Analysis of adverse effects of acetylcholinergic pesticides focused on the induction of host defense reaction and immune disruption

2019 Fiscal Year Final Research Report

• Project/Area Number: 17K00547
• Research Category: Grant-in-Aid for Scientific Research (C)
• Allocation Type: Multi-year Fund
• Section: 一般
• Research Field: Risk sciences of radiation and chemicals
• Research Institution: Nagoya University
• Principal Investigator: Kawabe Tsutomu 名古屋大学, 医学系研究科(保健), 教授 (20378219)
• Co-Investigator(Kenkyū-buntansha): 松島 充代子 名古屋大学, 医学系研究科(保健), 講師 (10509665)
• Project Period (FY): 2017-04-01 – 2020-03-31
• Keywords: 農薬 / ネオニコチノイド系農薬 / マクロファージ / T細胞

Outline of Final Research Achievements

In this study, we investigated the effects of acetylcholinergic pestcides, particularly neonicotinoid pesticides, on the induction of host defense reaction and functions of macrophages and T cells. We showed that acetamiprid modulated the function of alveolar macrophages. Briefly, acetamiprid inhibited the levels of inflammatory cytokine mRNA expression and phagocytosis induced by imiquimod, a ligand of TLR7, in alveolar macrophages, while acetamiprid exhibited little effect on the induction of host defense reaction including HO-1 expression and autophagy. Moreover, acetamiprid did not affect T-cell activation. These results suggested the possibility that acetamiprid could influence the host defense reaction in the lung.

Free Research Field

免疫学

Academic Significance and Societal Importance of the Research Achievements

これまで神経系への影響が中心に解析されてきたAch作動系農薬が免疫系に与える影響について検討した。免疫応答は賦活化するとアレルギー性疾患や自己免疫疾患を発症させ、抑制されると免疫不全状態として感染症や免疫監視機構の減弱化による悪性腫瘍の発症に繋がる。ACh作動系農薬が及ぼす免疫応答の撹乱作用を明らかにできれば、新たな神経系と免疫系のネットワークを構築でき、また農薬をもとにした治療薬の開発が期待できる。