Search for the antibacterial technology of medical devices using mass-produced graphene oxide as a carrier

2018 Fiscal Year Final Research Report

• Project/Area Number: 17H06881
• Research Category: Grant-in-Aid for Research Activity Start-up
• Allocation Type: Single-year Grants
• Research Field: Medical and hospital managemen
• Research Institution: Okayama University
• Principal Investigator: OKUBO Keisuke 岡山大学, 歯学部, 客員研究員 (00802349)
• Project Period (FY): 2017-08-25 – 2019-03-31
• Keywords: 社会医学 / 医療機器 / 院内感染 / 酸化グラフェン / ナノ材料

Outline of Final Research Achievements

The purpose of this research is to focus on the features of Graphene Oxide (GO) and to develop new materials that enable medical devices which have not been able to impart antimicrobial activity to maintain antimicrobial components.
CPC-GO was prepared by reacting GO with cetylpyridinium chloride (CPC), which has already been used as an antibacterial agent. As a result, CPC-GO exhibited higher retention on the test sample (silicon) as compared to CPC alone, and showed sufficient antimicrobial effect. In addition, it was confirmed that CPC was sufficiently introduced into GO, and the appropriate reaction amount in preparation of CPC-GO was elucidated (CPC:GO=1:1). And it was presumed that the chemical bonding pattern of CPC-GO was ionic bonding.

Free Research Field

歯周病学，歯科保存学，理工系歯学，病院・医療管理学

Academic Significance and Societal Importance of the Research Achievements

本研究によって，酸化グラフェン（GO）に期待される多彩な応用方法の１つに，抗菌剤のキャリアとしてGOを実用化しうることの現実性をより具体化することができた。
それは即ち，GOを応用することで，物質表面に抗菌成分を維持させる新しい発想の抗菌加工剤を開発することができ，既存の抗菌剤と比較して高い持続性や抗菌成分の低濃度化が期待できる。そして，今後医療を超えた様々な分野で応用可能な技術の礎となりうることこそが，本研究の意義である。