2022 Fiscal Year Final Research Report
| Project/Area Number |
17K07392
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (C)
|
| Allocation Type | Multi-year Fund |
|---|
| Section | 一般 |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Chuo University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2017-04-01 – 2023-03-31
|
| Keywords | 減数分裂 / 細胞周期 / 遺伝的組換え / チェックポイント / DNA複製 |
|---|
| Outline of Final Research Achievements |
Meiosis generates genetic diversity and is essential for gametogenesis, but there are many unclear points about its regulatory mechanism. In this study, we showed that Cds1 kinase phosphorylates the forkhead transcription factor Mei4 and that phosphorylation is required for checkpoints in the regulation of premeiotic DNA replication and initiation of recombination. Regarding the control mechanism of pre-meiotic DNA replication and first meiotic initiation, we showed that Cds1 phosphorylates Fkh2, a forkhead transcription factor, and that this phosphorylation is required for the checkpoint.
|
| Free Research Field |
生物学
|
| Academic Significance and Societal Importance of the Research Achievements |
減数分裂は遺伝的多様性を生み出し、配偶子形成に必須であるがその制御機構に関しては不明な点が多い。減数分裂において、細胞周期が順序正しく進行するために、チェックポイント機構が必要である。しかし、このチェックポイント機構は、ほとんどの生物で未解明であった。この研究により、その一部が明らかにされた。
|
