2007 Fiscal Year Final Research Report Summary

Gene therapy targeting lipid mediators for prevention of bone destruction

Research Project

Project/Area Number	17390529
Research Category	Grant-in-Aid for Scientific Research (B)
Allocation Type	Single-year Grants
Section	一般
Research Field	Surgical dentistry
Research Institution	The University of Tokyo
Principal Investigator	HIKIJI Hisako The University of Tokyo, Faculty of medicine, Assistant professor (50292876)
Co-Investigator(Kenkyū-buntansha)	TAKATO Tuyoshi The University of Tokyo, Faculty of medicine, Professor (90171454) MIZUKAMI Hiroaki Jichi Medical School, Faculty of medicine, Assistant professor (20311938) ISHII Satoshi The University of Tokyo, Faculty of medicine, Associate professor (10300815) KOYAMA Hiroyuki The University of Tokyo, Faculty of medicine, Specially appointed associate professor (10241994) KATAYAMA Kazunori The University of Tokyo, Faculty of engineering, Professor (00130245)
Project Period (FY)	2005 – 2007
Keywords	lipid mediator / bone destruction / osteoclast / platelet-activating factor
Research Abstract	Bone-resorptive diseases such as osteoporosis, rheumatoid arthritis, osteoarthritis, and periodontitis enhanced the production of a variety of lipid mediators. Platelet-activating factor (PAF) is one of the potent lipid mediators. -This study has shown that PAF receptor deficient mice develop only mild osteoporosis. Osteoclastic bone resorption is impaired in these deficient mice. This investigation also focuses on the other families of lipids and their function during bone metabolism and disease.

(4 results)