2007 Fiscal Year Final Research Report Summary
Effects of nitrophenols isolated from diesel exhaust particles on reproductive and endocrine system
| Project/Area Number |
17510052
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Risk sciences of radiation/Chemicals
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| Research Institution | National Institute for Environmental Studies |
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Principal Investigator |
SUZUKI Akira National Institute for Environmental Studies, RESEARCH CENTER OF ENVIRONMENTAL RISK, SENIOR RESEARCHER (20124349)
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| Co-Investigator(Kenkyū-buntansha) |
TANEDA Shinji NIES, 環境リスク研究センター, POST DOCTORIAL FELLOWS (90391127)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Nitroohenol / PNP / diesel exhaust Particles / DEP / PNMC / PNMPP / reproductive effects / toxicology |
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| Research Abstract |
We examined the effects of nitrophenols, firstly isolated from diesel exhaust particles by us, on reproductive endocrine system using rats and Japanese quails. We dearly showed that these nitrophenols had estrogenic and anti-androgenic activities in rats by in vivo or in vitro experiments. The activities of these compounds, however, were different by differences of the architecture of the compounds. Two species of the compounds were clarified to a primary reductive substance of insecticide showing very important suggestions on ecological effects. The results were summarized as follows; 1). 4-ntorophenol (PNP) dearly showed high estrogenic and anti-androgenic activities. PNP is a primary reductive substance of insecticide parathion that is widely used in the developing country in the world. PNP caused severe atrophy of testes of Japanese quails suggesting a high anti-androgenic activity 2). 3-methyl-4-nitrophenol showed lower activities than that of PNP. PNMC is a primary reductive substance of insecticide fenitrothion that is used in the world include in Japan. 3). 4-nitro-3-phenyl phenol (PNMPP) showed the highest activities in these compounds. 4). 2-nitrophenol did not show any activities in rats. These results dearly showed structure-activity relationships, too.
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Research Products
(60 results)
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[Journal Article] Improvement of an Efficient Separation Method for Chemicals in Diesel Exhaust Particles:Analysis for Nitrophenols,Sample preparations,separation techniques and analytical methods to determine organic and inorganic compounds.2008
Author(s)
Noya Yoichi,Mikami Yusuke,Taneda Shinji,Mori Yoki,Suzuki Akira K.,Ohkura Kazue,Yamaki Kouya,Yoshino Shin and Seki Koh-ichi
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Journal Title
Environ.Sci.Pollut.Res., DOI 10.1007/s11356-008-0006-3 15
Pages: 318-321
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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[Journal Article] Improvement of an Efficient Separation Method for Chemicals in Diesel Exhaust Particles : Analysis for Nitrophenols, Sample preparations, separation techniques and analytical methods to determine organic and inorganic compounds2008
Author(s)
Noya Yoichi, Mikami Yusuke, Taneda Shinji, Mori Yoke, Suzuki Akira K., Ohkura Kazue, Yamaki Kouya, Yoshino Shin, Seki Kohichi
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Journal Title
Environ. Sci. pollut. Res. 15
Pages: 318-321
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Effect of methimazol-induced hypothyroidism on adrenal and gonadal functions in male Japanese quail(Coturnix japonica),Published online Oct.23,20072007
Author(s)
Weng Q.,Saita E.,Watanabe G.,Takahashi S.,Sedqyar M.,Suzuki AK.,Taneda S.,Taya K.
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Journal Title
J.Reprod.Dev., 53
Pages: 1335-1341
Description
「研究成果報告書概要(和文)」より
Peer Reviewed
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