terahertz Radiation and Spectroscopic Techniques Using Femtosecond Lasers(In Japanese)2007
Author(s)
Masahiko, Tani, Takeshi, Nagashima, Masanori, Hangyo
Organizer
Symposium on Recent Trend in Terahertz Wave Technology-Growing Expectation for Applications-, Optics & Photonics Japan 2007(OPJ2007シンポジウム「テラヘルツ波技術の最新動向-高まる応用への期待-」)
Place of Presentation
Osaka University Convention Center, Suita Campus, Osaka University, Suita, Japan
Year and Date
2007-11-27
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Presentation] テラヘルツ電磁波の時間領域高精度偏光検出2006
Author(s)
廣田裕一, 江原真一郎, 谷正彦, 萩行正憲
Organizer
日本赤外線学会 平成18年度 研究発表会
Place of Presentation
大阪大学レーザーエネルギー学研究センター,吹田市
Year and Date
20061130-1201
Description
「研究成果報告書概要(和文)」より
-
[Presentation] Enhanced Photomixing Efficiency Using a Multi-Mode LD(In Japanese)2006
Author(s)
Kyoji, Shibuya, Masahiko, Tani, Masanori, Hangyo, Tbru, Nakajima, Takashi, Inoue, Kenji, Wada, Hiroshi, Takamatsu, Hideyuki, Watanabe, Hiromichi, Horinaka
Organizer
2006 Conference of The Japan Society of Infrared Science and Technology(平成18年度日本赤外線学会研究発表会)
Place of Presentation
Institute of Laser Engineering, Osaka University, Suita, Japan
Year and Date
20061130-1201
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Time-Domain, High Precision Detection of Polarization of THz Radiation(In Japanese)2006
Author(s)
Yuichi, Hirota, Shin-ichiro, Ebara, Masahiko, Tani, Masanori, Hangyo
Organizer
2006 Conference of The Japan Society of Infrared Science and Technoloev(平成18年度日本赤外線学会研究発表会)
Place of Presentation
Institute of Laser Engineering, Osaka University, Suita, Japan
Year and Date
20061130-1201
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Presentation] Time-Domain, High Precision Detection of Polarization of THz Radiation(In Japanese)2006
Author(s)
Yuichi, Hirota, Masahiko, Tani, Masanori Hangyo
Organizer
Symposium on The Frontier of THz Spectroscopy-What is visible and invisible with THz Spectroscopy-, The Division of THz Spectroscopy, The Spectroscopical Society of Japan(日本分光学会テラヘルツ光部会シンポジウム「テラヘルツ分光の最先端-テラヘルツ分光で見えるもの見えないもの-」) P-7
Place of Presentation
International Productivity Center, Hayama-cho, Kanagawa, Japan
Year and Date
20061102-03
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Presentation] Study on the Low-Energy Spectra of Liquids and Proteins with Terahertz -Time-Domain Spectroscopy(In Japanese)2006
Author(s)
Kohji, Yamamoto, Mariko, Yamaguchi, Masahiko, Tani, Masanori, Hangyo
Organizer
Symposium on Dynamics and Optical Scattering in THz Frequency Region, The Physical Society of Japan 2006 Autumn Meeting(日本物理学会2006年秋季大会 シンポジウム「THz関連領域のダイナミクスと光散乱」) 25pRCO3
Place of Presentation
Nishi-Chiba Campus, Chiba University, Chiba, Japan
Year and Date
20060923-26
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
[Presentation] Difference Between Poly-Peptides and Proteins Observed in Low-Frequency Spectra(In Japanese)2006
Author(s)
Mariko, Yamaguchi, Kohji, Yamamoto, Masahiko, Tani, Masanori, Hangyo
Organizer
Workshop On Protein Dynamics(蛋白質ダイナミクス研究会)
Place of Presentation
School of Medicine, Gifu University, Gifu, Japan
Year and Date
20060622-23
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
[Presentation] Comparison between a dynamic structure factor in inelastic neutron scattering and a terahertz spectrum2006
Author(s)
M., Yamaguchi, K., Yamamoto, K, Tani, M., Hangyo
Organizer
The 3rd Open Workshop Chemistry of Biological Processes Created by Water and Biomolecules(第3回「水と生体分子」公開ワークショップ)(P057)
Place of Presentation
Okazaki Conference Center, National Institute of Natural Sciences, Okazaki, Japan
Year and Date
20060106-07
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
[Presentation] Imaging and Non-Destructive Measurements Applications Using THz Pulsed Radiation(In Japanese)2006
Author(s)
Masahiko, Tani, Hideaki, Kitahara, Kohji, Yamamoto, Masanori, Hangyo
Organizer
Laser Imaging and Micro-Optics, The 102nd Workshop of Micro-Optics, The Micro -Optics Group, Optical Society of Japan. The Japan Society of Applied Physics(応用物理学会日本光学会微小光学研究グループ第102回微小光学研究会 レーザーイメージングと微小光学)
Place of Presentation
Alumnus Union Building of Osaka University Medical School, Suita Campus, Osaka University, Suita, Japan
Year and Date
2006-12-01
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
-
-
[Presentation] Optical-Fiber-Coupled Sub-Terahertz System with CW-MLD(In Japanese)2005
Author(s)
Kyoji, Shibuya, Osamu, Morikawa, Fumiaki, Miyamaru, Kazuyoshi, Muto, Masahiko, Tani, Masanori, Hangyo
Organizer
2005 Conference of The Japan Society of Infrared Science and Technology(平成17年度 日本赤外線学会研究発表会)
Place of Presentation
Chubu University, Kasugai, Japan
Year and Date
20051027-28
Description
「研究成果報告書概要(欧文)」より
-
-
[Presentation] Terahertz spectroscopy of short peptides2005
Author(s)
M. Yamaguchi, K. Yamamoto, M. Tarsi, and M. Hangyo
Organizer
The Joint 30th International Conference on Infrared and Millimeter Waves & 13th International Conference on Terahertz Electronics(IRMMW-THz2005), Paper No. WB3-3
Place of Presentation
Williamsburg, Virginia, USA
Year and Date
20050919-23
Description
「研究成果報告書概要(和文)」より
-
[Presentation] Terahertz spectroscopy of short peptides2005
Author(s)
M., Yamaguchi, K., Yamamoto, M., Tani, M., Hangyo
Organizer
The Joint 30th International Conference on Infrared and Millimeter Waves & 13th International Conference on Terahertz Electronics(IRMMW-THz2005), Paper No.WB3-3
Place of Presentation
Williamsburg, Virginia, USA
Year and Date
20050919-23
Description
「研究成果報告書概要(欧文)」より
-
-
[Presentation] Terahertz Spectroscopy of Lysozyme(In Japanese)2005
Author(s)
Mariko, Yamaguchi, Kohji, Yamamoto, Masahiko, Tani, Masanori, Hangyo
Organizer
The 66th Autumn Meeting, 2005, The Japan Society of Applied Physics(2005年 秋季第66回応用物理学会学術講演会)9a-P6-40
Place of Presentation
Mishima Campus, The University of Tokushima, Tokushima, Japan
Year and Date
20050907-11
Description
「研究成果報告書概要(欧文)」より
-
[Presentation] Rectification effect on THz photoconductive antennas2005
Author(s)
M. Tani, F. Miyamaru, C. Que, and M. Hangyo
Organizer
International Quantum Electronics Conference 2005 and the the Pacific Rim Conference on Lasers and Electro-Optics 2005 (IQEC/CLEO-PR 2005), Paper No. JFH1-4
Place of Presentation
Tokyo, Japan
Year and Date
20050711-15
Description
「研究成果報告書概要(和文)」より
-
-
[Presentation] Rectification effect on THz photoconductive antennas2005
Author(s)
M., Tani, F., Miyamaru, C., Que, M., Hangyo
Organizer
International Quantum Electronics Conference 2005 and the Pacific Rim Conference on Lasers and Electro-Optics 2005(1QEC/CLEO-PR 2005), Paper No.JFH1-4
Place of Presentation
Tokyo, Japan
Year and Date
20050711-15
Description
「研究成果報告書概要(欧文)」より
-
-
-
-
-
[Presentation] An Overview of Terahertz Spectroscopy(In Japanese)2005
Author(s)
Masahiko, Tani
Organizer
Seminar on Terahertz and Far Infrared Spectroscopy by The Division of Terahertz Spectroscopy, The Spectroscopical Society of Japan(テラヘルツ・遠赤外分光法入門講習会((社)日本分光学会 テラヘルツ分光部会・高分解能分子分光部会主催,2005分析展同時開催)
Place of Presentation
International Conference Hall, Makuhari Messe, Chiba, Japan
Year and Date
2005-09-01
Description
「研究成果報告書概要(欧文)」より
-
-
-
[Book] 半導体表面からのテラヘルツ電磁波放射"「表面物性工学ハンドブック第2版」10章7節2007
Author(s)
谷正彦, 顧萍, 萩行正憲, 阪井清美
Total Pages
460-465
Publisher
小間篤,青野正和,石橋幸治,塚田捷,常行真司,長谷川修司,八木克道,吉信淳 編,丸善
Description
「研究成果報告書概要(和文)」より
-
-
-
-
-
