2020 Fiscal Year Final Research Report
Elucidation of elastin crosslinking structure and preparation of antigen/antibody of desmosines
Project/Area Number |
17K01953
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Research Category |
Grant-in-Aid for Scientific Research (C)
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Allocation Type | Multi-year Fund |
Section | 一般 |
Research Field |
Biomolecular chemistry
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Research Institution | Sophia University |
Principal Investigator |
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Project Period (FY) |
2017-04-01 – 2021-03-31
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Keywords | エラスチン / desmosine |
Outline of Final Research Achievements |
Elastin has crosslinking structure with desmosines. The first total synthesis of desmosines have been achieved in our group using cross-coupling reactions as well as Chichibabin pyridinium synthesis. In this study, based on the established synthetic strategy, cyclic peptides with desmosine have been accomplished. In addition, preparation of antigen of isodesmosine was carried out.
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Free Research Field |
天然物化学
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Academic Significance and Societal Importance of the Research Achievements |
本研究の遂行によって、エラスチンの分解をともなうCOPD(慢性閉塞性肺疾患)や動脈瘤、皮膚疾患などの疾患に対するバイオマーカー診断法の確立へつながる。
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