Development of uterus transplantation models in non-human primates

2019 Fiscal Year Final Research Report

• Project/Area Number: 17H05099
• Research Category: Grant-in-Aid for Young Scientists (A)
• Allocation Type: Single-year Grants
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: Kisu Iori 慶應義塾大学, 医学部(信濃町), 特任助教 (30445267)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 子宮移植 / 子宮性不妊症 / カニクイザル

Outline of Final Research Achievements

Cynomolgus macaques with mismatched and haploidentical MHC and compatible ABO blood type were selected, in which allogenic uterus transplantation were performed. We succeeded in first delivery after recovering from graft rejection and established development of uterus transplantation model in non-human primates.

Free Research Field

生殖医学

Academic Significance and Societal Importance of the Research Achievements

霊長類動物での安定した子宮同種移植モデルの作製は前例がなく、その作製の成功により今後の子宮移植の未解決な医学的課題の解明につながる。特にドナーレシピエント間でのHLAマッチングの必要性と免疫応答は臨床応用の最重要課題であり、患者の選択条件などに影響を与えることから、臓器移植領域での学術的意義は大きい。また新たな生殖医療の概念を産婦人科学に生み出すことが期待される。