2008 Fiscal Year Final Research Report
Autophagy and strategy for intracellular multiplication of pathogenic bacteria
| Project/Area Number |
17390125
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bacteriology (including Mycology)
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| Research Institution | Chiba University |
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Principal Investigator |
YAMAMOTO Tomoko Chiba University, 大学院・薬学研究院, 教授 (60110342)
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| Co-Investigator(Kenkyū-buntansha) |
TAKAYA Akiko 千葉大学, 大学院・薬学研究院, 講師 (80334217)
OYA Mai 千葉大学, 大学院・薬学研究院, 助教 (60456093)
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| Project Period (FY) |
2005 – 2008
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| Keywords | サルモネラ / オートファジー / アポトーシス / 宿主応答 / マクロファージ |
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| Research Abstract |
サルモネラは感染の初期にはマクロファージに細胞死を誘導して殺菌機構をエスケープし、中盤以降はファゴソームをSCVと呼ばれる細胞内オルガネラに成熟させ、増殖する。本研究において、サルモネラのSCV内増殖にはオートファジーに抵抗することが必須であることを明らにした。さらにSPI-1高発現サルモネラはマクロファージに大量のCaspase-3活性化を導き、アポトーシスを誘導することを見出した。マクロファージ内でのSPI-1発現制御は、サルモネラのLon proteaseが、SPI-1転写制御因子HilC, HilDを特異的に認識し分解することに基づくことを明らかにした。
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Research Products
(41 results)
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[Journal Article] Detection of invA, spiC, sipC, invF, and hilA in Salmonella isolated from beef and poulty by dot blot hynridaization in Zambia2008
Author(s)
Hang'ombe, B., Isogai, E., Mubita, C., Isogai, N., Silungwe, M., hisenga, C., Moonga, L., Mulenga, E., Yabe, J., Takaya, A., Yamamoto, T., Kurebayashi, Y. and Isogai, H.
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Journal Title
Inter. J. App. Res. Vet. Med 6
Pages: 1-6
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[Journal Article] Expressed Salmonella antigens within macrophages enhance the proliferation of CD4^+ and CD8^+ T lymphocytes via bystander dendritic cells2007
Author(s)
Eguchi, M., Sekiya, Y., Kikuchi, Y., Takaya, A., Yamamoto, T., Matsui, H.
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Journal Title
FEMS Immunol Med Microbiol 50
Pages: 411-420
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[Journal Article] Prevalence and Genetic Properties of Salmonella enterica Serovar Typhimurium Definitive Phage Type 104 Isolated from Rattus norvegicus and Rattus rattus House Rats in Yokohama City, Japan. Appl. Environ2007
Author(s)
Yokoyama, E., Maruyama, S., Kabeya, H., Hara, S., Sata, S., Kuroki, T., and Yamamoto, T
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Journal Title
Microbiol 73
Pages: 2624-2630
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[Journal Article] De-repression of Salmonella Pathogenicity Island 1 genes within macrophages leads to rapid apoptosis via caspase-1- and caspase-3- dependent pathways2005
Author(s)
Takaya A, Suzuki, A., Kikuchi, Y., Eguchi, M., Isogai, E., Tomoyasu, T., Yamamoto, T.
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Journal Title
Cell Microbiol 7
Pages: 79-90
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[Journal Article] Evaluation of the Lon-deficient Salmonella strains as an oral vaccine candidate2005
Author(s)
Kodama, C., Eguchi, M., Sekiya, Y., Yamamoto, T., Kikuchi, Y., Matsui, H
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Journal Title
Microbiol. Immunol 49
Pages: 1035-1045
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[Presentation] Type VI secretion system via outer membrane vesicle releases Salmonella PagC protein2006
Author(s)
Takaya, A., Mizunoe, Y., Takade, A., Sashinami, H., Isogai, E., Nakane, A., Yoshida, S. and Yamamoto, T
Organizer
leading to attenuation of Salmonella virulence. ASM conference ; Protein Traffic in Prokaryotes
Place of Presentation
Iraklio Crete, Greece
Year and Date
20060000
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