2007 Fiscal Year Final Research Report Summary
In-Vivo microscopic observation of rabhit intrahcpatic haemodynamic change fir analysis of transcatheter arterial embolization therapy
| Project/Area Number |
17591256
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Radiation science
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| Research Institution | Kanazawa University |
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Principal Investigator |
KOBAYASHI Satoshi Kanazawa University, Graduste School of Medicine, Assistant Professor (30313638)
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| Co-Investigator(Kenkyū-buntansha) |
MATSUI Osamu Kanazawa University, Graduate School of Medicine, Professor (10019961)
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| Project Period (FY) |
2005 – 2007
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| Keywords | Hepatocellular carcinoma / In-Vivo microscope / Transcatheter embolization |
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| Research Abstract |
To decide the hepatic sinusoidal flow velocity, at fires, the hematocyte moving images were recorded using video-capturing method under in-vivo microscopy of rabbit liver. And then the captured image analysis was done on computer software and finally estimated sinusoidal blood flow velocity was calculated.
At first, average flow velocity of the sinusoids was about 30 pixel/flame. However, the flow velocity decreases within ten minutes according to the changes of rabbit body conditions such as body temperature and heart rates, respiratory rates. According to these results, strict control of rabbit body condition was necessary for further analysis of sinusoidal blood flow.
This research aimed at the basic research for transcatheter arterial embolization of hepatic tumor using in-vivo microscopic method in small animal such as rabbit. And our current conclusion is to use bigger animal is important to get better data on in-vivo microscopic observation of vital liver blood flow without variability caused by animal condition change.
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