Functional analysis of novel membrane complexes involved in collagen secretion and ERES formation

2020 Fiscal Year Final Research Report

• Project/Area Number: 17H03651
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Functional biochemistry
• Research Institution: Akita University
• Principal Investigator: Saito Kota 秋田大学, 医学系研究科, 教授 (60549632)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 分泌 / ER exit site / Sec16 / TANGO1

Outline of Final Research Achievements

How ER exit sites disassemble during mitosis was not well understood. We revealed that TANGO1, a cargo receptor originally identified for collagens, acts as a core for ER exit site disassembly. We revealed that TANGO1 is phosphorylated by Casein Kinase 1 and dephosphorylated by Protein Phosphatase 1.

Free Research Field

細胞生物学

Academic Significance and Societal Importance of the Research Achievements

我々は、細胞分裂期においてもERESが崩壊しない状態を作り出すことに成功した。これによって細胞分裂を停止することができれば、新たな抗がん剤の標的となりうる。