Development of fullerene derivatives for new anti-cancer and and-virus drugs lead compounds

2007 Fiscal Year Final Research Report Summary

• Project/Area Number: 17590092
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Drug development chemistry
• Research Institution: Kyoritsu University of Pharmacy
• Principal Investigator: MASHINO Tadahiko Kyoritsu University of Pharmacy, Department of Pharmaceutical Sciences, Professor (90165697)
• Co-Investigator(Kenkyū-buntansha): NAKAMURA Shigeo Kyoritsu University of Pharmacy, Department of Pharmaceutical Sciences, Associate Professor (00264078) ; TAKAHASHI Kyoko Kyoritsu University of Pharmacy, Department of Pharmaceutical Sciences, Assistant Professor (90255381) ; NISHIZAWA Thiho Kyoritsu University of Pharmacy, Department of Pharmaceutical Sciences, Post doctoral fellow (50448990)
• Project Period (FY): 2005 – 2007
• Keywords: Fullerene / anti-cancer drug / and HIV drug / anti-hepatitis C virus drug / HIV reverse transcriptase / hepatitis C virus RNA polymerase / apoptosis

Research Abstract

1. Cancer cell proliferation inhibition mechanism of fullerene derivatives.
It had already been reported that the pyrrolidinium type fullerene derivative (1) showed the cancer cell proliferation inhibition effect. We investigated the mechanism of inhibition using HL-60 cell line. Treatment of 1 induced the features of apoptosis and also induced the Caspase 3 and 9 activation and cytochromec release from mitochondria. But p53 induction was not observed. It is thought that the compound causes apoptosis without p53 induction is advantageous as the anti-cancer drug, because p53 is loss in cancer cells in many cases.
2. Design and synthesis of praline type fullerene derivatives with high HIV reverse transcriptase inhibition activity.
Using the computer docking simulation, various fullerene derivatives were designed and synthesized based on the structure of derivative (2) that had three carboxylic acids in the pyrrole ring. Relationship between the inhibition activity and number and position of carboxylic acid acids in the pyrrole ring was investigated and more active derivative 3 was developed. The inhibition activity of 3 was 100 times or more high than Nevirapin, which is used as and HIV drug.
3. Anti-hepatitis C virus activity of fullerene derivatives
Sulfonium type fullerene derivative (4) showed excellent hepatitis C virus RNA polymerase inhibition activity and hepatitis C virus growth inhibition activities. Cytotoxicity of 4 was low. 4 is a promising lead compound of the anti-hepatitis C virus medicine.
In this three years project, we developed the novel promising lead compounds for anti-cancer, anti-HIV, and anti-HCV medicine.

Research Products

• [Journal Article] C60 Nanowhisker Field-Effect-Transistor Application for Nano-Electronics (2008)
  • Author(s): Ogawa K, Aoki N, Miyazawa K, Nakamura S, Mashino T, Bird J P, Ochiai Y.
  • Journal Title: Jpn J Appl Phys 47(1) Pages: 501-504
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] C_60 Nanowhisker Field-Effect-Transistor Application for Nana-Electronics (2008)
  • Author(s): Ogawa, K., Aoki, N., Miyazawa, K., Nakamura, S., Mashino, T., Bird, J P, Ochiai Y*
  • Journal Title: Jpn J Appl Phys 47(1) Pages: 501-504
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Novel Metabolic Pathways of p-n-NonylphenoI Catalyzed by Cytochrome P450 and Estrogen Receptor Binding Activity of New Metabolites (2007)
  • Author(s): Tezuka, Y., Takahashi, K., Suzuki, T., Kitamura, S., Ohta, S., Nakamura, S., Masluno, T*
  • Journal Title: J Health Sci 53(5) Pages: 552-561
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Synthesis of novel ammo acid-type fullerenes and their inhibition activity of HN reverse transcriptase and HCV RNA polymerase (2006)
  • Author(s): Nakamura S, Ikegami N, Harada M, Shimotohno K, Takahashi K, Mashino T^*.
  • Journal Title: J Kyoritsu Univ Pharm 1 Pages: 77-84
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] Structural characterization of room-temperature synthesized fullerene nanowhiskers (2006)
  • Author(s): Miyazawa K^*, Minato J, Mashino T, Nakamura S, Fujino M, Suga T.
  • Journal Title: NUKLEONIKA 51 Pages: S41-S48
  • Description: 「研究成果報告書概要(和文)」より
  • Peer Reviewed
• [Journal Article] フラーレンの医薬への応用 (2006)
  • Author(s): 増野 匡彦
  • Journal Title: 臨床検査 50(12) Pages: 1429-1438
  • Description: 「研究成果報告書概要(和文)」より
• [Journal Article] Synthesis of novel amino acid-type fullerenes and their inhibition activity of HN reverse transcriptase and HCV RNA polymerase (2006)
  • Author(s): Nakamura, S., Ikegami, N., Harada, M., Shimotohno, K., Takahashi, K., Mashino, T*
  • Journal Title: J Kyoritsu Univ Pharm 1 Pages: 77-84
  • Description: 「研究成果報告書概要(欧文)」より
• [Journal Article] Structural characterization of room-temperature synthesized fullerene nanowhiskers (2006)
  • Author(s): Miyazawa, K*., Minato, J., Mashino, T., Nakamura, S., Fujino, M., Suga, T
  • Journal Title: NUKLEONIKA 51 Pages: S41-S48
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Effect of alkyl chain in pyrrolidinium-type fullerene derivatives on induction of apoptosis (2008)
  • Author(s): Yokoo, S., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20080300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of sulfonium fullerene derivatives with anti HCV activity (2008)
  • Author(s): Mod, Y., Shimotohno, K., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20080300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] HIV reverse transcriptase inhibition activity of 5-aryl praline-type fullerene derivatives (2008)
  • Author(s): Akiho, Y., Takeuchi, Y., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 128th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Yokohama, Japan
  • Year and Date: 20080300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] アルキル基導入ピロリジニウム型フラーレン誘導体のアポトーシス誘導効果 (2008)
  • Author(s): 横尾 祥子, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 抗HCV薬を目指したスルポニウム置換基を有するフラーレン誘導体の合成 (2008)
  • Author(s): 森裕 美子, 下遠野 久美子, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 5位に芳香環を有するプロリン型フラーレン誘導体のHIV逆転写酵素阻害活性 (2008)
  • Author(s): 秋保 裕子, 竹内 由紀, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 日本薬学会第128年会
  • Place of Presentation: 横浜
  • Year and Date: 2008-03-26
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] New proline-type fullerene derivatives that have HIV reverse transcriptase inhibition activity (2007)
  • Author(s): Nakamura, S., Kasahara, Y., Fukasawa, M., Mod, Y., Takahashi, K., Shimotohno K, Mashino, T
  • Organizer: 26th Medicinal Chemistry Symposium
  • Place of Presentation: Sagamihara, Japan
  • Year and Date: 20071100
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of diastereomers of sulfonium fullerene derivatives with anti HCV activity (2007)
  • Author(s): Akiho, Y., Takeuchi, Y., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 51th Annual Meeting of the Pharmaceutical Society of Japan Kanto Branch
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20071000
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis, TEM and Raman spectroscopic analysis of Nano whisker from fullerene derivatives (2007)
  • Author(s): Mashino, T., Nakamura, S., Saito, K., Kizuka, T., Miyazawa, K
  • Organizer: 68th The Japan Society of Applied Physics, autumn meeting
  • Place of Presentation: Sapporo, Japan
  • Year and Date: 20070900
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Development of fullerene derivative as a lead compound of new drugs (2007)
  • Author(s): Mashino, T
  • Organizer: 1st The Chemical. Society of Japan/Kanto Branch Meeting
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20070900
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Apoptosis induction and generation of reactive oxygen species by cationic fullerene derivative (2007)
  • Author(s): Nishizawa, C., Hashimoto, N., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 29th Annual Meeting of the Society of Free Radical, Japan
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 20070600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] TEM and Ranran Spectroscopy Analyses of Fullerene Nanowbiskers and Nanotubes (2007)
  • Author(s): Miyazawa K, Ringor C, Nakamura K, Tachibana M, Mashino T, Nakamura S.
  • Organizer: Nanotech 2007
  • Place of Presentation: Santa Clara,USA
  • Year and Date: 20070500
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Antioxidant Activity of Fullerene Derivative Lacking Prooxidant Activity (2007)
  • Author(s): Nakamura, S., Satake, E., Hatanaka, M., Takahashi, K., Mashino, T
  • Organizer: 211th Meeting of The Electrochemical Society
  • Place of Presentation: Chicago, USA
  • Year and Date: 20070500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Generation of Reactive Oxygen Species by Antiproliferative Fullerene Derivative (2007)
  • Author(s): Nishizawa, C., Hashimoto, N., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 211th Meeting of The Electrochemical Society
  • Place of Presentation: Chicago, USA
  • Year and Date: 20070500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] TEM and Raman Spectroscopy Analyses of Fullerene Nanowhiskers and Nanotubes (2007)
  • Author(s): Miyazawa, K., Ringor C, Nakamura, K., Tachibana, M., Mashino, T., Nakamura, S
  • Organizer: Nanotech 2007
  • Place of Presentation: Santa Clara, USA
  • Year and Date: 20070500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Antiproliferative cationic fullerene derivatives induce oxidative stress in HL-60 cell (2007)
  • Author(s): Nishizawa, C., Hashimoto, N., Mori, Y., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama, Japan
  • Year and Date: 20070300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Design and synthesis of novel praline-type fullerene derivatives that have HIV reverse transcriptase inhibition activity (2007)
  • Author(s): Akiho, Y., Yokoo, S., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama, Japan
  • Year and Date: 20070300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Apoptosis induction by the antiproliferative cationic fullerene derivative (2007)
  • Author(s): Hashimoto, N., Nishizawa, C., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 127th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Toyama, Japan
  • Year and Date: 20070300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Fullerene derivatives have antioxidant activity but no metal-dependent pro oxidant activity (2007)
  • Author(s): Nakamura, S., Satake, E., Hatanaka, M., Takahashi, K., Matsubayashi, K., Mashino, T
  • Organizer: The 32th Fullerene-Nanotubes General Symposium
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 20070200
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] TEM and Raman Spectroscopy Analyses of Fullerene Derivative Nano whiskers and Fullerene Nano tubes (2007)
  • Author(s): Miyazawa, K., Cherry, Ringer, Mashino, T., Nakamura, S
  • Organizer: The 32th Fullerene-Nanotubes General Symposium
  • Place of Presentation: Nagoya, Japan
  • Year and Date: 20070200
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] 抗HCV活性を有する新規フラーレン誘導体 (2007)
  • Author(s): 中村 成夫, 笠原 優子, 深澤 征義, 森裕 美子, 高橋 恭子, 下遠野 久美子, 増野 匡彦
  • Organizer: 第26回メディシナルケミストリーシンポジウム
  • Place of Presentation: 相模原
  • Year and Date: 2007-11-23
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] プロリン型フラーレン誘導体の立体異性体の合成とHIV逆転写酵素阻害活性 (2007)
  • Author(s): 秋保 裕子, 竹内 由紀, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 第51回日本薬学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2007-10-06
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] 医薬品リード化合物を目指したフラーレン誘導体の開発 (2007)
  • Author(s): 増野 匡彦
  • Organizer: 第1回日本化学会関東支部大会
  • Place of Presentation: 東京
  • Year and Date: 2007-09-27
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] フラーレン誘導体ナノウィスカーの合成とTEM、ラマン分光分析 (2007)
  • Author(s): 増野 匡彦, 中村 成夫, 斎藤 一真, 木塚 徳志, 宮澤 薫一
  • Organizer: 第68回応用物理学会
  • Place of Presentation: 札幌
  • Year and Date: 2007-09-04
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] がん細胞におけるカチオン型フラーレン誘導体によるアポトーシスの誘導と活性酸素の生成 (2007)
  • Author(s): 西澤 千穂, 橋本 規行, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 第29回日本フリーラジカル学会学術集会 日本過酸化脂質、フリーラジカル学会第31回大会
  • Place of Presentation: 名古屋
  • Year and Date: 2007-06-09
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Antioxidant Activity of Fullerene Derivative Lacking Prooxidant Activity (2007)
  • Author(s): Nakanura S, Satake E, Hatanaka M, Takahashi K, Mashino T.
  • Organizer: 211th Meeting of The Electrochemical Society
  • Place of Presentation: Chicago,USA
  • Year and Date: 2007-05-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Generation of Reactive Oxygen Species by Antiproliferative Fullerene Derivative (2007)
  • Author(s): Nishizawa C, Hashimoto N, Takahashi K, Nakamura S, Mashino T.
  • Organizer: 211th Meeting of The Electrochemical Society
  • Place of Presentation: Chicago,USA
  • Year and Date: 2007-05-07
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] HIV逆転写酵素阻害活性を有する新規フラーレン誘導体のデザインと合成 (2007)
  • Author(s): 秋保 裕子, 横尾 祥子, 高橋 恭子, 中村 成夫, 増野 匡彦.
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] がん細胞増殖抑制効果を持つカチオン型フラーレン誘導体のアポトーシス誘導 (2007)
  • Author(s): 橋本 規行, 西澤 千穂, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] がん細胞増殖抑制効果を有するカチオン型フラーレン誘導体による細胞内酸化ストレスの惹起 (2007)
  • Author(s): 西澤 千穂, 橋本 規行, 森裕 美子, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 日本薬学会第127年会
  • Place of Presentation: 富山
  • Year and Date: 2007-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Fullerene derivatives have antioxidant activitsbut no metal-dependentprooxidant activity (2007)
  • Author(s): 中村 成夫, 佐竹 恵理子, 畑中 雅史, 高橋 恭子, 松林 賢司, 増野 匡彦
  • Organizer: 第32回フラーレン・ナノチューブ総合シンポジウム
  • Place of Presentation: 名古屋
  • Year and Date: 2007-02-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] TEM and Raman Spectroscopy Analyses of Fullerene Derivative Nanowhiskers and Fullerene Nanotubes (2007)
  • Author(s): 宮澤 薫一, チェリー・リンゴル, 増野 匡彦, 中村 成夫
  • Organizer: 第32回フラーレン・ナノテューブ総合シンポジワム
  • Place of Presentation: 名古屋
  • Year and Date: 2007-02-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Induction of reactive oxigen wpecies bt antiproliferative cationic fullerene derivatives in HL-60 cell (2006)
  • Author(s): Nishizawa, C., Hashimoto, N., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 21th Annual Meeting of the Society of Free Radical, Japan Kanto Branch
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20061200
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Synthesis of nano whisker by fullerene derivative, and its physical properties (2006)
  • Author(s): Mashino, T
  • Organizer: The Physical Society of Japan 2006 autumn meeting
  • Place of Presentation: Chiba, Japan
  • Year and Date: 20060900
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Raman spectroscopic analyses of fullerene nanotubes and nanowhiskers (2006)
  • Author(s): Miyazawa K, Mashino T, Nakamura S, Tachibana M, Nakamura K, Suga T.
  • Organizer: Nanotube 06: Seventh International Conference on the Science and Application of Nanotubes
  • Place of Presentation: Nagano,Japan
  • Year and Date: 20060600
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Raman spectroscopic analyses of fullerene nanotubes and nanowhiskers (2006)
  • Author(s): Miyazawa, K., Mashino, T., Nakamura, S., Tachibana, M., Nakamura, K., Suga, T
  • Organizer: Nanotube 06 : Seventh International Conference on the Science and Application of Nanotubes
  • Place of Presentation: Nagano, Japan
  • Year and Date: 20060600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] フラーレンナノウィスカー・フラーレンナノチューブの常温合成と物性 (2006)
  • Author(s): 宮澤 薫一, 湊 淳一, 加藤 良栄, 安坂 幸師, 木塚 徳志, 増野 匡彦, 中村 成夫, 橘 勝, 須賀 唯知
  • Organizer: フィジカルセンサ研究会
  • Place of Presentation: 東京
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Human Immunodeficiency Virus-Reverse Transcriptase Inhibition and Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibition Activities of Fullerene Derivatives (2006)
  • Author(s): Mashino, T., Shimotohno, K., Ikegami, N., Takahashi, K., Nakamura, S., Mochizuki M
  • Organizer: 209th Meeting of The Electrochemical Society
  • Place of Presentation: Denver, USA
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Ambient-temperature preparation of fullerene-nanowhisker and -nanotube, and its physical properties (2006)
  • Author(s): Miyazawa, K., Minato, J., Kato, R., Anzaka, K., Kizuka, T., Mashino, T., Nakamura, S., Taxhibana, M., Suga, T
  • Organizer: Physical-sensor Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Antioxidant and prooxidant activity off fullerene derivative (2006)
  • Author(s): Satake, E., Takahashi, K., Nakamura, S., Mashino, T., Matsubayashi, K
  • Organizer: 28th Annual Meeting of the Society of Free Radical, Japan
  • Place of Presentation: Tsu, Japan
  • Year and Date: 20060500
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] フラーレンナノウィスカー・ナノチューブのラマン分析 (2006)
  • Author(s): 宮澤 薫一、増野 匡彦、中村 成夫、須賀 唯知
  • Organizer: 第61回物理学会春季大会
  • Place of Presentation: 松山
  • Year and Date: 20060300
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Effect and the mechanism of HIV reverse transcriptase inhibition by proline-type fullerene derivatives (2006)
  • Author(s): Ikegami, N., Takahashi, K., Nakamura, S., Shimotohno, K., Mochizuki, M., Mashino, T
  • Organizer: 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai, Japan
  • Year and Date: 20060300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Substituent effect on cytotoxicity of fullerene derivatives (2006)
  • Author(s): Hashimoto, N., Takahashi, K., Nakamura, S., Mashino, T
  • Organizer: 126th Annual Meeting of the Pharmaceutical Society of Japan
  • Place of Presentation: Sendai, Japan
  • Year and Date: 20060300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Raman spectroscopic analysis of fullerene-nano whisker and -nano tube (2006)
  • Author(s): Miyazawa, K., Mashino, T., Nakamura, S., Suga, T
  • Organizer: 61th Annual Meeting of the Physical Society of Japan
  • Place of Presentation: Matsuyama, Japan
  • Year and Date: 20060300
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] がん細胞増殖抑制作用を有するフラーレン誘導体による細胞内活性酸素生成 (2006)
  • Author(s): 西澤 千穂, 橋本 規行, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 第21回日本フリーラジカル学会関東支部会
  • Place of Presentation: 東京
  • Year and Date: 2006-12-02
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] フラーレン誘導体によるナノウィスカー合成とその物性 (2006)
  • Author(s): 増野 匡彦
  • Organizer: 物理学会2006秋季大会
  • Place of Presentation: 千葉
  • Year and Date: 2006-09-25
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] フラーレン誘導体の抗酸化作用とプロオキシダント効果の検討 (2006)
  • Author(s): 佐竹 恵理子, 高橋 恭子, 中村 成夫, 増野 匡彦, 松林 賢司
  • Organizer: 第28回日本フリーラジカル学会学術集会
  • Place of Presentation: 津
  • Year and Date: 2006-05-13
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Human Immunodeficiency Virus-Reverse Transcriptase Inhibition and Hepatitis C Virus RNA-Dependent RNA Polymerase Inhibition Activities of Fullerene Derivatives (2006)
  • Author(s): Mashino T, Shimotohno K, Ikeganu N, Takahashi K, Nakamura S. Morhizuki M.
  • Organizer: 209th Meeting of The Electrochemical Society
  • Place of Presentation: Denver,USA
  • Year and Date: 2006-05-11
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] C60プロリン誘導体によるHIV逆転写酵素阻害効果及びその阻害機構 (2006)
  • Author(s): 池上 典子, 高橋 恭子, 中村 成夫, 下遠野 久美子, 望月 正隆, 増野 匡彦
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 2006-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] フラーレン誘導体置換基の種類による細胞毒性発現 (2006)
  • Author(s): 橋本 規行, 高橋 恭子, 中村 成夫, 増野 匡彦
  • Organizer: 日本薬学会第126年会
  • Place of Presentation: 仙台
  • Year and Date: 2006-03-28
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inhibition of HIV-reverse transcriptase by mono- or bis-substituted fullerene derivatives (2005)
  • Author(s): Ikegami, N., Shimotohno, K., Nishikawa, D., Takahashi, K., Nakamura, S., Mochizuki M., Mashino, T
  • Organizer: International Chemical Congress of Pacific Basin Societies2005
  • Place of Presentation: Honolulu, USA
  • Year and Date: 20051200
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Fullerene derivative as Nano material and the Nano whisker (2005)
  • Author(s): Mashino, T., Nakamura, S., Miyazawa, K
  • Organizer: FNW Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20051200
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Structural characterization of room-temperature synthesized fullerene nanowhiskers (2005)
  • Author(s): Miyazawa K, Minato J, Mashino T, Nakamura S, Fujino M, Suga T.
  • Organizer: 2nd Poland-Japan Workshop on Material Science
  • Place of Presentation: Warsaw,Poland
  • Year and Date: 20051000
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structural characterization of room-temperature synthesized fullerene nanowhiskers (2005)
  • Author(s): Miyazawa, K., Minato, J., Mashino, T., Nakamura, S., Fujino, M., Suga, T
  • Organizer: 2nd Poland-Japan Workshop on Material Science
  • Place of Presentation: Warsaw, Poland
  • Year and Date: 20051000
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] C60誘導体を添加したC60ナノウィスカーの構造 (2005)
  • Author(s): 宮澤 薫一, 増野 匡彦, 中村 成夫, 須賀 唯知
  • Organizer: 2006年春期金属学会講演大会
  • Place of Presentation: 広島
  • Year and Date: 20050900
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Structure of C60 Nano whisker containing C60 derivative (2005)
  • Author(s): Miyazawa, K., Mashino, T., Nakamura, S., Suga, T
  • Organizer: 2006 Spring Meeting of The Japan Institute of Metals
  • Place of Presentation: Hiroshima, Japan
  • Year and Date: 20050900
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Characterization of the Liquid-Phase Synthesized Fuilrene Nanotube and Nanowhisker (2005)
  • Author(s): Miyazawa K, J.Minato J, T.Mashino T, Yoshli T. Kizuka T, Kato R, Tachibana M, Suga T.
  • Organizer: The 13th JSME Materials and Processing Conference
  • Place of Presentation: Seattle,USA
  • Year and Date: 20050600
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Characterization of the Liquid-Phase Synthesized Fullrene Nanotube and Nanowhisker (2005)
  • Author(s): Miyazawa, K., J., Minato J, T., Mashino, T., Yoshii, T., Kizuka, T., Kato, R., Tachibana, M., Suga, T
  • Organizer: The 13th JSME Materials and Processing Conference
  • Place of Presentation: Seattle, USA
  • Year and Date: 20050600
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] Preparation and characterization of short fullerene nanowhiskers (2005)
  • Author(s): Miyazawa K, Minato J, Mashino T, Suga T.
  • Organizer: The 10th International Conference on New Diamond Science and Technology
  • Place of Presentation: Tukuba
  • Year and Date: 20050500
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Application of fullerenes to medicals (2005)
  • Author(s): Mashino, T., Nakamura, S., Miyazawa, K
  • Organizer: Nano-access Symposium
  • Place of Presentation: Tokyo, Japan
  • Year and Date: 20050400
  • Description: 「研究成果報告書概要(欧文)」より
• [Presentation] ナノマテリアルとしてのフラーレン誘導体とそのナノウィスカー (2005)
  • Author(s): 増野 匡彦、中村 成夫、宮澤 薫一
  • Organizer: FNW研究会
  • Place of Presentation: 東京
  • Year and Date: 2005-12-19
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] Inhibition of HIV-reverse transcriptase by mono- or bis-substituted fullerene derivatives (2005)
  • Author(s): Ikegami N, Shimotohno K, Nishikawa D, Takahashi K, Nakamura S, Mochizuki M, Mashino T.
  • Organizer: International Chemical Congress of Pacific Basin Societies2005
  • Place of Presentation: Honolulu,USA
  • Year and Date: 2005-12-18
  • Description: 「研究成果報告書概要(和文)」より
• [Presentation] フラーレン類の医療への応用 (2005)
  • Author(s): 増野 匡彦、中村 成夫、宮澤 薫一
  • Organizer: ナノテクアセス研究会
  • Place of Presentation: 東京
  • Year and Date: 2005-04-13
  • Description: 「研究成果報告書概要(和文)」より
• [Book] ナノカーボンハンドブック(遠藤 守信, 飯島澄男監修), フラーレンの抗菌薬、抗ウイルス薬等医薬への応用 (2007)
  • Author(s): 中村 成夫, 増野 匡彦, 他180名
  • Total Pages: 668-673
  • Publisher: エヌ・アイー・エス
  • Description: 「研究成果報告書概要(和文)」より
• [Book] 各ナノ粒子の毒性評価・安全性試験の動向フラーレン (2007)
  • Author(s): 増野 匡彦, 中村 成夫
  • Total Pages: 383-396
  • Publisher: 技術情報協会
  • Description: 「研究成果報告書概要(和文)」より