2006 Fiscal Year Final Research Report Summary
Analysis of bioactive function of angiotensin II in prostate cancer
| Project/Area Number |
17591689
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| Research Category |
Grant-in-Aid for Scientific Research (C)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Urology
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| Research Institution | Yokohama City University Hospital |
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Principal Investigator |
UEMURA Hiroji Yokohama City University, Hospital, Dept. of Urology, Associate Professor, 附属病院, 準教授 (50244439)
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| Co-Investigator(Kenkyū-buntansha) |
YOSHINOBU Kubota Yokohama City University, Sch. of Med, Dept. of Urology, Professor, 医学研究科, 教授 (10106312)
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| Project Period (FY) |
2005 – 2006
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| Keywords | Angiotensin II / Prostate cancer |
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| Research Abstract |
Angiotensin II (Ang-II) plays a key role as a vasoconstrictor in controlling blood pressure and electrolyte/fluid homeostasis, and it has recently been shown that this peptide is a cytokine, especially acting as a growth factor in cardiovascular and stromal cells. In addition, the physiological function of Ang-II seems to be similar in prostate cancer and stromal cells. It is widely assumed that Ang-II facilitates the growth of both cells, and its receptor blockers (ARBs) have the potential to inhibit the growth of various cancer cells and tumors through the AT1 receptor. The mechanism of cell growth inhibition by ARBs has been considered to be suppression of the signal transduction systems activated by growth factors or cytokines in prostate cancer cells, and suppression of angiogenesis. This research may lead to develop the chemo-prevention or drug discovery of prostate cancer.
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Research Products
(22 results)
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[Journal Article] Stable suppression of tumorigenicity by Pin1-targetted small interfering RNA in prostate cancer.2005
Author(s)
Ryo, A., Uemura, H., Ishiguro, H., Perrem, K., Kubota, Y, Aoki, I.
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Journal Title
Clinc.Cancr Res. 11
Pages: 7523-7531
Description
「研究成果報告書概要(欧文)」より
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[Journal Article] Treatment of androgen-independent, hormone-refractory prostate cancer with docetaxel in Japanese patients.2005
Author(s)
Y Miyoshi, H Uemura, M Nakamura, H Hasumi, S Sugiura, K Makiyama, N Nakaigawa, T Kishida, T Ogawa, M Yao, Y Kubota.
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Journal Title
Int J Clin Oncol. 10
Pages: 182-6
Description
「研究成果報告書概要(欧文)」より
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