STUDIES OF THE OVERCOME FOR PSYCHOSOMATIC STRESS AND REGULATION OF EMOTION BY FOOD COMPONENTS

2006 Fiscal Year Final Research Report Summary

• Project/Area Number: 17380083
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Food science
• Research Institution: THE UNIVERSITY OF SHIZUOKA
• Principal Investigator: YOKOGOSHI Hidehiko THE UNIVERSITY OF SHIZUOKA, LAB.OF NUTR.BIOCHEM., SCHOOL OF FOOD AND NUTR.SCI., PROFESSOR, 食品栄養科学部, 教授 (70109320)
• Co-Investigator(Kenkyū-buntansha): SHIMBO Mari THE UNIVERSITY OF SHIZUOKA, SCHOOL OF FOOD AND NUTR.SCI., INSTRUCTOR, 健康医療福祉学部, 講師 (20300139) ; TERASHIMA Takehiko HAMAMATSU UNIV., DEP/OF HEALTH PRODUCING, INSTRUCTOR, 健康プロデュース学部, 助手 ; HAYASE Kazutoshi AICHI UNIV.OF EDUCATION, DEP.HOME ECONOMICS, PROF., 教育学部, 教授 (10144180)
• Project Period (FY): 2005 – 2006
• Keywords: STRESS / ANALYSIS OF EMOTION / SEROTONIN / CHROMOGRANIN A / M.AITCHISONII / GABA / LEMON OIL / THEANINE

Research Abstract

Until now, we examined the effect of some food components on brain neurotransmitters and some kinds of behavior by using cell culture Iin vitro), perfusion of tissue slices, animals (in vivo) and human subjects, and the anti-stressful action of food components. Then we demonstrated that theanine, one of the main components in green tea extract, and r-aminobutyric acid (GABA) showed the anti-stressful effect in animals and subjects. Also some odor components such as limonene, terpenene or pinene in lemon essential oil showed to induce the relaxation. For example, theanine induce the release of dopamine, one of the neurotransmitters, in striatum. Therefore, we examined the mechanism of the regulation of neurotransmitters in brain, especially striatum, by using the superfusion method or brain microdialysis.
1.Studies of theanine on neuronal regulation
Theanine stimulates the dopamine release from the striatum. Then several kinds of antagonist of glutaminergic, GABAergic, or glycinergic receptors were used to study the effect of theanine on dopamine release. We demonstrated the changes of suppressive Internet Explorer-ink neurotransmitters, such as glycine and GABA, after the administration of theanine. Internet Explorer.lnk
2. Studies of lemon essential oil on neuronal regulation
Lemon essential oil containing limonene or terpinene affects some kinds of neurotransmitters. Also these components showed the anti-stressful effect by using communication box.
3. Studies of Mycoleptodonoides aitchisonii on neuronal regulation
4. Studies of GABA on neuronal regulation
For human studies, we demonstrated the anti-stressful effect of GABA under the mathematical stress by determining the salivary chromoglanin A.

Research Products

• [Journal Article] Effect of ovary lipid of skipjack tuna on rat serum components after stress application. (2007)
  • Author(s): Ookawa, K, Mochizuki, K, Sugimoto, Y, Suzuki, T, Hashizume, M, Kitagawa, T, Matumoto, T, Ito, C, Yokogoshi, H
  • Journal Title: J. Vet. Med. Sci. 69・1 Pages: 49-54
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] The role of growth hormone and amino acids on brain protein synthesis in aged rats given proteins of different quantity and quality. (2007)
  • Author(s): Ohsumi, M, Shi, X, Tuchiya, T, Tujioka, K, Lyou, S, Hayase, K, Yokogoshi, H
  • Journal Title: Amino Acids 32・2 Pages: 247-253
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Dietary gamma-aminobutyric acid affects the brain protein synthesis rate in young rats. (2007)
  • Author(s): Tujioka, K, Okuyama, S, Yokogoshi, H, Fukaya, Y, Hayase, K, Horie, K, Kim, M
  • Journal Title: Amino Acids 32・2 Pages: 255-260
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of ovary lipids of skipjack tuna (Katsuwonus pelamis) on gastric injury in rats subject to water immersion restraint stress. (2007)
  • Author(s): Ookawa, K, Mochizuki, K, Sugimoto, Y, Suzuki, T, Hashidume, M, Kitagawa, T, Matumoto, T, Yokogoshi, H
  • Journal Title: J. Jpn. Soc. Food Sci. Technol.-Nippon Shokuhin Kagaku Kogaku Kaishi. 53・5 Pages: 305-307
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of ovary lipid of skipjack tuna on rat serum components after stress application. (2007)
  • Author(s): Ookawa, K, Mochizuki, K, Sugimoto, Y, Suzuki, T, Hashizume, M, Kitagawa, T, Matumoto, T, Ito, C, Yokogoshi, H
  • Journal Title: J Vet.Med.Sci. 69(1) Pages: 49-54
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] The role of growth hormone and amino acids on brain protein synthesis in aged rats given proteins of different quantity and quality. (2007)
  • Author(s): Ohsumi, M, Shi, X, Tuchiya, T, Tujioka, K, Lyou, S, Hayase, K, Yokogoshi, H
  • Journal Title: Amino Acids 32(2) Pages: 247-253
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Dietary gamma-aminobutyric acid affects the brain protein synthesis rate in young rats. (2007)
  • Author(s): Tujioka, K, Okuyama, S, Yokogoshi, H, Fukaya, Y, Hayase, K, Horie, K, Kim, M
  • Journal Title: Amino Acids 32(2) Pages: 255-260
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of ovary lipid of skipjack tuna on rat serum components after stress application. (2007)
  • Author(s): Ookawa, K, Mochizuki, K, Sugimoto, Y, Suzuki, T, Hashizume, M, Kitagawa, T, Matumoto, T, Ito, C; Yokogoshi, H.
  • Journal Title: J Vet.Med.Sci. 69・1 Pages: 247-253
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Glutamate reduces secretion of 1-serine in astrocytes isolated from stroke-prone spontaneously hypertensive rats. (2006)
  • Author(s): Yamagata, K., Shoji, Y., Terashima, T., Yokogoshi, H.
  • Journal Title: Neuroscience 143・3 Pages: 729-737
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1. (2006)
  • Author(s): Morita, A., Iwasaki, Y., Kobata, K., Iida, T., Higashi, T., Oda, K., Suzuki, A., Narukawa, M., Sasakuma, S., Yokogoshi, H., Yazawa, S., Tominaga, M., Watanabe, T.
  • Journal Title: Life Sciences 79・24 Pages: 2303-2310
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Relaxation and immunity enhancement effects of ホウ-Aminobutyric acid (GABA) administration in humans. (2006)
  • Author(s): Abdou, A.M., Higashiguchi, S., Horie, K., Kim, M., Hatta, H., Yokogoshi, H.
  • Journal Title: BioFactors 26・3 Pages: 201-208
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Effect of ovary lipids of skipjack tuna (Katsuwonus pelamis) on gastric injury in rats subject to water immersion restraint stress. (2006)
  • Author(s): Ookawa, K., Mochizuki, K., Sugimoto, Y., Suzuki, T., Hashidume, M., Yitagawa, T., Matumoto, T., Yokogoshi, H.
  • Journal Title: Nippon Shokuhin Kagaku Kogaku Kaishi 53・5 Pages: 305-307
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Flavor components of monoterpenes in citrus essential oils enhance the release of monoamines from rat brain slices. (2006)
  • Author(s): Fukumoto, S., Sawasaki, E., Okuyama, S., Miyake, Y., Yokogoshi, H.
  • Journal Title: Nutritional Neuroscience 9・1-2 Pages: 73-80
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells. (2006)
  • Author(s): Lam, N.V., Chen, W., Suruga, K., Nishimura, N., Goda, T., Yokogoshi, H
  • Journal Title: Amino Acids 30・1 Pages: 43-48
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Glutamate reduces secretion of 1-serine in astrocytes isolated from stroke-prone spontaneously hypertensive rats. (2006)
  • Author(s): Yamagata, K., Shoji, Y., Terashima, T., Yokogoshi, H.
  • Journal Title: Neuroscience 143(3) Pages: 729-737
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Lipophilicity of capsaicinoids and capsinoids influences the multiple activation process of rat TRPV1. (2006)
  • Author(s): Morita, A., Iwasaki, Y, Kobata, K., Iida, T., Higashi, T., Oda, K., Suzuki, A., Narukawa, M., Sasakuma, S., Yokogoshi, H., Yazawa, S., Tominaga, M., Watanabe, T.
  • Journal Title: Life Sciences 79(24) Pages: 2303-2310
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Relaxation and immunity enhancement effects of ホウ -Aminobutyric acid (GABA) administration in humans. (2006)
  • Author(s): Abdou, A.M., Higashiguchi, S., Horie, K., Kim, M., Hatta, H., Yokogoshi, H.
  • Journal Title: Bio Factors 26(3) Pages: 201-208
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of ovary lipids of skipjack tuna (Katsuwonus pelamis) on gastric injury in rats subject to water immersion restraint stress. (2006)
  • Author(s): Ookawa, K., Mochizuki, K., Sugimoto, Y., Suzuki, T., Hashidume, M., Kitagawa, T., Matumoto, T., Yokogoshi, H.
  • Journal Title: Nippon Shokuhin Kagaku Kogaku Kaishi 53(5) Pages: 305-307
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Flavor components of monoterpenes in citrus essential oils enhance the release of monoamines from rat brain slices. (2006)
  • Author(s): Fukumoto, S., Sawasaki, E., Okuyama, S., Miyake, Y., Yokogoshi, H.
  • Journal Title: Nutritional Neuroscience 9(1-2) Pages: 73-80
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells. (2006)
  • Author(s): Lam, N.V., Chen, W, Suruga, K., Nishimura, N., Goda, T., Yokogoshi, H.
  • Journal Title: Amino Acids 30(1) Pages: 43-48
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Comparative regulation of major enzymes in the bile acid biosynthesis pathway by cholesterol, cholate and taurine in mice and rats. (2005)
  • Author(s): Chen, W, Suruga, K., Nishimura, N., Gouda, T., Lam, V.N., Yokogoshi, H.
  • Journal Title: Life Sci. 77 Pages: 746-757
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of adding dietary L-lysine, L-threonine and L-methionineto a low gluten diet on urea synthesis in rat. (2005)
  • Author(s): Tujioka, K., Lyou, S., Fukaya, S., Sano, A., Hayase, K., H.Yokogoshi
  • Journal Title: Amino Acids 28 Pages: 297-303
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Enhancing effect of taurine on CYP7A1 mRNA expression in Hep G2 cells. (2005)
  • Author(s): Lam, V.N., Chen, W, Nishimura, N., Goda, T., Yokogoshi, H.
  • Journal Title: Amino Acids, Published online 1.1007 Pages: s00726-005-0244-3
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effects of theanine, y-glutamylethylamide, on neurotransmitter release and its relationship with glutamic acid neurotransmission (2005)
  • Author(s): Yamada, T., Terashima, T., Okubo, T., Juneja, L.R., Yokogoshi, H.
  • Journal Title: Nutr.Neurosci. 8(4) Pages: 219-226
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of N-acetylglutamate turnover in urea synthesis of rats given proteins of different quality. (2005)
  • Author(s): Tujioka, K., Fukaya, Y., Sano, A., Hayase, K., okogoshi, H.
  • Journal Title: J.Nutr.Sci.Vitaminol. 51 Pages: 93-98
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Erinacine A increases catecholamine and nerve growth factor content in the central nervous system of rats. (2005)
  • Author(s): Shimbo, M., Kawagishi, H., Yokogoshi, H.
  • Journal Title: Nutr.Res. 25 Pages: 617-623
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of tissue protein synthesis in urea synthesis of rats given proteins of different quality. (2005)
  • Author(s): Tujioka, K., Lyou, S.Hayase, K., Yokogoshi, H.
  • Journal Title: Amino Acids 29 Pages: 21
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of N-Acetylglutamate Degradation and Ornithine Transport into Mitochondria in Urea Synthesis of Rats Given Proteins of Different Quality. (2005)
  • Author(s): Tujioka, K., Hayase, K., Yokogoshi, H.
  • Journal Title: Reports of The Research Committee of Essential Amino Acids (Japan) 172 Pages: 41-44
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Effect of Genistein Treatment on the Brain Protein Synthesis Rate in Ovariectomized Female Rats. (2005)
  • Author(s): Lyou, S., Kawano, S., Okuyama, S., Yamada, T., Tujioka, K., Hayase, K., Yokogoshi, H.
  • Journal Title: Reports of The Research Committee of Essential Amino Acids (Japan) 173 Pages: 65-68
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Role of Tissue Protein Synthesis in Urea Synthesis of Rats Given a Low Gluten Diet Supplemented with Limiting Amino Acids. (2005)
  • Author(s): Tujioka, K., Hayase, K., Yokogoshi, H
  • Journal Title: Reports of The Research Committee of Essential Amino Acids (Japan) 173 Pages: 80-84
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Pungent qualities of sanshool-relatted compounds evaluated by a sensory test and the activation of rat TRPV1. (2005)
  • Author(s): Sugai, K., Morimitsu, Y., Iwasaki, Y., Morita, A., Watanabe, T., Kubota, K.
  • Journal Title: Biosci.Biotech.Biochem. 69 Pages: 1951-1957
  • Description: 「研究成果報告書概要(欧文)」より
• [Book] 抗ストレス食品の開発と展望 (2006)
  • Author(s): 横越 英彦 監修
  • Total Pages: 338
  • Publisher: シーエムシー出版
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 免疫と栄養-食と薬の融合 (2006)
  • Author(s): 横越 英彦
  • Total Pages: 338
  • Publisher: 幸書房
  • Description: 「研究成果報告書概要(和文)」より