2007 Fiscal Year Final Research Report Summary
Prevention for allergic diseases by clarification of interaction between environmental chemicals and genes of eosinophil-related protein
| Project/Area Number |
17390174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Kanazawa University (2006-2007)
Kochi University (2005) |
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Principal Investigator |
NAKAMURA Hiroyuki Kanazawa University, Graduate School of Medical Science, Professor (30231476)
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| Co-Investigator(Kenkyū-buntansha) |
AKIMARU Kunihiro Kochi University, School ofMedicine, Assistant Professor (50281184)
OGINO Keiki Okayama University, Graduate School of Medicine, DentistryandPharmaceutical Sciences, Professor (70204104)
HITOMI Yoshiaki Kanazawa University, Graduate School ofMedical Science, Associate Professor (70231545)
KAMBAYASHI Yasuhiro Kanazawa University, Graduate School ofMedical Science, Associate Professor (20345630)
HIBINO Yuri Kanazawa University, Graduate School ofMedical Science, Assistant Professor (40362008)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Allergy / Single nucleotide nolvmorohisms (SNP) of genes / Asthama / Japanese cedar nollinosis / Diesel exhaust particulate (DEP) / Eosinoohils / Asthma model mice / Prevention |
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| Research Abstract |
To propose tailor-made preventive methods for allergic diseases by clarification between environment and genes, we compared single nucleotide polymorphisms (SNP) of genes of eosinophil-related protein, e.g., CC chemokine receptor (CCR) family, Eotaxin/CCL11, Eotaxin-2/CCL24, Eotaxin-3/CCL26, Monocyte chemoattractant protein -1 (MCP-1, CCL2) between patients with asthma or Japanese cedar pollinosis and controls. We recognized significantly higher frequencies of 51 C in CCR3 gene, 2497G and 2563C in CCL26 gene, and 2518G in MCP-1 gene in patients with asthma or Japanese cedar pollinosis as compared to controls. There were significant correlations between serum levels of those proteins and severity of those allergic diseases. These results suggest the clinical significance of those eosinophils-related proteins in allergic diseases. Next, we developed the novel preventive methods for allergy, using the filter system incorporating activated carbon and amorphous iron(hydr)oxide, which efficiently removes diesel exhaust particulate (DEP). We demonstrated that removal of DEP by the filter system produced significant inhibition of allergic responses, e. g, eosinophils and neutrophils infiltration into lung tissues, lung inflammation and elevated Der f specific IgGl antibody level in asthma model mice BALB/c, which were sensitized and stimulated with Der f. Therefore, this filter system might be the most effective to prevent allergy development, if its use were started in our life as early as possible (e.g. in our infancy).
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Research Products
(34 results)
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[Journal Article] Association between physical restraint and drug-induced liver injury2008
Author(s)
Hatta, K., Shibata, N., Ota, T., Usui, C., Ito, M., Nakamura, H., Arai, H
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Journal Title
Neuropsycho biology 56(4)
Pages: 180-184
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Relationship between mental health of Japanese residents and the quality of medical service.2007
Author(s)
Yoshino S, Sasahara S, Maeno T, Kitaoka-Higashiguchi K, Tomotsune Y, Taniguchi K, Tomita E, Usami K, Haoka T, Nakamura H, Matsuzaki I.
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Journal Title
J Phys Fit Nutri Immunol. 7(1)
Pages: 3-11
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis.2007
Author(s)
Nakamura H, Higashikawa F, Nobukuni Y, Miyagawa K, Endo T, Imai T, Hatta K, Ozasa K, Motohashi Y, Matsuzaki I, Sasahara S, Ogino K, Akimaru K, Eboshida A.
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Journal Title
Int Arch Allergy Immunol. 142(2)
Pages: 329-334
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Psychological factors including sense of coherence and some lifestyles are related to General Health Questionnaire-12 (GHQ-l2) in elderly workers in Japan2007
Author(s)
Matsuzaki, I., Sagara, T., Ohshita, Y., Nagase, H., Ogino, K., Eboshida, A., Sasahara, S., Nakamura, H
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Journal Title
Environ Health Prev Med 12(2)
Pages: 71-77
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] I Relationship between mental health oflapanese residents and the quality of medical service2007
Author(s)
Yoshino, S., Sasahara, S., Maeno, T., Kitaoka-Higashiguchi, K., Tomotsune, Y., Taniguchi, K., Tomita, E., Usami, K., Haoka, T., Nakamura, H., Matsuzaki
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Journal Title
J Phys Fit Nutri Immunot 7(1)
Pages: 3-11
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Maximal response to electroconvulsive therapy for the treatment of catatonic symptoms2007
Author(s)
Hatta, K., Miyakawa, K., Ota, T., Usui, C., Nakamura, H., Arai, H
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Journal Title
J ECT 23(4)
Pages: 233-235
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Genotypes and haplotypes of CCR2 and CCR3 genes in Japanese cedar pollinosis2007
Author(s)
Nakamura, H., Higashikawa, F., Nobukuni, Y., Miyagawa, K., Endo, T., Imai, T., Hatta, K., Ozasa, K., Motohashi, Y., Matsuzaki, I., Sasahara, S., Ogino, K., Akimaru, K., Eboshida, A
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Journal Title
Int Arch Allergy Immune 142(2)
Pages: 329-334
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Relationship between sense of coherence in the final stage of pregnancy and post-partum stress reactions2006
Author(s)
Sekizuka, N., Nakamura, H., Shimada, K., Tabuchi, N., Kameda, Y., Sasano, K., Sakai, A
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Journal Title
Environ Health Prevent Med 11(4)
Pages: 199-205
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Eradication of epstein-barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNA1.2005
Author(s)
Nasimuzzaman M, Kuroda M, Dohno S, Yamamoto T, Iwatsuki K, Matsuzaki S, Mohammad R, Kumita W, Mizuguchi H, Hayakawa T, Nakamura H, Taguchi T, Wakiguchi H, Imai S.
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Journal Title
Mol Ther. 11(4)
Pages: 578-590
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Influences of the stress coping ability of supervisors on the stress situation of their subordinates2005
Author(s)
Tatsukawa, H., Sasahara, S., Yoshino, S., Tomotsune, Y., Taniguchi, K., Nakamura, H., Matsuzaki, I
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Journal Title
J Phys Fit Nutri Inununol 15(2)
Pages: 82-87
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Eradication of epstein-barr virus episome and associated inhibition of infected tumor cell growth by adenovirus vector-mediated transduction of dominant-negative EBNAI2005
Author(s)
Nasimuzzaman, M., Kuroda, M., Dohno, S., Yamamoto, T., Iwatsuki, K., Matsuzaki, S., Mohammad, R., Kumita, W., Mizuguchi, H., Hayakawa, T., Nakamura, H., Taguchi, T., Wakiguchi, H., Imai, S
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Journal Title
Mol Thar 11(4)
Pages: 578-590
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Prevention for the development of allergic diseases produced by environmental chemicals2008
Author(s)
Nakamura, H., Hirota, R., Akimaru, K., Suganuma, N., Kang, Yumei., Sakurai, K
Organizer
The 6th Special Research Project of Green Sciences, Open Symposium
Place of Presentation
Kochi, Japan
Year and Date
20080300
Description
「研究成果報告書概要(欧文)」より
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