2007 Fiscal Year Final Research Report Summary
Effect of polyphenol-containing azuki bean extract on blood pressure and stroke in an experimental model of hypertension
| Project/Area Number |
17500545
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Eating habits, studies on eating habits
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| Research Institution | Aomori University of Health and Welfare |
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Principal Investigator |
SATO Shin Aomori University of Health and Welfare, Faculty of Health Sciences, 准教授 (40310099)
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| Co-Investigator(Kenkyū-buntansha) |
KURASAKI Masaaki Hokkaido University, Research Faculty of Environmental Earth Science, 助教 (80161727)
MUKAI Yuuka Hakodate Junior College, Department of Food and Nutrition, 准教授 (60331211)
HATAI Asako Hakodate Junior College, Department of Food and Nutrition, 教授 (60002557)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Food / Azuki polyphenol / Hypertension / Stroke / Nitric oxide / Nitric oxide synthase / Macrophage |
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| Research Abstract |
Hypertension is known to be a major risk factor for myocardial infarction, stroke, and renal damage, and has also been shown to have proinflammatory actions, which increase the formation of reactive oxygen species such as superoxide (O_2-). In addition, infiltration by immunocompetent cells such as macrophages is thought to play a role in the pathogenesis of hypertension. Although the azuki bean (Vigna angularis) is known to be one of the most important crops, little is known about the beneficial effects of a diet of azuki beans on the progression of hypertension.
In the present study, we investigated the effect of treatments of azuki beans extract (ABE) containing polyphenols with radical scavenging activities on high blood pressure in a rat model with hypertension, and whether the ABE affects O_2 production and macrophages infiltration in the aorta and kidney in chronic hypertension. Experiment 1 : Stroke-prone spontaneously hypertensive rats (SHRSP) were fed 0% and 0.9% ABE-containin
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g diets. Tail systolic blood pressure (SBP) and O_2 production in the aorta and kidney were examined. The elevation of SBP in the ABE-treated SHRSP was not suppressed compared with the untreated SHRSP. On the other hand, The NADPH-stimulated O_2 levels in the ABE-treated SHR was decreased significantly, compared with the untreated SHR. Experiment Z Spontaneously hypertensive rats (SHR) and control normotensive Wistar Kyoto rats (WKY) were fed 0% and 0.8% ABE-containing diets, respectively. Tail SBP and macrophage kinetics in the heart and kidney were examined. After 8 weeks of ABE treatment, the elevation of SBP in the ABE-treated SHR was significantly suppressed compared with the untreated SHR. In the immunohistochemical analyses, the number of macrophages in the heart and kidney in the ABE-treated SHR showed a significant decrease in number compared with the untreated SHR.
In conclusion, these results suggested that ABE attenuated the elevation of SBP, O_2 production and macrophage infiltration of this SHR model. Less
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Research Products
(46 results)
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[Journal Article] Effect of polyphenol-containing azuki bean (Vigna angularis) extract on blood pressure elevation and macrophage infiltration in the heart and kidney of spontaneously hypertensive rats.2008
Author(s)
Sato, S., Mukai, Y., Yamate, J., Kato, J., Kurasaki, M., Hatai A., Sagai, M
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Journal Title
Clin Exp Pharmacol Physiol 35
Pages: 43-49
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] An analysis which uses nutrient intake as a risk factor of stroke incidence-a study based on multiple regression analysis of estimated risks(Japanese)2008
Author(s)
Komada, A., Yamada, M., Morinaga, Y., Izawa, H., Sato, S., Sagai, M
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Journal Title
Journal of Japan Academy of Human Care Science 1
Pages: 32-42
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] On a relation between a change by aging and the Japanese Health Practice Index (JHPI)(Japanese)2008
Author(s)
Yamada, M., Komada, A., Morinaga, Y., Izawa, H., Sato, S., Sagai, M
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Journal Title
Journal of Japan Academy of Human Care Science. 1
Pages: 70-76
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Polyphenol- containing azuki bean extract suppresses blood pressure, and renal and vascular nitric oxide synthase expression in spontaneously hypertensive rats (SHR)2006
Author(s)
Sato, S., Nozawa, M., Hatori, Y., Kato, J., Sagai, M
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Journal Title
International Proceedings from XIII Congress of the Society for Free Radical Research International, Medimond, Bologna, Italy
Pages: 313-317
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effect of polyphenol-containing azuki bean extract on blood pressure, and renal and vascular nitric oxide synthase expression in spontaneously hypertensive rats.2006
Author(s)
Sato, S., Hatori, Y., Nozawa, M., Kato, J., Sagai, M
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Journal Title
Clin Exp Hypertensions 28
Pages: 601
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effect of yam (Dioscorea batata)- containing diet on memory deterioration and brain NOS expression in senescence-accelerated mice (SAM)2006
Author(s)
Sagai, M., Hatori, Y., Komada, A., Sato, S
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Journal Title
International Proceedings from XIII Congress of the Society for Free Radical Research International, Medimond, Bologna, (Italy)
Pages: 305-308
Description
「研究成果報告書概要(欧文)」より
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