2018 Fiscal Year Final Research Report
Development of novel pain therapeutics by microglia control
Project/Area Number |
17H06757
|
Research Category |
Grant-in-Aid for Research Activity Start-up
|
Allocation Type | Single-year Grants |
Research Field |
Surgical dentistry
|
Research Institution | Nagoya University |
Principal Investigator |
Kano Fumiya 名古屋大学, 医学部附属病院, 医員 (40801626)
|
Project Period (FY) |
2017-08-25 – 2019-03-31
|
Keywords | 神経障害性疼痛 / ミクログリア / エクソソーム / MCP-1 / Siglec / マクロファージ |
Outline of Final Research Achievements |
"Pain" is an important sense that informs the body of the invasion and damage, but there is "neuropathic pain" that persists even if the damage is repaired. It is known that the inflammation is degeneration of microglia. By applying anti-inflammatory M2 microglia-inducing factor to neuropathic model mice, the applicant transforms the tissue destructive inflammatory response into anti-inflammatory / tissue regeneration type Was found to promote pain control. In addition, the induced endoplasmic reticulum (exosome) released by M2 microglia was taken into the surrounding Schwann cells to control pain by controlling the inflammatory state and suppressing cell death.
|
Free Research Field |
再生医療
|
Academic Significance and Societal Importance of the Research Achievements |
疼痛の慢性化するメカニズムとして、神経細胞だけでなく、損傷した末梢神経に浸潤・集積するマクロファージと脊髄後角で活性化するミクログリアが重要な役割を担うことを示す基礎的論文が数多く蓄積されている。本研究はミクログリアやマクロファージの役割を深めることで、慢性疼痛のメカニズムの解明と治療薬の開発につながる重要な研究と考える。
|