2007 Fiscal Year Final Research Report Summary
Cellular mechanisms of contractile and vasodilating actions of anesthetics in vascular smooth muscle
| Project/Area Number |
17390430
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Anesthesiology/Resuscitation studies
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| Research Institution | Kagoshima University |
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Principal Investigator |
KANMURA Yuichi Kagoshima University, Graduate School of Medical and Dental Sciences, Professor (30211189)
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| Co-Investigator(Kenkyū-buntansha) |
TUNEYOSHI Isao Miyazaki University, Faculty of Medicine, Professor (90301390)
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| Project Period (FY) |
2005 – 2007
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| Keywords | smooth muscle vascular / signal transduction / pharmacolo / anesthesiology |
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| Research Abstract |
First year; Objective: To determine the direct contractile effects of angiotensin II (AII)and vasopressin (VP), and the effects of combinations of these agonists, in human isolated gastroepiploic arteries in vitro. Conclusion: There is a powerful synergism between the contractile effects of low-dose VP and AII in this human isolated artery. Moreover, the elevations of plasma AII and VP levels during hemorrhage suggest that this synergism may be both physiologically and clinically important in optimizing vasoconstriction and maintaining blood pressure in such critical states.
Second year; Objective: There are few data available on the effect of ultrasonic skeletonization with the harmonic scalpel on internal thoracic artery (ITA)and gastroepiploic artery (GEA) vessel function. Conclusion: Ultrasonic complete skeletonization with the harmonic scalpel may retain smooth muscle function of skeletonized grafts, whereas endothelial function of ultrasonic skeletonized grafts may be significantly compromised.
Third year; Objective; In the direct contractile effects of angiotensin II (AII), this peptide induced strong tachyphylaxis, and thus the contractile performance were degraded in a short time. Therefore, the aim of this study is to determine the mechanisms responsible for the AII-induced tachyphylaxis in human vascular smooth muscle, such as a gastroepiploic arteries. Conclusion; There is a possibility that vasodilator prostaglandins, which are released by AII, are involved in AII tachyphylaxis in humans, since pretreatment with indomethacin reduces, but dose not abolish, the tachyphylaxis
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Research Products
(36 results)
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[Journal Article] Clinical effects of a neutrophil elastase inhibitor, sivelestat, in patients with acute respiratory distress syndrome2006
Author(s)
Okayama, N, Kakihana, Y, Setoguchi, D, Imabayashi, T, Omae, T, Matsunaga, A, Kanmura, Y
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Journal Title
Journal of Anesthesia, peer reviewed 20
Pages: 6-10
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Carvedilol versus Metoprolol for the pervention of atrial fibrillation after off-pump coronary bypass surgery : rationale and design of the Carvedilol or Metoprolol Post-Revacularization Atrial Fibrillation Controlled Trial(COMPACT)2006
Author(s)
Kamei, M, Morita, S, Hayashi, Y, Kanmura, Y, Kuro, M
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Journal Title
Cardiovascular Drugs and Therapy, peer reviewed 20
Pages: 219-227
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effects of ultrasonic skeletonization on internal thoracic and gastroepiploic arteries for coronary artery bypass grafting2006
Author(s)
Matsumoto, K, Tsuneyoshi, I, Iguro, Y, Kinjo, T, Yotsumoto, G, Ueno, M, Kanmura, Y
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Journal Title
European Journal of Cardio-thoracic Surgery, peer reviewed 30
Pages: 592-596
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Hemodynamic changes during off-pump coronary artery bypass anastomosis inpatients with coexisiting mitral regurgitation : improvement with milrinone2005
Author(s)
Omae, T, Kakihana, Y, Matsunaga, A, Tsuneoshi, I, Kawasaki, K, Kanmura, Y, Sakata, R
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Journal Title
Anesthesia & Analgesia, peer reviewed 101
Pages: 2-8
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Differential pharmacologic sensitivities of phosphodiesterase-3 inhibitors among human isolated gastroepiploic, internal mammary, and radial arteries2005
Author(s)
Onomoto, M, Tsuneyoshi, I, Yonetani, A, Suehiro, S, Matsumoto, K, Sakata, R, Kanmura, Y
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Journal Title
Anesthesia & Analgesia, peer reviewed 101
Pages: 950-956
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Causing Mediators in septic shock : comparative study of anandamide and tetrahydrobiopterin2006
Author(s)
Kakihana, Y, Setoguchi, D, Sonoda, T, Takahashi, Y, Hayashida, K, Imabayashi, T, Matsunaga, A, Kanmura, Y
Organizer
The 27th Annual Meeting of Japan Society of Circulation Control in Medicine
Place of Presentation
Tokyo
Year and Date
2006-05-19
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Interaction s of vasoconstrictive hormones in human gastro-epiploic arteries2005
Author(s)
Tsuneyoshi, I, Hidaka, T, Nakano, Y, Yonetani, A, Yamashita, A, Kanmura, Y
Organizer
The 43th Kyushu regional Conference of Japanese Society of Anesthesiologists
Place of Presentation
Saga
Year and Date
20051709
Description
「研究成果報告書概要(欧文)」より
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[Presentation] Protective effect of perfluorocar bon (PF-77) on air bubble-induced endothelial damage2005
Author(s)
Tsuneyoshi, I, Onomoto, M, Yonetani, A, Maruko, K, Minoda, Y, Kanmura, Y
Organizer
The 52th Annual Meeting of Japanese Society of Anesthesiologists
Place of Presentation
Hyogo
Year and Date
2005-06-02
Description
「研究成果報告書概要(欧文)」より
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