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2009 Fiscal Year Final Research Report

Unraveling molecular mechanisms to recreate 3D organ architecture

Research Project

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Project/Area Number 17GS0318
Research Category

Grant-in-Aid for Creative Scientific Research

Allocation TypeSingle-year Grants
Research InstitutionKyoto University

Principal Investigator

AGATA Kiyokazu  Kyoto University, 大学院・理学研究科, 教授 (70167831)

Project Period (FY) 2005 – 2009
Keywords幹細胞 / 位置情報 / 器官形成
Research Abstract

We investigated the mechanisms underlying organ regeneration from pluripotent stem cells in planarians. We applied these strategies to organ formation from mouse ES cells in vitro.

  • Research Products

    (30 results)

All 2010 2009 2008 2007 2006 2005

All Journal Article (23 results) (of which Peer Reviewed: 22 results) Presentation (4 results) Book (3 results)

  • [Journal Article] Different requirements for post-transcriptional regulators and translational initiation factors during planarian regeneration and stem cell maintenance.2010

    • Author(s)
      L. Rouhana, N. Shibata, K. Agata
    • Journal Title

      Dev. Biol. 341

      Pages: 429-443

    • Peer Reviewed
  • [Journal Article] Analysis of motor function modulated by cholonergic neurins in planarian Dugesia japonica2010

    • Author(s)
      K. Nishimura, Y. Kitamura, T. Taniguchi, K. Agata
    • Journal Title

      Neuroscience 168

      Pages: 18-30

    • Peer Reviewed
  • [Journal Article] Single-cell gene profiling of planarian stem cells using fluorescent activated cell sorting and its "index sorting" function for stem cell research.2010

    • Author(s)
      T. Hayashi, N. Shibata, R. Okumura, T. Kudome, O. Nishimura, H. Taru, K. Agata
    • Journal Title

      Dev. Growth Differ. 52

      Pages: 131-144

    • Peer Reviewed
  • [Journal Article] Cellular and molecular dissection of pluripotent adult somatic stem cells in planarians.2010

    • Author(s)
      N. Shibata, L. Rouhana, K. Agata
    • Journal Title

      Dev. Growth Differ. 52

      Pages: 27-41

    • Peer Reviewed
  • [Journal Article] Planarian Hedgehog/Patched establishes anterior-posterior polarity by regulating Wnt signaling.2009

    • Author(s)
      S. Yazawa, Y. Umesono, T. Hayashi, H. Tarui, K. Agata
    • Journal Title

      Proc. Natl. Acad. Sci. USA 106

      Pages: 22329-22334

    • Peer Reviewed
  • [Journal Article] Planarians maintain a constant ratio of different cell types during changes in body size by using the stem cell system2009

    • Author(s)
      H. Takeda, K. Nishimura, K. Agata
    • Journal Title

      Zool. Sci. 26

      Pages: 805-813

    • Peer Reviewed
  • [Journal Article] Identification of a novel planarian G-protein-coupled receptor that responds to serotonin in Xenopus laevis oocytes K. Nishimura2009

    • Author(s)
      K. Unemura, J. Tsushima, Y. Yamauchi, J. Otomo, T. Taniguchi, S. Kaneko, K. Agata, Y. Kitamura
    • Journal Title

      Biol. Pharm. Bull. 32

      Pages: 1672-1677

    • Peer Reviewed
  • [Journal Article] Evolution and regeneration of the planarian central nervous system2009

    • Author(s)
      Y. Umesono, K. Agata
    • Journal Title

      Growth Differ. 51

      Pages: 185-195

    • Peer Reviewed
  • [Journal Article] Charactization of tyramine β-hydroxylase in planarian Dugesia japonica, Cloning and expression.2008

    • Author(s)
      K. Nishimura, Y. Kitamura, T. Inoue, Y. Umesono, K. Yoshimoto, T. Taniguchi, K. Agata
    • Journal Title

      Neurochemi. Inter. 53

      Pages: 184-192

    • Peer Reviewed
  • [Journal Article] Identification of glutamic acid decarboxylase gene and distribution of GABAergic nervous system in the planarian Dugesia laponica.2008

    • Author(s)
      K. Nishimura, Y. Kitamura, Y. Umesono, K. Takeuchi. K. Takata, T. Taniguchi, K. Agata
    • Journal Title

      Neuroscience 153

      Pages: 1103-1114

    • Peer Reviewed
  • [Journal Article] Expression and functional analysis of musashi-like genes in planarian CNS regeneration.2008

    • Author(s)
      S. Higuchi, T. Hayashi, H. Tarui, O. Nishimura, K. Nishimura, N. Shibata, H. Sakamoto, K. Agata
    • Journal Title

      Mech. Dev. 25

      Pages: 631-645

    • Peer Reviewed
  • [Journal Article] Brain regeneration from pluripotent stem cells in planarian.2008

    • Author(s)
      K. Agata, Y. Umesono
    • Journal Title

      Phil. Trans. R. Soc. Lond. B. Biol. Sci. 363

      Pages: 2071-2078

    • Peer Reviewed
  • [Journal Article] Identification of glutamic acid decarboxylase gene and distribution of GABAergic nervous system in the planarian Dugesia japonica.2008

    • Author(s)
      K. Nishimura, Y. Kitamura, Y. Umesono, K. Takeuchi, K. Takata, T. Taniguchi, K. Agata
    • Journal Title

      Neurosci. 153

      Pages: 1103-1114

    • Peer Reviewed
  • [Journal Article] Characterization and categorization of FACS-sorted planarian stem cells by ultrastructural analysis.2007

    • Author(s)
      S. Higuchi, T. Hayashi, I. Hori, N. Shibata, H. Sakamot, K. Agata
    • Journal Title

      Dev. Growth Differ. 49

      Pages: 571-581

    • Peer Reviewed
  • [Journal Article] Wnt signaling is required for antero-posterior patterning of the planarian brain.2007

    • Author(s)
      C. Kobayashi, K. Ogawa, K. Agata
    • Journal Title

      Dev. Biol. 306

      Pages: 714-724

    • Peer Reviewed
  • [Journal Article] Clathrin-mediated endocytic signal is required for the regeneration as well as homeostasis of planarian CNS.2007

    • Author(s)
      T. Inoue, T. Hayashi, K. Takechi, K. Agata
    • Journal Title

      Development 134

      Pages: 1679-1689

    • Peer Reviewed
  • [Journal Article] Reconstruction of dopaminergic neural network and locomotion function in planarian regenerates.2007

    • Author(s)
      K. Nishimura, Y. Kitamura, T. Inoue, Y. Umesono, S. Sano, K. Yoshimoto, M. Inden, K. Takata, T. Taniguchi, S. Shimohama, K. Agata
    • Journal Title

      Dev. Neurobiol. 67

      Pages: 1059-1078

    • Peer Reviewed
  • [Journal Article] Regeneration-dependent conditional gene knockdown (Readyknock) in planarian: Demonstration of requirement for Djsnap-25 expression in the brain for negative phototactic behavior.2007

    • Author(s)
      T. Takano, J. Pulvers, T. Inoue, H. Tarui, H. Sakamoto, K. Agata, Y. Umesono
    • Journal Title

      Dev. Growth Differ. 49

      Pages: 383-394

    • Peer Reviewed
  • [Journal Article] Unifying principles of regeneration I: epimorphosis versus morphallaxis.2007

    • Author(s)
      K. Agata, Y. Saito, E. Nakajima
    • Journal Title

      Dev. Growth Differ. 49

      Pages: 73-78

    • Peer Reviewed
  • [Journal Article] Two different evolutionary origins of stem cell systems and their molecular basis2006

    • Author(s)
      K. Agata, E. Nakajima, N. Funayama, N. Shibata, Y. Saito, Y. Umesno
    • Journal Title

      Semin. Cell Dev. Biol. 17

      Pages: 503-509

    • Peer Reviewed
  • [Journal Article] Structure and function of primitive immunoglobulin superfamily neural cell adhesion molecules: a lesson from studies on planarian2006

    • Author(s)
      E. Fusaoka, T. Inoue, K. Mineta, K. Agata, K. Takeuchi
    • Journal Title

      Genes to Cells 11

      Pages: 541-555

    • Peer Reviewed
  • [Journal Article] Isolation of planarian X-ray-sensitive stem cells by fluorescence-activated cell sorting2006

    • Author(s)
      T. Hayashi, M. Asami, S. Higuchi, N. Shibata, K. Agata
    • Journal Title

      Dev. Growth Differ. 48

      Pages: 371-379

  • [Journal Article] Neural projections in planarian brain revealed by fluorescent dye tracing.2005

    • Author(s)
      K. Okamoto, K. Takeuchi, K. Agata
    • Journal Title

      Zool. Sci. 22

      Pages: 535-546

    • Peer Reviewed
  • [Presentation] Regeneration in planarian2009

    • Author(s)
      K. Agata
    • Organizer
      Frontiers in Stem Cells and Regeneration Advanced Training Course
    • Place of Presentation
      Woods Hole, USA
    • Year and Date
      2009-10-07
  • [Presentation] Brain regeneration from pluripotent stem cells in planarian German2009

    • Author(s)
      K. Agata
    • Organizer
      Dev. Biol. Meeting
    • Place of Presentation
      Hannover Germany
    • Year and Date
      2009-03-28
  • [Presentation] Maintenance and regulation of planarian pluripotent stem cells2008

    • Author(s)
      K. Agata
    • Organizer
      23th Naito Conference
    • Place of Presentation
      Shonan Village Centaer, Kanagawa Japan
    • Year and Date
      2008-11-12
  • [Presentation] Brain regeneration from pluripotent stem cells in planarian2007

    • Author(s)
      K. Agata
    • Organizer
      Biology Seminar
    • Place of Presentation
      UC Berkeley USA
    • Year and Date
      2007-10-31
  • [Book] Planaria: A Model for Drug Action and Abuse (Brain and neural networks)2008

    • Author(s)
      K. Nishimura, H. Yamamoto, Y. Kitamura, K. Agata
    • Total Pages
      12
    • Publisher
      LANDES BIOSCIENCE
  • [Book] Stem Cells: From Hydra To Man (Stem cells in planarian.)2008

    • Author(s)
      K. Agata
    • Total Pages
      59-74
    • Publisher
      Springer
  • [Book] Planarian nervous system2008

    • Author(s)
      H. Takeda, K. Nishimura, K. Agata
    • Total Pages
      5558
    • Publisher
      Scholarpedia

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Published: 2011-06-18   Modified: 2016-04-21  

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