がん臨床研究における多変量生存時間データの解析

2007 Fiscal Year Annual Research Report

• Project/Area Number: 17700275
• Research Institution: The University of Tokyo
• Principal Investigator: 山口 拓洋 The University of Tokyo, 医学部・附属病院, 容員准教授 (50313101)
• Keywords: 生物統計学 / 生存時間解析 / がん

Research Abstract

平成17,18年度に引き続き、がん臨床試験における多変量生存時間データの解析方法について、実データへの適用を考慮いつつ検討した。
・クラスターデータの解析
昨年度の胃がんの手術療法に関する多施設臨床試験データの解析に加えて、同じく胃がんの化学療法に関する多施設臨床試験データを用いて、施設間差の検討を行った。Frailtyモデルのパラメータ推定にはWinBUGSを用いた。ペナルティー付き尤度に基づく方法などと比して、ベイズ流のアプローチを用いることで安定した結果が得られ、推定の性能も良好であった。
・多段階遷移データ及び競合危険データの解析
血液がんにおける移植療法のデータを中心に検討した。多段階遷移データに関して、GVL効果を検討するために提案されている複数の統計モデルについて比較を行った。通常用いられている、GVHDの発症を時間依存性変数として考慮したCox回帰モデルの適用には限界があると考えられたが、一方で、他の因果モデルの適用についても既存のデータを生状況が直感的に理解できるようなグラフ表示方法について検討した。また、Cumulative Incidence及び対応する回帰手法である競合危険回帰について、どのような状況において用いることが適当であるか実データに基づき検討した。競合危険回帰については、利用可能な統計パッケージについて調査した。

Research Products

• [Journal Article] Regional differences exist in allogeneic stem cell transplantation rates for acute leukemia. (2008)
  • Author(s): Miura Y, Yamaguchi T, Azuma T, Hamaki T, Kodama Y, Kusumi E, Matsumura T, Nakamura T, Kami M, Komatsu T.
  • Journal Title: International Journal of Hematology 87 Pages: 236-238
  • Peer Reviewed
• [Journal Article] Comparative single-institute analysis of cord blood transplantation from unrelated donors with bone marrow or peripheral blood stem cell trans plantation from related donors in adult patients with hematological malignancies after myeloablative conditioning regimen. (2007)
  • Author(s): Takahashi S, Ooi J, Tomonari A, Konuma T, Tsukada N, Oiwa-Monna M, Fukuno K, Uchiyama M, Takasugi K, Iseki T, Tojo A, Yamaguchi T, Asano S.
  • Journal Title: Blood 109 Pages: 1332-1330
  • Peer Reviewed
• [Journal Article] Tacrolimus as prophylaxis for acute graft-versus-host disease in reduced intensity cord blood transplantation for adult patients with advanced hematologic diseases. (2007)
  • Author(s): Miyakoshi S, Kami M, Tanimoto T, Yamaguchi T, Narimatsu H, Kusumi E, Matsumura T, Takagi S, Kato D, Kishi Y, Murashige N, Yuji K, Uchida N, Masuoka K, Wake A, Taniguchi S.
  • Journal Title: Transplantation 84 Pages: 316-322
  • Peer Reviewed
• [Journal Article] Impact of cytomegalovirus serostatus on outcome of unrelated cord blood transplantation for adults: a single-institute experience in Japan. (2007)
  • Author(s): Tomonari A, Takahashi S, Ooi J, Tsukada N, Konuma T, Kato S, Kasahara S, Iseki T, Yamaguchi T, Tojo A, Asano S.
  • Journal Title: European Journal of Haematology 80 Pages: 251-257
  • Peer Reviewed
• [Journal Article] Estimation of the marginal survival time in the presence of dependent competing risks using inverse probability of censoring weighted (IPCW) methods. (.)
  • Author(s): Matsuyama Y, Yamaguchi T
  • Journal Title: Pharmaceutical Statistics (In press)(掲載確定)
• [Presentation] Equivalent disease-free survival results after CBT ahd BMT from unrelated donor using TBI containing myeloablative regimen and calsinulin inhibitors plus MTX methods in patients with MDS in Japan: multivariate analysis by competing risk regression models. (2008)
  • Author(s): Takahashi S, Yamaguchi T, Monna-Ooiwa M, Taniguchi S, Akiyama H, Morii T, Nagari Y, Takaue Y, Okamoto S, Miyamura K, Sao H, Nagamura T, Kato S, Kawase T, Morishima Y, Asano Son behalf of the Japan Marrow Donor Program and the Japan Cord Blood Bank.
  • Organizer: 34th Annual Meeting of the European Group for Blood and Marrow Transplantation
  • Place of Presentation: Florence
  • Year and Date: 20080300
• [Presentation] The Comparative Analysis of Bone Marrow Transplantation and Cord Blood Transplantation from Unrelated Donors in Patients with Myelodysplastic Syndrome in Japan. (2007)
  • Author(s): Takahashi S, Yamaguchi T, Ooi J, Tomonari A, Tsukada N, Konuma T, Nagamura T, Kato S, Kawase T, Morishima Y, Asano S.
  • Organizer: ASH Annual Meeting
  • Place of Presentation: Atlanta
  • Year and Date: 20071100
• [Presentation] Unrelated Cord Blood Transplantation Using Myeloablative Regimen for Acute Leukemia Patients Aged between 50 and 55 Years: Single Institutional Retrospective Comparison with Patients Less Than 50 Years of Age. (2007)
  • Author(s): Konuma T, Takahashi S, Ooi J, Tomonari A, Tsukada N, Kato A, Oiwa-Monna M, Uchimaru K, Tojo A, Yamaguchi T, Asano S.
  • Organizer: ASH Annual Meeting
  • Place of Presentation: Atlanta
  • Year and Date: 20071100
• [Presentation] Unrelated Cord Blood Transplanation for Malignant Lymphoma: A Retro spective Study from the Japan Cord Blood Bank Network (JCBNW). (2007)
  • Author(s): Takita M, Yuji K, Yamaguchi T, Matsumura T, Kami M, Sakamaki H, Kouzai Y, Okada M, Osugi Y, Kobayashi R, Inoue M, Takahashi S, Murata M, Kai S, Kato K, Nagamura T, Taniguchi S, Kato S.
  • Organizer: ASH Annual Meeting
  • Place of Presentation: Atlanta
  • Year and Date: 20071100
• [Presentation] Acute Graft-Versus-Host Disease Following Umbilical Cord Blood Transplantation: Retrospective Survey Involving 2015 Japanese Patients. (2007)
  • Author(s): Miyakoshi S, Yamaguchi T, Kami M, Matsumura T, Yuji K, Narimatsu H, Kusumi E, Sakamaki H, Kouzai H, Okada M, Osugi Y, Kobayashi R, Inoue M, Takahashi S, Murata M, Kai S, Kato K, Nagamura T, Taniguchi S, Kato S.
  • Organizer: ASH Annual Meeting
  • Place of Presentation: Atlanta
  • Year and Date: 20071100
• [Presentation] Quantitative evaluation of heterogeneities in treatment effects and baseline risks among hospitals: from a phase III surgicaltrial of gastric cancer. (2007)
  • Author(s): Kurokawa Y, Yamaguchi T, Yoshimura K, Yamamoto S, Nakamura N, Sasako M, Fukuda H.
  • Organizer: 43rd ASCO 2007 Annual Meeting
  • Place of Presentation: Chicago
  • Year and Date: 20070600